scholarly journals Müller Cell–Localized G-Protein–Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways

2019 ◽  
Vol 189 (9) ◽  
pp. 1878-1896 ◽  
Author(s):  
Ankush Madaan ◽  
Prabhas Chaudhari ◽  
Mathieu Nadeau-Vallée ◽  
David Hamel ◽  
Tang Zhu ◽  
...  
Keyword(s):  
G Protein ◽  
Müller Cell ◽  
Retinal Vasculature ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid ◽  
Wnt Pathways ◽  
Muller Cell ◽  
G Protein Coupled

scholarly journals Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Anna Peters ◽  
Philipp Rabe ◽  
Petra Krumbholz ◽  
Hermann Kalwa ◽  
Robert Kraft ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid ◽  
Biased Signaling ◽  
G Protein Coupled

scholarly journals The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

2015 ◽  
Vol 93 (7) ◽  
pp. 1045-1055 ◽  
Author(s):  
Cecilie Morland ◽  
Knut Husø Lauritzen ◽  
Maja Puchades ◽  
Signe Holm-Hansen ◽  
Krister Andersson ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Hydroxycarboxylic Acid ◽  
G Protein Coupled

TGR5 in inflammation and cardiovascular disease

2014 ◽  
Vol 42 (2) ◽  
pp. 244-249 ◽  
Author(s):  
Thijs W.H. Pols
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Animal Studies ◽  
Nuclear Factor Κb ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
Glucagon Like Peptide 1 ◽  
Membrane Type ◽  
G Protein Coupled

TGR5 (Takeda G-protein-coupled receptor 5) [also known as GPBAR1 (G-protein-coupled bile acid receptor 1), M-BAR (membrane-type receptor for bile acids) or GPR131 (G-protein-coupled receptor 131)] is a G-protein-coupled receptor that was discovered as a bile acid receptor. TGR5 has specific roles in several tissues, among which are the regulation of energy expenditure, GLP-1 (glucagon-like peptide 1) secretion and gall bladder filling. An accumulating body of evidence now demonstrates that TGR5 also acts in a number of processes important in inflammation. Most striking in this context are several observations that TGR5 signalling curbs the inflammatory response of macrophages via interfering with NF-κB (nuclear factor κB) activity. In line with this, recent animal studies also suggest that TGR5 could be exploited as a potential target for intervention in a number of inflammation-driven diseases, including atherosclerosis. In the present paper, I review our current understanding of TGR5 with a strong focus on its potential as target for intervention in inflammation-driven diseases.

scholarly journals Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein–Coupled Receptor 120

2016 ◽  
Vol 89 (5) ◽  
pp. 505-520 ◽  
Author(s):  
Rudi Prihandoko ◽  
Elisa Alvarez-Curto ◽  
Brian D. Hudson ◽  
Adrian J. Butcher ◽  
Trond Ulven ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Free Fatty Acid Receptor ◽  
G Protein Coupled ◽  
Fatty Acid Receptor
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