Carcinoma ex pleomorphic adenoma in minor salivary glands of the anterior tongue: A case report

Abstract Introduction/Objective Myoepithelial carcinoma is identified by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. It occurs most commonly in the parotid gland followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Nasopharyngeal origin has been rarely reported. Methods/Case Report An afebrile 19-year-old female presented to the emergency department with persistent facial pressure, otalgia (right side greater than left side), rhinorrhea, and several episodes of epistaxis. One month before, she has been treated with Amoxicillin for three days with no relief, where Augmentin started for her for five days. About four days prior presentation, she was placed on Prednisone and Cefdinir. Over the next several days, she began having throat pain with difficulty swallowing. Routine blood work revealed a leukocytosis of 14.2 with normal differentiation. CT of the neck showed a large soft tissue mass centered at the right nasopharynx. Flexible nasal endoscopy performed bilaterally to reveal the nasopharynx is entirely obstructed with a lobulated mass filling the nasopharynx. On the right side, it extends into the posterior nasal passage filling the sphenoethmoid recess and the posterior floor of the nasal passage. Outpatient biopsy from nasopharynx mass is also performed. Results (if a Case Study enter NA) Mass biopsy reveals a mucinous and chondromyxoid background with mixed epithelial and myoepithelial differentiation. The is squamous metaplasia of myoepithelial cells and prominent mitotic activity and apoptotic activity. Immunohistochemistry was positive for CK5/6, calponin, BCL2, SMA, BerEp4, Sox10, and a proliferative index up to 40%. Based on this information Myoepithelial Carcinoma ex-pleomorphic adenoma of the nasopharynx is the diagnosis. Conclusion Carcinoma ex pleomorphic adenoma is usually a high-grade malignancy. It occurs most commonly in the parotid gland, followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Our case is one of the few cases of myoepithelial carcinoma arising in nasopharyngeal pleomorphic adenoma.

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Pleomorphic Adenoma of the Cervical Heterotopic Salivary Gland: A Case Report

Case Reports in Otolaryngology ◽

10.1155/2012/470652 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 2

Author(s):

Saman Vegari ◽

Masoud Naderpour ◽

Alireza Hemmati ◽

Hosein Baybordi

Keyword(s):

Salivary Gland ◽

Case Report ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Complete Resection ◽

Cervical Region ◽

Minor Salivary Glands ◽

Pathologic Evaluation ◽

Painless Mass

Introduction. Although pleomorphic adenoma is the most common neoplasm of the salivary glands, this tumor most commonly involves the minor salivary glands of palatal and rarely occurs in cervical region.Case Report. A 21-year-old female referred to our clinic due to painless mass of right upper region of neck. After paraclinical and pathologic evaluation, it was diagnosed as cervical pleomorphic adenoma.Conclusion. Pleomorphic adenoma may be rarely involving the neck. Although the prognosis is good, the choice treatment is the complete resection of the tumor.

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A Giant Pleomorphic Adenoma of the Palatine Arch in a 75-Year-Old Man: A Case Report with Review of Literature

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1213 ◽

2015 ◽

Vol 6 (1) ◽

pp. 23-25

Author(s):

Santosh Kumar Swain ◽

Mahesh Chandra Sahu ◽

Rajashree Tripathy

Keyword(s):

Case Report ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Soft Palate ◽

Benign Tumor ◽

Review Of Literature ◽

Minor Salivary Glands ◽

Common Benign Tumor ◽

Slow Growing ◽

Head Neck

ABSTRACT Pleomorphic adenoma (PA) is the most common benign tumor of the salivary glands and has both epithelial and mesenchymal tissues. It most commonly arises from the parotid or submandibular glands. Rarely, it arises from the minor salivary glands. We report here a case of pleomorphic adenoma arising from the soft palate and both sides of anterior tonsillar pillars in a 75-year-old man. This patient was presenting painless slow growing large swelling in the soft palate over 20 years causing mechanical obstruction of airway and food. The entire tumor mass was excised along with overlying mucosa. How to cite this article Swain SK, Sahu MC, Tripathy R. A Giant Pleomorphic Adenoma of the Palatine Arch in a 75-Year-Old Man: A Case Report with Review of Literature. Int J Head Neck Surg 2015;6(1):23-25.

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Carcinoma ex pleomorphic adenoma of minor salivary glands with major epithelial-myoepithelial component: clinicopathologic and immunohistochemical study of 3 cases

Annals of Diagnostic Pathology ◽

10.1016/j.anndiagpath.2015.03.011 ◽

2015 ◽

Vol 19 (3) ◽

pp. 164-168 ◽

Cited By ~ 8

Author(s):

Bruno Tavares Sedassari ◽

Harim Tavares dos Santos ◽

Fernanda Viviane Mariano ◽

Nelise Alexandre da Silva Lascane ◽

Albina Altemani ◽

...

Keyword(s):

Salivary Glands ◽

Pleomorphic Adenoma ◽

Immunohistochemical Study ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Minor Salivary Glands

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Ectopic carcinoma ex-pleomorphic adenoma in the lower neck: a rare entity at a rare location

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v20i1.50369 ◽

2021 ◽

Vol 20 (1) ◽

pp. 190-193

Author(s):

Kuganathan Ramasamy ◽

Yatiee Swany Lahuri ◽

Norhaslinda Abdul Gani ◽

Noor Hasni Shamsudin

Keyword(s):

Salivary Glands ◽

Pleomorphic Adenoma ◽

Medical Science ◽

Malignant Tumour ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Minor Salivary Glands ◽

Salivary Gland Tissue ◽

Gland Tissue ◽

Rare Location ◽

Lower Neck

Ectopic salivary gland tissue (ESGT) is salivary tissue located outside the major, minorand accessory salivary glands. Neoplasms rarely arise from ESGT, let alone carcinoma expleomorphicadenoma (CEPA) which is a malignant tumour that arises from the epithelialcomponent of pleomorphic adenoma. It usually occurs in the parotid gland and in lesserinstances, from submandibular gland or minor salivary glands. Herein, we report a rare caseof CEPA in right supraclavicular ESGT of a 67-year-old lady.She underwent complete surgicalexcision of the mass and is free from any recurrence to date. Brief review of pathogenesis,clinical features and treatment of ectopic CEPA are discussed. A thorough review of the Englishliterature reveals that our patient may be the second case of ectopic CEPA in the neck regionever reported to date. Bangladesh Journal of Medical Science Vol.20(1) 2021 p.190-193

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Pleomorphic Adenoma of Minor Salivary Glands: a Case Report

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2018.02.478 ◽

2018 ◽

Vol 126 (3) ◽

pp. e127

Author(s):

Ivan José Correia Neto ◽

Maria Augusta Cunha Lima Jucá ◽

Ivisson Alexandre Pereira Da Silva ◽

Milkle Bruno Pessoa Santos ◽

Yann Victor Paiva Bastos ◽

...

Keyword(s):

Case Report ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Minor Salivary Glands

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PLEOMORPHIC ADENOMA LEFT NOSE ALA IN 15 YRS OLD GIRL . A RARE CASE REPORT

10.36106/gjra/9101241 ◽

2021 ◽

pp. 33-34

Author(s):

Radhika Mucharla ◽

Praneeth kumar.K. ◽

Sumalatha Kasturi

Keyword(s):

Case Report ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Soft Palate ◽

Rare Case ◽

Benign Tumor ◽

Minor Salivary Glands ◽

Common Benign Tumor ◽

Pleomorphic Adenomas ◽

Rare Case Report

Pleomorphic adenomas are the most common benign tumor of major salivary glands. In addition, they may also occur in 1 minor salivary glands of hard and soft palate . Intranasal 2 pleomorphic adenomas are unusual .

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