scholarly journals ASSESSING THE SPLEEN AS AN ORGAN AT RISK IN RADIOTHERAPY AND ITS RELATIONSHIP WITH RADIATION-INDUCED LYMPHOPENIA: A RETROSPECTIVE STUDY AND LITERATURE REVIEW

2021 ◽  
pp. 100761
Author(s):  
Michire Alexandru ◽  
Anghel Rodica ◽  
Georgescu Dragos-Eugen ◽  
Georgescu Mihai-Teodor
2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Jennifer Fuller ◽  
Matthew Naunheim ◽  
Matthew Dedmon ◽  
Stacey Gray ◽  
Derrick Lin

2006 ◽  
Vol 13 (3) ◽  
pp. 108-115 ◽  
Author(s):  
O. Ballivy ◽  
W. Parker ◽  
T. Vuong ◽  
G. Shenouda ◽  
H. Patrocinio

We assessed the effect of geometric uncertainties on target coverage and on dose to the organs at risk (OARS) during intensity-modulated radiotherapy (IMRT) for head-and-neck cancer, and we estimated the required margins for the planning target volume (PTV) and the planning organ-at-risk volume (PRV). For eight headand- neck cancer patients, we generated IMRT plans with localization uncertainty margins of 0 mm, 2.5 mm, and 5.0 mm. The beam intensities were then applied on repeat computed tomography (CT) scans obtained weekly during treatment, and dose distributions were recalculated. The dose–volume histogram analysis for the repeat CT scans showed that target coverage was adequate (V100 ≥ 95%) for only 12.5% of the gross tumour volumes, 54.3% of the upper-neck clinical target volumes (CTVS), and 27.4% of the lower-neck CTVS when no margins were added for PTV. The use of 2.5-mm and 5.0-mm margins significantly improved target coverage, but the mean dose to the contralateral parotid increased from 25.9 Gy to 29.2 Gy. Maximum dose to the spinal cord was above limit in 57.7%, 34.6%, and 15.4% of cases when 0-mm, 2.5-mm, and 5.0-mm margins (respectively) were used for PRV. Significant deviations from the prescribed dose can occur during IMRT treatment delivery for headand- neck cancer. The use of 2.5-mm to 5.0-mm margins for PTV and PRV greatly reduces the risk of underdosing targets and of overdosing the spinal cord.


BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017515 ◽  
Author(s):  
Rebecca Guest ◽  
Yvonne Tran ◽  
Bamini Gopinath ◽  
Ian D Cameron ◽  
Ashley Craig

ObjectiveTo determine whether psychological distress associated with musculoskeletal injuries sustained in a motor vehicle crash (MVC), regardless of time of onset, impacts compensation outcomes such as claim settlement times and costs. Second, to identify factors routinely collected by insurance companies that contribute to psychological distress during the compensation process.DesignStatewide retrospective study.Data sourceAnalysis of the New South Wales statewide (Australia) injury register for MVC survivors who lodged a compensation claim from 2011 to 2013.Participants6341 adults who sustained a musculoskeletal injury and who settled a claim for injury after an MVC. Participants included those diagnosed with psychological distress (n=607) versus those not (n=5734).Main outcome measuresTime to settlement and total costs of claims, as well as socio-demographic and injury characteristics that may contribute to elevated psychological distress, such as socio-economic disadvantage, and injury severity.ResultsPsychological distress in those with a musculoskeletal injury was associated with significantly longer settlement times (an additional 17 weeks) and considerably higher costs (an additional $A41 575.00 or 4.3 times more expensive). Multivariate logistic regression analysis identified risk factors for psychological distress including being female, social disadvantage, unemployment prior to the claim, not being at fault in the MVC, requiring ambulance transportation and rehabilitation as part of recovery.ConclusionsResults provide compelling evidence that psychological distress has an adverse impact on people with musculoskeletal injury as they progress through compensation. Findings suggest that additional resources should be directed toward claimants who are at risk (eg, the socially disadvantaged or those unemployed prior to the claim), the major aim being to reduce risk of psychological distress, such as post-traumatic stress disorder, and associated risk of increased settlement times and claim costs. Prospective studies are now required that investigate treatment strategies for those at risk of psychological distress associated with an MVC.


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