Investigation of an Outbreak of Carbapenem-resistant Acinetobacter baumannii in the Medical Intensive Care Unit and Efficacy of Infection Control Measures

AbstractBetween November 1996 and February 1997, 17 episodes of vancomycin-resistant enterococci (VRE) infection or colonization (9 infections, 8 colonizations), all with the same or a similar genomic DNA pattern, were identified in the medical intensive care unit (MICU) of a tertiary-care cancer hospital. The cases were genotypically traced to a patient who was admitted to the hospital in September 1996 and who, by December 1996, had four different admissions to the MICU. Multifaceted infection control measures, including decontamination of the environment and of nondisposable equipment, halted the nosocomial transmission of VRE in the MICU.

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Active surveillance for carbapenem-resistant Acinetobacter baumannii in a medical intensive care unit: Can it predict and reduce subsequent infections and the use of colistin?

American Journal of Infection Control ◽

10.1016/j.ajic.2017.01.016 ◽

2017 ◽

Cited By ~ 3

Author(s):

Joon Hwan An ◽

Yu-Hyoung Kim ◽

Jeong-Eun Moon ◽

Jong Hae Jeong ◽

Soo-Hyun Kim ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Acinetobacter Baumannii ◽

Active Surveillance ◽

Medical Intensive Care Unit ◽

Carbapenem Resistant ◽

Medical Intensive Care

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An Outbreak of Carbapenem-Resistant Acinetobacter baumannii Infection in a Neonatal Intensive Care Unit: Investigation and Control

Infection Control and Hospital Epidemiology ◽

10.1086/657669 ◽

2011 ◽

Vol 32 (1) ◽

pp. 34-41 ◽

Cited By ~ 33

Author(s):

Eric J. McGrath ◽

Teena Chopra ◽

Nahed Abdel-Haq ◽

Katherine Preney ◽

Winston Koo ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Infection Control ◽

Neonatal Intensive Care Unit ◽

Acinetobacter Baumannii ◽

Neonatal Intensive Care ◽

Multidrug Resistant ◽

Control Measures ◽

Carbapenem Resistant ◽

Surveillance Cultures

Objective.To investigate the mode of transmission of and assess control measures for an outbreak of carbapenem-resistant (multidrug-resistant) Acinetobacter baumannii infection involving 6 premature infants.Design.An outbreak investigation based on medical record review was performed for each neonate during the outbreak (from November 2008 through January 2009) in conjunction with an infection control investigation.Setting.A 36-bed, level 3 neonatal intensive care unit in a university-affiliated teaching hospital in Detroit, Michigan.Interventions.Specimens were obtained for surveillance cultures from all infants in the unit. In addition, geographic cohorting of affected infants and their nursing staff, contact isolation, re-emphasis of adherence to infection control practices, environmental cleaning, and use of educational modules were implemented to control the outbreak.Results.Six infants (age, 10-197 days) with multidrug-resistant A. baumannii infection were identified. All 6 infants were premature (gestational age, 23-30 weeks) and had extremely low birth weights (birth weight, 1000 g or less). Conditions included conjunctivitis (2 infants), pneumonia (4 infants), and bacteremia (1 infant). One infant died of causes not attributed to infection with the organism; the remaining 5 infants were discharged home. All surveillance cultures of unaffected infants yielded negative results.Conclusions.The spread of multidrug-resistant A. baumannii infection was suspected to be due to staff members who spread the pathogen through close contact with infants. Clinical staff recognition of the importance of multidrug-resistant A. baumannii recovery from neonatal intensive care unit patients, geographic cohorting of infected patients, enhanced infection control practices, and staff education resulted in control of the spread of the organism.

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Completely Resistant Acinetobacter baumannii Strains

Infection Control and Hospital Epidemiology ◽

10.1086/502091 ◽

2002 ◽

Vol 23 (8) ◽

pp. 477-479 ◽

Cited By ~ 44

Author(s):

Siham Mahgoub ◽

Jimi Ahmed ◽

Aaron E. Glatt

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Infection Control ◽

Acinetobacter Baumannii ◽

Broad Spectrum ◽

Chart Review ◽

Retrospective Chart Review ◽

Control Measures ◽

Teaching Hospitals ◽

Infection Control Measures

Abstract Nosocomially acquired completely resistant Acinetobacter baumannii strains are a major clinical concern. We identified completely resistant A. baumannii in 6 (4.9%) of 122 A. baumannii isolates in a retrospective chart review at two teaching hospitals. All of these patients had received broad-spectrum antibiotics and had severe underlying comorbid illnesses, long hospitalizations, or recent surgical procedures; 3 had been in the intensive care unit. Five (83%) of the 6 patients were older than 70 years. Only one death occurred. Strict infection control measures may limit further spread.

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