A cost-effectiveness analysis of screening strategies for down syndrome (DS)

2004 ◽  
Vol 191 (6) ◽  
pp. S46
Author(s):  
Anthony Odibo ◽  
David Stamilio ◽  
Harish Sehdev ◽  
George Macones
Keyword(s):  
Down Syndrome ◽  
Cost Effectiveness ◽  
Cost Effectiveness Analysis ◽  
Effectiveness Analysis ◽  
Screening Strategies

A Cost-Effectiveness Analysis of Prenatal Screening Strategies for Down Syndrome

2005 ◽  
Vol 106 (3) ◽  
pp. 562-568 ◽  
Author(s):  
Anthony O. Odibo ◽  
David M. Stamilio ◽  
Deborah B. Nelson ◽  
Harish M. Sehdev ◽  
George A. Macones
Keyword(s):  
Down Syndrome ◽  
Cost Effectiveness ◽  
Prenatal Screening ◽  
Cost Effectiveness Analysis ◽  
Effectiveness Analysis ◽  
Screening Strategies

OP354 Cost-Effectiveness Analysis Of Different Prenatal Screening Strategies For Down Syndrome In China: Data From Shandong Province

2020 ◽  
Vol 36 (S1) ◽  
pp. 6-7
Author(s):  
Yanqiu Du ◽  
Wenru Shang ◽  
Jiayan Huang
Keyword(s):  
Down Syndrome ◽  
Cost Effectiveness ◽  
Pregnant Women ◽  
Prenatal Screening ◽  
Screening Strategy ◽  
Cost Effectiveness Analysis ◽  
Shandong Province ◽  
Tree Model ◽  
Effectiveness Analysis ◽  
Screening Strategies

IntroductionThere are large differences between the prenatal screening strategies for Down Syndrome (DS) in different provinces in China. In Henan province there is a serological triple screening in the second trimester (STS) strategy, while in Shandong province contingent non-invasive prenatal testing (NIPT) screening strategy (NIPT delivered to older pregnant women) is used, and there is a universal NIPT screening strategy in Anhui province. Moreover, many factors varied widely in different regions, such as the proportion of older pregnant woman and the ability of people to pay. This study aimed to determine the cost-effectiveness of current strategy in Shandong compared with strategies in other provinces.MethodsA decision tree model was developed according to the screening strategies in different provinces. Four screening strategies were involved, universal STS strategy, contingent STS strategy, contingent NIPT strategy, and universal NIPT strategy. Cost-effectiveness analysis was conducted from a societal perspective in a simulated cohort of 100,000 pregnant women. The data of costs and epidemiologic parameters were collected from field surveys in Shangdong and a literature review.ResultsThe universal STS strategy, contingent STS strategy, contingent NIPT strategy, and universal NIPT strategy could prevent 17.0, 40.0, 46.2, and 53.6 DS births, respectively. There was no strategy dominated by others. The universal NIPT strategy and contingent NIPT strategy would decrease invasive procedures for prenatal diagnosis, resulting in fewer procedure-related miscarriages. The sensitivity analysis showed that the effectiveness of the screening strategy is significantly influenced by the resident's acceptance of NIPT.ConclusionsFrom the perspective of maximizing the effect, the universal NIPT strategy is the optimal strategy. But taking into account the resident's and government's ability to pay, contingent NIPT Strategy may be appropriate for the current situation in Shandong. To ensure a better cost-effective advantage in the universal NIPT strategy, the government should provide health education to increase the acceptance of NIPT while controlling the price of NIPT.

A cost-effectiveness analysis of cell free DNA as a replacement for serum screening for Down syndrome

2015 ◽  
Vol 35 (5) ◽  
pp. 440-446 ◽  
Author(s):  
Brandon S. Walker ◽  
Brian R. Jackson ◽  
Danielle LaGrave ◽  
Edward R. Ashwood ◽  
Robert L. Schmidt
Keyword(s):  
Down Syndrome ◽  
Cost Effectiveness ◽  
Cost Effectiveness Analysis ◽  
Cell Free Dna ◽  
Free Dna ◽  
Effectiveness Analysis ◽  
Serum Screening
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