Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: The Strong Heart Study (SHS)

2006 ◽  
Vol 151 (2) ◽  
pp. 412-418 ◽  
Author(s):  
Jorge R. Kizer ◽  
Jonathan N. Bella ◽  
Vittorio Palmieri ◽  
Jennifer E. Liu ◽  
Lyle G. Best ◽  
...  
2002 ◽  
Vol 39 ◽  
pp. 440
Author(s):  
Jonathan N. Bella ◽  
Jennifer E. Liu ◽  
Mary J. Roman ◽  
David C. Robbins ◽  
Thomas K. Welty ◽  
...  

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Tomoyuki Kabutoya ◽  
Satoshi Hoshide ◽  
Kazuomi Kario

Background: The notched P-wave characteristics is associated with atrial remodeling. However, the relationship between notched P-wave characteristics and long-term cardiovascular events remains unclear. Hypothesis: We hypothesized that the notched P-wave would be associated with cardiovascular events. Methods: We enrolled 810 subjects from the J-HOP Study who had ≥1 of four cardiovascular risk factors. Twelve-lead electrocardiography was conducted, and the peak-to-peak distance in the M-shape was calculated automatically using a 12-lead ECG Analysis system (Fukuda Denshi, Tokyo). We compared two definitions: P waves were defined as "notched" if the peak-to-peak distance in the M-shape was ≥20 msec or ≥40 msec in lead II. The primary endpoints were fatal/nonfatal cardiovascular events: myocardial infarction, stroke, hospitalization for heart failure, and aortic dissection. We assessed the left atrial diameter and left ventricular mass index (LVMI) by echocardiography. Results: The mean follow-up period was 101±34 months, and 85 cardiovascular events occurred. When we defined a notched P wave as ≥20msec in the M shape (n=92), a notched P wave was a significant predictor of cardiovascular events after adjustment for age, gender, and comorbidity (hazard ratio 1.80, 95%CI: 1.06-3.05). When we defined a notched P wave as ≥40msec in the M shape (n=25), the hazard ratio of cardiovascular events in the notched P-wave group was significantly borderline after adjustment for covariates (hazard ratio 2.23, 95%CI: 0.90-5.56). The left atrial diameter and LVMI in the patients in the notched P-wave group (≥20 msec in the M shape) were significantly higher than those in the control group (left atrial dia. 38.8±5.9 vs. 36.8±5.0 mm, p=0.001; LVMI 103.9±27.7 vs. 96.3±25.7 g/m 2 , p=0.010). Conclusion: The automatically assessed notched P wave was associated with cardiovascular events, left atrial enlargement and left ventricular hypertrophy.


2017 ◽  
Vol 119 (11) ◽  
pp. 1757-1762 ◽  
Author(s):  
Jason F. Deen ◽  
Dorothy A. Rhoades ◽  
Carolyn Noonan ◽  
Lyle G. Best ◽  
Peter M. Okin ◽  
...  

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Stefano Caselli ◽  
Emanuele Canali ◽  
Maria Laura Foschi ◽  
Umberto Lombardi ◽  
Carlos Centurion ◽  
...  

Objective: we sought to identify, among all two-dimensional (2D), Doppler and three-dimensional (3D) echocardiography variables, the best predictor of adverse cardiovascular events in a 4 years follow-up study. Methods: A population of 151 consecutive sinus rhythm outpatients (mean age 57 ± 15 years) with cardiovascular risk factors, free from previous cardiovascular events or valvular heart disease, underwent 2D, Doppler and 3D echocardiography; data were indexed by body surface area. After a mean follow up of 54 ± 3 months, the study population was divided in two subgroups according to the subsequent development of cardiovascular events (death, myocardial infarction and stroke) or not. Results: combined endpoint was reached in 28 patients (18%). These patients showed significant differences for: e/e′ ratio (p<0.001), end systolic and end diastolic left ventricular (LV) diameters (p<0.05), 2D ejection fraction (p<0.01), 3D LV end diastolic (p<0.01) and end systolic volume (p<0.01), 3D LV mass (p<0.001) and ejection fraction (p<0.01), 3D left atrial maximum (p<0.001) and minimum volumes (p<0.001). By Cox Proportional Hazard analysis we were able to identify left atrial minimum volume as the best independent predictor of cumulative events (hazard ratio: 1.286, confidence interval 1.056 to 1.565; p=0.012). Kaplan-Meier analysis allowed to highlight statistically significant differences among tertiles of 3D left atrial minimum volume in terms of combined endpoint (p=0.002; Figure ). Conclusion: left atrial minimum volume obtained by 3D echocardiography, was in our selected population, the most powerful independent predictor of adverse cardiovascular events.


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