Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery

2016 ◽  
Vol 102 ◽  
pp. 33-54 ◽  
Author(s):  
Gemma O'Connor ◽  
Laura E. Gleeson ◽  
Aidan Fagan-Murphy ◽  
Sally-Ann Cryan ◽  
Mary P. O'Sullivan ◽  
...  

2013 ◽  
Vol 4 (2) ◽  
pp. 106
Author(s):  
Alaine Maria Da Costa ◽  
Gislane De Sousa Rodrigues ◽  
Tatiana Maria De Melo Guimarães Dos Santos

Resumo: Objetivou-se refletir e discutir sobre o papel potencial do enfermeiro no enfrentamento do problema da tuberculose junto ao Agente Comunitário de Saúde no Programa de Controle da Tuberculose. Trata-se de pesquisa descritiva, de abordagem quantitativa, com desenho de estudo transversal. A amostra constituiu-se de 121 Agentes Comunitários de Saúde (ACS) da Estratégia Saúde da Família (ESF) - zona urbana de Teresina. Evidenciou-se que 71,1% dos sujeitos admitiram procurar o enfermeiro da ESF em caso de dúvidas frente a casos suspeitos de tuberculose. Ao enfermeiro cabem intervenções pertinentes no controle da tuberculose tanto no âmbito político quanto operativo.Palavras-Chave: Enfermagem, Atenção Básica à Saúde, Tuberculose.The potential role of nurses in addressing the problem of tuberculosis with the Community Health Agent Program Control TuberculosisAbstract: The objective of this study was to reflect and discuss about the potential role of the nurses at the tuberculosis combat, helping the Community Health Agent at the Program of Tuberculosis Control. This is a descriptive study that uses a quantitative approach, with a cross-sectional study design. The group studied was formed of 121 Community Health Agents of The Family Health Strategy in the urban zone of Teresina. It was observed that 71.1% of the agents admitted to need help of a nurse when they have doubts related to suspected cases of tuberculosis. Relevant interventions in tuberculosis control are responsibility of the nurses at a political and an operational scope.Keywords: Nursing, Basic Attention Health, Tuberculosis.El papel potencial de las enfermeras para resolver el problema de la tuberculosis con el control de la Salud de la Comunidad del Agente de Program Tuberculosis.Resumen: Se objetivó con este estudio reflexionar y debatir sobre el papel potencial de los enfermeros en la lucha contra la tuberculosis, junto a los agentes comunitarios de salud en el Programa de Control de la Tuberculosis. Este es un estudio descriptivo que utiliza un abordaje cuantitativo, con un diseño de estudio transversal. El grupo estudiado poseía 121 ACS de la Estrategia Salud de la Familia - zona urbana de Teresina. Se observó que 71,1% de los agentes admiten buscar a un enfermero cuando existen dudas en relación a los casos sospechosos de tuberculosis. Al enfermero, caben las intervenciones pertinentes en el control de la tuberculosis tanto en el alcance político como operacionalPalabras Clave: Enfermería, Atención Básica a la Salud, Tuberculosis.



2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.



1996 ◽  
Vol 26 (9) ◽  
pp. 1005-1019 ◽  
Author(s):  
L. M. TERAN ◽  
D. E. DAVIES




Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.



Author(s):  
Edward M. Sellers ◽  
S. Victoria Otton ◽  
Rachel F. Tyndale






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