scholarly journals Microbiota during fetal/early life are essential to later anti-viral immunity in pregnancy

2022 ◽  
Vol 226 (1) ◽  
pp. S581-S582
Author(s):  
David Moorshead ◽  
Maxim D. Seferovic ◽  
Kjersti M. Aagaard
Keyword(s):  
Early Life ◽  
Viral Immunity ◽  
In Pregnancy

Association of Environmental Exposures in Pregnancy and Early Life with Islet Autoimmunity Development in Children in Bavaria, Germany

2022 ◽  
Author(s):  
Mahnaz Badpa ◽  
Kathrin Wolf ◽  
Alexandra Schneider ◽  
Christiane Winkler ◽  
Florian Haupt ◽  
...  
Keyword(s):  
Early Life ◽  
Environmental Exposures ◽  
Islet Autoimmunity ◽  
In Pregnancy

scholarly journals Childhood cancer and traffic-related air pollution exposure in pregnancy and early life

2013 ◽  
Vol 2013 (1) ◽  
pp. 3811
Author(s):  
Julia Heck ◽  
Jun Wu ◽  
Christina Lombardi ◽  
Travis Meyers ◽  
Michelle Wilhelm ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Cancer ◽  
Early Life ◽  
Air Pollution Exposure ◽  
Pollution Exposure ◽  
In Pregnancy

scholarly journals Maternal and early life exposure to phthalates: The Plastics and Personal-care Products use in Pregnancy (P4) study

2016 ◽  
Vol 551-552 ◽  
pp. 344-356 ◽  
Author(s):  
Tye E. Arbuckle ◽  
Mandy Fisher ◽  
Susan MacPherson ◽  
Carly Lang ◽  
Gilles Provencher ◽  
...  
Keyword(s):  
Early Life ◽  
Personal Care Products ◽  
Personal Care ◽  
Early Life Exposure ◽  
In Pregnancy

Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial

The Lancet ◽  
2001 ◽  
Vol 358 (9277) ◽  
pp. 188-193 ◽  
Author(s):  
Adnan Custovic ◽  
Bridget M Simpson ◽  
Angela Simpson ◽  
Patricia Kissen ◽  
Ashley Woodcock
Keyword(s):  
Early Life ◽  
Respiratory Symptoms ◽  
Randomised Trial ◽  
First Year ◽  
Environmental Manipulation ◽  
First Year Of Life ◽  
In Pregnancy

T helper cell 2 immune skewing in pregnancy/early life: chemical exposure and the development of atopic disease and allergy

2015 ◽  
Vol 172 (3) ◽  
pp. 584-591 ◽  
Author(s):  
J.P. McFadden ◽  
J.P. Thyssen ◽  
D.A. Basketter ◽  
P. Puangpet ◽  
I. Kimber
Keyword(s):  
Early Life ◽  
Chemical Exposure ◽  
Atopic Disease ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
In Pregnancy

scholarly journals Childhood Cancer and Traffic-Related Air Pollution Exposure in Pregnancy and Early Life

2013 ◽  
Vol 121 (11-12) ◽  
pp. 1385-1391 ◽  
Author(s):  
Julia E. Heck ◽  
Jun Wu ◽  
Christina Lombardi ◽  
Jiaheng Qiu ◽  
Travis J. Meyers ◽  
...  
Keyword(s):  
Air Pollution ◽  
Childhood Cancer ◽  
Early Life ◽  
Air Pollution Exposure ◽  
Pollution Exposure ◽  
In Pregnancy

scholarly journals Multi-omics signatures of the human early life exposome

2021 ◽  
Author(s):  
Lea Maitre ◽  
Mariona Bustamante ◽  
Carles Hernandez-Ferrer ◽  
Denise Thiel ◽  
Chung-Ho E Lau ◽  
...  
Keyword(s):  
Indoor Air ◽  
Early Life ◽  
Biological Effects ◽  
Critical Role ◽  
Weather Conditions ◽  
Biological Responses ◽  
Essential Trace Elements ◽  
Life Course Health ◽  
Molecular Phenotypes ◽  
In Pregnancy

Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1,301 mother-child pairs, we associated individual exposomes consisting of >100 chemical, physical and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, metabolome and proteins) in childhood. We identified 1,170 associations, 249 in pregnancy and 921 in childhood, which revealed potential biological responses and sources of exposure. The methylome best captures the persistent influence of pregnancy exposures, including maternal smoking; while childhood exposures were associated with features from all omics layers, revealing novel signatures for indoor air quality, essential trace elements, endocrine disruptors and weather conditions. This study provides a unique resource (https://helixomics.isglobal.org/) to guide future investigation on the biological effects of the early life exposome.

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