scholarly journals Ectopic carcinoma ex-pleomorphic adenoma in the lower neck: a rare entity at a rare location

2021 ◽  
Vol 20 (1) ◽  
pp. 190-193
Author(s):  
Kuganathan Ramasamy ◽  
Yatiee Swany Lahuri ◽  
Norhaslinda Abdul Gani ◽  
Noor Hasni Shamsudin
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Medical Science ◽  
Malignant Tumour ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Minor Salivary Glands ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Rare Location ◽  
Lower Neck

Ectopic salivary gland tissue (ESGT) is salivary tissue located outside the major, minorand accessory salivary glands. Neoplasms rarely arise from ESGT, let alone carcinoma expleomorphicadenoma (CEPA) which is a malignant tumour that arises from the epithelialcomponent of pleomorphic adenoma. It usually occurs in the parotid gland and in lesserinstances, from submandibular gland or minor salivary glands. Herein, we report a rare caseof CEPA in right supraclavicular ESGT of a 67-year-old lady.She underwent complete surgicalexcision of the mass and is free from any recurrence to date. Brief review of pathogenesis,clinical features and treatment of ectopic CEPA are discussed. A thorough review of the Englishliterature reveals that our patient may be the second case of ectopic CEPA in the neck regionever reported to date. Bangladesh Journal of Medical Science Vol.20(1) 2021 p.190-193

scholarly journals Ectopic carcinoma ex-pleomorphic adenoma in the lower neck: a rare entity at a rare location

2021 ◽  
Vol 20 (3) ◽  
pp. 658-661
Author(s):  
Kuganathan Ramasamy ◽  
Yatiee Swany Lahuri ◽  
Norhaslinda Abdul Gani ◽  
Noor Hasni Shamsudin
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
English Literature ◽  
Medical Science ◽  
Neck Region ◽  
Surgical Excision ◽  
Malignant Tumour ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Complete Surgical Excision ◽  
Lower Neck

Ectopic salivary gland tissue (ESGT) is salivary tissue located outside the major, minor and accessory salivary glands. Neoplasms rarely arise from ESGT, let alone carcinoma expleomorphic adenoma (CEPA) which is a malignant tumour that arises from the epithelial component of pleomorphic adenoma. It usually occurs in the parotid gland and in lesser instances, from submandibular gland or minor salivary glands. Herein, we report a rare case of CEPA in right supraclavicular ESGT of a 67-year-old lady.She underwent complete surgical excision of the mass and is free from any recurrence to date. Brief review of pathogenesis, clinical features and treatment of ectopic CEPA are discussed. A thorough review of the English literature reveals that our patient may be the second case of ectopic CEPA in the neck region ever reported to date. Bangladesh Journal of Medical Science Vol.20(3) 2021 p.658-661

Carcinoma ex pleomorphic adenoma of minor salivary glands with major epithelial-myoepithelial component: clinicopathologic and immunohistochemical study of 3 cases

2015 ◽  
Vol 19 (3) ◽  
pp. 164-168 ◽  
Author(s):  
Bruno Tavares Sedassari ◽  
Harim Tavares dos Santos ◽  
Fernanda Viviane Mariano ◽  
Nelise Alexandre da Silva Lascane ◽  
Albina Altemani ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Immunohistochemical Study ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Minor Salivary Glands

scholarly journals USE OF 29A MICRO-RNA FOR DIAGNOSIS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS

2020 ◽  
Vol 20 (1) ◽  
pp. 149-154
Author(s):  
I. S. Brodetskyi ◽  
V.A. Malanchuk ◽  
V. E Dosenko
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Venous Blood ◽  
Micro Rna ◽  
Salivary Gland Tissue ◽  
Pleomorphic Adenomas ◽  
Gland Tissue ◽  
Benign Tumours

Introduction. Pleomorphic adenoma is known as the most common tumour in salivary glands that makes up 60-90% of all benign tumours of the salivary glands. The modern genetic tendency towards the diagnosis of salivary gland tumours is the study of the role of microRNA molecules, and miRNA-29a in the focus of the great researchers’ interest. It is expressed in 84 % of the pleomorphic adenomas of the salivary glands. Objectives. Determination of expression of miRNA-29a in tissues of pleomorphic adenomas of the large salivary glands that adjacent to the tumour of the tissue of the salivary gland, intact tissue of the salivary gland, was out of touch with the tumour and venous blood.  Materials and methods. The study included 20 patients with benign tumours of the large salivary glands (pleomorphic adenomas). The expression of miRNA-29a was evaluated by using reverse transcription and quantitative polymerase chain reaction (qPCR) in real time. Results. The analysis of the level of miRNA-29a expression revealed that among 4 groups of indicators (tumour tissue, tissues adjacent to the tumour salivary gland tissue, intact salivary gland, which was out of touch with the tumour and venous blood) in patients with pleomorphic adenoma of the large salivary gland, the highest expression was noted in the group, where salivary gland tissue was adjacent to the salivary gland tumour (111, 93±56, 97 versus 8,12±4,4). Correlation analysis of patients with pleomorphic adenoma of the large salivary glands with different fragments of tissues samples demonstrated that the expression level of miRNA-29a differed significantly between the groups (adjacent gland - intact salivary tissue). Conclusions. A sufficiently high level of miRNA-29a expression in the tissues of pleomorphic adenoma in the large salivary glands compared with the normal (intact salivary gland tissue), 10 times as much can be used as a genetic marker for verification (identification) of this type of tumours. Studies of biopsy material from patients with pleomorphic adenoma in the large salivary glands at the genetic level (by expression of miRNAs-29a) confirm the need not only in enucleating of the tumour (partial parotidectomy), but also in performing of subtotal resection with removal of salivary gland adjacent to the tumour.

scholarly journals Carcinoma ex pleomorphic adenoma in minor salivary glands of the anterior tongue: A case report

2013 ◽  
Vol 25 (2) ◽  
pp. 197-200 ◽  
Author(s):  
Shin-ichi Yamada ◽  
Souichi Yanamoto ◽  
Satoshi Rokutanda ◽  
Kouhei Matsutani ◽  
Goro Kawasaki ◽  
...  
Keyword(s):  
Case Report ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Minor Salivary Glands

Myoepithelial Carcinoma ex Pleomorphic Adenoma: Rare Case Report with Clinicopathologic and Immunohistochemical Features

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S86-S87
Author(s):  
M Khazaeli ◽  
Z Kamaluddin ◽  
M Taherian
Keyword(s):  
Case Report ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Nasal Passage ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Sublingual Gland ◽  
Myoepithelial Carcinoma ◽  
Minor Salivary Glands ◽  
Myoepithelial Differentiation ◽  
The Right

Abstract Introduction/Objective Myoepithelial carcinoma is identified by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. It occurs most commonly in the parotid gland followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Nasopharyngeal origin has been rarely reported. Methods/Case Report An afebrile 19-year-old female presented to the emergency department with persistent facial pressure, otalgia (right side greater than left side), rhinorrhea, and several episodes of epistaxis. One month before, she has been treated with Amoxicillin for three days with no relief, where Augmentin started for her for five days. About four days prior presentation, she was placed on Prednisone and Cefdinir. Over the next several days, she began having throat pain with difficulty swallowing. Routine blood work revealed a leukocytosis of 14.2 with normal differentiation. CT of the neck showed a large soft tissue mass centered at the right nasopharynx. Flexible nasal endoscopy performed bilaterally to reveal the nasopharynx is entirely obstructed with a lobulated mass filling the nasopharynx. On the right side, it extends into the posterior nasal passage filling the sphenoethmoid recess and the posterior floor of the nasal passage. Outpatient biopsy from nasopharynx mass is also performed. Results (if a Case Study enter NA) Mass biopsy reveals a mucinous and chondromyxoid background with mixed epithelial and myoepithelial differentiation. The is squamous metaplasia of myoepithelial cells and prominent mitotic activity and apoptotic activity. Immunohistochemistry was positive for CK5/6, calponin, BCL2, SMA, BerEp4, Sox10, and a proliferative index up to 40%. Based on this information Myoepithelial Carcinoma ex-pleomorphic adenoma of the nasopharynx is the diagnosis. Conclusion Carcinoma ex pleomorphic adenoma is usually a high-grade malignancy. It occurs most commonly in the parotid gland, followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Our case is one of the few cases of myoepithelial carcinoma arising in nasopharyngeal pleomorphic adenoma.

scholarly journals Pleomorphic Adenoma of the Cervical Heterotopic Salivary Gland: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Saman Vegari ◽  
Masoud Naderpour ◽  
Alireza Hemmati ◽  
Hosein Baybordi
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Complete Resection ◽  
Cervical Region ◽  
Minor Salivary Glands ◽  
Pathologic Evaluation ◽  
Painless Mass

Introduction. Although pleomorphic adenoma is the most common neoplasm of the salivary glands, this tumor most commonly involves the minor salivary glands of palatal and rarely occurs in cervical region.Case Report. A 21-year-old female referred to our clinic due to painless mass of right upper region of neck. After paraclinical and pathologic evaluation, it was diagnosed as cervical pleomorphic adenoma.Conclusion. Pleomorphic adenoma may be rarely involving the neck. Although the prognosis is good, the choice treatment is the complete resection of the tumor.

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