Repeated isoflurane exposure and neuroapoptosis in the midgestation fetal sheep brain

2016 ◽  
Vol 214 (4) ◽  
pp. 542.e1-542.e8 ◽  
Author(s):  
Olutoyin A. Olutoye ◽  
Fariha Sheikh ◽  
Irving J. Zamora ◽  
Ling Yu ◽  
Adesola C. Akinkuotu ◽  
...  
Keyword(s):  
Fetal Sheep ◽  
Sheep Brain

Intercellular barriers to and transcellular transfer of albumin in the fetal sheep brain

1997 ◽  
Vol 195 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Y. Balslev ◽  
K. M. Dziegielewska ◽  
K. Møllgård ◽  
N. R. Saunders
Keyword(s):  
Fetal Sheep ◽  
Sheep Brain

Effect of chronic hypoxemia on the regulation of nitric-oxide synthase in the fetal sheep brain

1998 ◽  
Vol 111 (2) ◽  
pp. 271-277 ◽  
Author(s):  
Kripamoy Aguan ◽  
Jun Murotsuki ◽  
Robert Gagnon ◽  
Loren P Thompson ◽  
Carl P Weiner
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Fetal Sheep ◽  
Sheep Brain ◽  
Chronic Hypoxemia ◽  
Oxide Synthase

Heat production of fetal sheep brain in utero

1977 ◽  
Vol 43 (4) ◽  
pp. 747-749 ◽  
Author(s):  
R. M. Abrams ◽  
J. F. Clapp ◽  
M. Notelovitz ◽  
T. Tyler ◽  
S. Cassin
Keyword(s):  
Specific Heat ◽  
Heat Production ◽  
Brain Temperature ◽  
Main Pulmonary Artery ◽  
Fetal Brain ◽  
In Utero ◽  
Total Occlusion ◽  
Fetal Sheep ◽  
Sheep Brain ◽  
Near Term

Thermojunctions were implanted in the brains of 10 near term fetal sheep in utero under halothane anesthesia. Brief total occlusion of fetal brachiocephalic artery was followed immediately by an increase in brain temperature (mean +/- SE) of 0.130 +/- 0.014 degrees C-min-1. Occlusion of main pulmonary artery and ascending aorta, simultaneously, led to a brain temperature increase of 0.144 +/- 0.018 degrees C-min-1. Specific heat of three fetal brains was determined to be 0.898 +/- 0.014 cal-g-1. degrees C-1 or 3.76 +/- 0.059 J-g-1. Rate of fetal brain heat production, computed as the product of the higher rate of temperature change and brain specific heat, was 0.129 +/- 0.014 cal-g-1-min-1 or 9.00 +/- 0.98 mW-g-1.

Cerebral metabolism in sheep: a comparative study of the adult, the lamb, and the fetus

1975 ◽  
Vol 229 (1) ◽  
pp. 235-239 ◽  
Author(s):  
Jones MD ◽  
LI Burd ◽  
EL Makowski ◽  
G Meschia ◽  
FC Battaglia
Keyword(s):  
Steady State ◽  
Comparative Study ◽  
Cerebral Metabolism ◽  
Lactate Production ◽  
Fetal Sheep ◽  
Sagittal Sinus ◽  
Sheep Brain ◽  
Beta Hydroxybutyrate ◽  
Arteriovenous Difference

The cerebral uptakes of glucose, oxygen, lactate, pyruvate, acetoacetate and beta-hydroxybutyrate were compared in the adult, the fetal, and the newborn sheep. Beginning 1-2 days after surgery, we withdrew samples simultaneously from an artery and from the sagittal sinus for up to 2 wk. At all ages glucose was the only substrate taken up in significant quantity relative to oxygen. The glucose-oxygen quotients were 0.98 less than 1.03 less than 1.08 in adults; 0.92 less than 0.99 less than 1.06 in lambs; 0.92 less than 0.98 less than 1.03 in fetuses. These quotients were not significantly different. There was a significant (P less than .05) arteriovenous difference for lactate in the adult (-0.031 mM), but not in the lamb or fetus. A significant (P less than .05) arteriovenous difference pyruvate was found in the adult (-0.013 mM) and in the fetus (-0.020 mM). The findings of a glucose-oxygen quotient of approximately 1 and the lack of significant lactate production in fetal sheep brain are consistent with the hypothesis that anerobic glycolysis is unimportant to the steady-state cerebral metabolism of the fetal sheep.

scholarly journals White Matter Injury Following Prolonged Free Radical Formation in the 0.65 Gestation Fetal Sheep Brain

2005 ◽  
Vol 58 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Anna-Karin Welin ◽  
Mats Sandberg ◽  
Anna Lindblom ◽  
Pernilla Arvidsson ◽  
Ulf A Nilsson ◽  
...  
Keyword(s):  
Free Radical ◽  
White Matter ◽  
Radical Formation ◽  
White Matter Injury ◽  
Fetal Sheep ◽  
Sheep Brain ◽  
Free Radical Formation

Glucose transporter proteins GLUT1 and GLUT3 like immunoreactivities in the fetal sheep brain are not reduced by maternal betamethasone treatment

2006 ◽  
Vol 403 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Iwa Antonow-Schlorke ◽  
Martin Ebert ◽  
Thomas Müller ◽  
Harald Schubert ◽  
Andrea Gschanes ◽  
...  
Keyword(s):  
Glucose Transporter ◽  
Fetal Sheep ◽  
Transporter Proteins ◽  
Sheep Brain ◽  
Glucose Transporter Proteins
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