Serum albumin level is associated with the recurrence of acute ischemic stroke

Abstract Objectives We aimed to Detect if there is association between serum albumin level in acute ischemic stroke patients and its short term neurological and functional outcome in a tertiary care hospital in Cairo. Methods The study was carried out as descriptive (cross-sectional) study conducted on 50 cases first-ever acute ischemic stroke patients were enrolled between June 2018 to December 2018 with follow up after 30 days of discharge from hospital. Inclusion and exclusion criteria were strictly exercised. National Institute of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS) score was noted. Serum albumin (SA) was estimated from blood Clinical, functional, and radiological evaluation was done for the patients. Statistical SPSS 20.0 software and Microsoft excel were used for statistical analysis (P ≤ 0.05).Relationship between serum albumin and stroke outcome was determined. Results A total of 50 stroke cases were thus included in the study comprising 34 males and 16 females. The mean age of patients was 40-65 [59.26±6.25] years, we found the most prevalent risk factors in the present study results were hypertension 36 (72.0%). The mean serum level of albumin were (3.73±0.63) on day o of onset and (3.72±0.63) after 30 days of discharge from hospital. Bivariate analysis shows serum albumin was inversely associated with NIHS score and mRS on day o of onset and after 30 days of discharge from hospital which were NIHSS(r= -0.264, P = 0.044) (r= -0.645, P = <0.001) and mrs (r= -0.321, P = 0.031) (r= -0.587, P = <0.001) respectively. Conclusion Hypoalbuminemia had influence to degree of stroke severity, degree of disability and functional outcome. Serum albumin levels had a negatively correlation with NIHSS score and modified Rankin scale. Low serum albumin levels associated with poor prognosis in acute ischemic stroke patients.

Download Full-text

Validity and prognostic value of serum albumin level in emergency acute ischemic stroke egyptian patients

Medicine Science | International Medical Journal ◽

10.5455/medscience.2018.07.8844 ◽

2018 ◽

pp. 736

Author(s):

Adel Elbaih ◽

Islam Elshaboury ◽

Rasha Ahmed ◽

Monira Allah

Keyword(s):

Ischemic Stroke ◽

Serum Albumin ◽

Acute Ischemic Stroke ◽

Prognostic Value ◽

Serum Albumin Level ◽

Albumin Level ◽

Egyptian Patients

Download Full-text

Serum albumin level as prognostic indicator of acute ischemic stroke in tertiary care hospital admitted patients

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20202109 ◽

2020 ◽

Vol 7 (6) ◽

pp. 948

Author(s):

Prafulla Kumar Dash ◽

Smrutiranjan Behera ◽

Nirmal Chandra Sahoo ◽

Roma Rattan ◽

Saroj Kumar Tripathy

Keyword(s):

Ischemic Stroke ◽

Clinical Outcome ◽

Serum Albumin ◽

Acute Ischemic Stroke ◽

Functional Outcome ◽

Serum Albumin Level ◽

Albumin Level ◽

Osmotic Gradient ◽

Care Hospital

Background: Serum Albumin level is an important multifunctional protein in the blood for maintaining the normal permeability across vessel wall by osmotic gradient, in inhibiting platelet aggregation and in reducing blood viscosity. Serum albumin level as a novel parameter for predicting outcome and assessment of severity of coronary artery disease is established. Keeping in mind the scarcity of studies regarding albumin level in ischemic Cerebrovascular Accident (CVA), present study was undertaken to correlate serum albumin level with clinical outcome in acute ischemic stroke (AIS) patients.Methods: One hundred patients of diagnosed AIS were included in the study. Thorough clinical examination and risk factor profile assessment was done. Severity of stroke was assessed using National Institute of Health Stroke Scale (NIHSS) Score and then followed up to 1 week and 3 months post-admission with serum albumin level and assessment was done using modified Rankin Scale (mRS) score. Institutional ethics committee cleared the study.Results: In 100 patients with AIS, 58% were male and 42% were female. Mean age was 65±8.160. Motor weakness (85%) was the commonest presenting symptom. Around 75% of patients revealed infarction in middle cerebral artery (MCA) territory. Hypertension (HTN) (74%) was the most frequently associated comorbid condition. Patients with low serum albumin level at admission time were directly proportional to severity of stroke at presentation and poor clinical outcome. 1 week and 3 months follow up mean albumin level (g/dl) was 3.8±0.25 and 3.7±0.23 in patients with poor functional outcome respectively. Significant co-relation between mean serum albumin level and clinical outcome was observed.Conclusions: Serum albumin level is inversely correlated with severity of stroke at presentation and functional outcome in patients on follow up.

Download Full-text

Serum Albumin Level as a Predictor of Ischemic Stroke Outcome

Stroke ◽

10.1161/01.str.0000145487.89910.12 ◽

2004 ◽

Vol 35 (11) ◽

pp. 2435-2436 ◽

Cited By ~ 2

Author(s):

Raymond CS Seet ◽

Erle CH Lim ◽

Bernard PL Chan ◽

Benjamin KC Ong

Keyword(s):

Ischemic Stroke ◽

Serum Albumin ◽

Serum Albumin Level ◽

Albumin Level ◽

Stroke Outcome

Download Full-text

SERUM ALBUMIN LEVELS AND ITS CORRELATION WITH SHORT TERM OUTCOME IN ACUTE ISCHEMIC STROKE PATIENTS

10.36106/ijsr/6805828 ◽

2021 ◽

pp. 12-13

Author(s):

Avtar Singh Dhanju ◽

Thiyagu K ◽

Ajay Chhabra ◽

Pashaura Singh

Keyword(s):

Ischemic Stroke ◽

Serum Albumin ◽

Acute Ischemic Stroke ◽

Albumin Level ◽

Stroke Severity ◽

Stroke Patients ◽

Short Term ◽

Term Outcome ◽

Nihss Score ◽

The Relationship

Aim:The study was undertaken with the aim to establish the denite correlation between serum albumin levels and outcome of ischemic stroke. Methodology: The present observational study was conducted on 100 acute ischemic stroke patients meeting inclusion and exclusion criteria. All patients were investigated for hypoalbuminemia and their stroke severity was assessed by NIHSS score on day 1 and day 7. The relationship between admission albumin levels, NIHSS values and outcome of those patients was ascertained. Results: There was increased prevalence of hypoalbuminemia in AIS patients and there was signicant correlation between NIHSS score on day 1&7, mortality and hypoalbuminemia in AIS patients and there was signicant association between high NIHSS score and mortality in AIS patients. Conclusion: serum albumin is an independent predictor of functional outcome following an acute ischemic stroke and serum albumin level is inversely correlated with severity of stroke at presentation.

Download Full-text

Low Serum Albumin level as a Predictor of Hemorrhage Transformation after Intravenous Thrombolysis in Ischemic Stroke Patients

Scientific Reports ◽

10.1038/s41598-017-06802-y ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 11

Author(s):

Ruiwen Che ◽

Xiaoqin Huang ◽

Wenbo Zhao ◽

Fang Jiang ◽

Longfei Wu ◽

...

Keyword(s):

Ischemic Stroke ◽

Serum Albumin ◽

Serum Albumin Level ◽

Intravenous Thrombolysis ◽

Albumin Level ◽

Stroke Patients ◽

Low Serum

Download Full-text

SERUM ALBUMIN LEVEL AS A PREDICTOR OF ISCHEMIC STROKE OUTCOME

European Journal of Internal Medicine ◽

10.1016/s0953-6205(11)60208-2 ◽

2011 ◽

Vol 22 ◽

pp. S51

Author(s):

D. Koutete ◽

E. Koukou ◽

Em. Zoulias ◽

C. Karagiannis ◽

G. Kartelias ◽

...

Keyword(s):

Ischemic Stroke ◽

Serum Albumin ◽

Serum Albumin Level ◽

Albumin Level ◽

Stroke Outcome

Download Full-text

Serum Albumin as a Potential Predictor of Pneumonia after an Acute Ischemic Stroke

Current Neurovascular Research ◽

10.2174/1567202617666200514120641 ◽

2020 ◽

Vol 17 (4) ◽

pp. 385-393

Author(s):

Xue Yang ◽

Lu Wang ◽

Lukai Zheng ◽

Jiongxing Wu ◽

Junfeng Liu ◽

...

Keyword(s):

Logistic Regression ◽

Ischemic Stroke ◽

Serum Albumin ◽

Acute Ischemic Stroke ◽

Area Under The Curve ◽

Albumin Level ◽

Multivariate Logistic Regression ◽

Post Stroke ◽

Mild Stroke ◽

Univariate Analyses

Background: Serum albumin level is associated with infection after stroke, but whether albumin predicts post-stroke pneumonia is unclear. The potential relationship between albumin level and pneumonia in patients with acute ischemic stroke (AIS) was evaluated in this study. Methods: A consecutive sample of 798 AIS patients who were admitted to West China Hospital within 24 h after onset, from the year 2017 to 2018, were retrospectively analyzed. Blood was collected on admission and assayed for serum albumin. Univariate analyses, multivariate logistic regression, and stratified logistic regression were performed to identify the risk factors of post-stroke pneumonia. Results: Out of the 798 patients, 240 (30.2%) developed pneumonia at a median of 48 h after onset (interquartile range, 27-74 h). Patients with pneumonia had significantly lower serum albumin levels than those without pneumonia (40.6 vs. 42.9 g/l, p<0.001). After adjustment, the albumin level was still significantly associated with pneumonia in multivariate logistic regression (odds ratio [OR] 0.87, 95% confidence interval [CI] 0.81-0.94). The association between serum albumin and pneumonia tended to depend on National Institutes of Health Stroke Scale score (p = 0.045), but this was significant only in patients with mild stroke (OR 0.84, 95% CI 0.77-0.93). A dosedependent inverse relationship was found between albumin levels and the risk of pneumonia after AIS. Albumin values predicted pneumonia with an area under the curve of 0.661 (95% CI 0.620- 0.701), and the optimal cutoff was 42.6 g/L. Conclusion: Low serum albumin levels may be independent predictors of pneumonia in patients with AIS, especially in mild stroke. In fact, the risk of pneumonia may vary inversely with albumin level.

Download Full-text