M232 ANAPHYLAXIS TO UNDERCOOKED SHRIMP IN A PATIENT SENSITIZED TO DUST MITES AND COCKROACH

Beberapa kasus urtikaria pada paparan debu dan diantaranya menghubungkan sensitivitas tungau debu rumah (TDR) dengan urtikaria berdasarkan riwayat pasien dan pemeriksaan uji intradermal. Tujuan penelitian ini adalah menentukan korelasi antara kepadatan TDR dan rekurensi urtikaria. Jumlah sampel pada penelitian ini 30 orang. Kepadatan TDR dari tiap kamar sampel dihitung dengan mengumpulkan debu, dan sampel dinilai sensitivitas terhadao TDR dengan pemeriksaan skin prick test (SPT). Diagnosis urtikaria berdasarkan anamnesis, kemudian ditanyaan rekurensinya dalam tiga bulan terakhir. Hasil: Dari 30 peserta, tujuh (23,3%) sampel memiliki kepadatan TDR sedang sementara 23 (76,7%) memiliki kepadatan rendah. Selain itu, 15 sampel positif SPT terhadap alergen TDR. Dari anamnesis, 12 (40%) sampel didiagnosis urtikaria dan diantaranya, 11 orang (91,67%) positif terhadap SPT. Tidak ada sampel yang memiliki rekurensi urtikaria dalam tiga bulan terakhir. Kesimpulan: Meskipun penelitian ini tidak menunjukkan korelasi yang signifikan antara kepadatan TDR dan tingkat kekambuhan urtikaria (p> 0,05), TDR memang bisa memicu eksaserbasi. Penelitian ini membutuhkan penyelidikan lebih lanjut dengan ukuran sampel yang lebih besar.

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Efficacy and safety of sublingual immunotherapy in elderly rhinitis patients sensitized to house dust mites

10.26226/morressier.5acdc661d462b8029238d880 ◽

2018 ◽

Author(s):

Ji Hye Kim

Keyword(s):

House Dust ◽

Sublingual Immunotherapy ◽

House Dust Mites ◽

Dust Mites ◽

Efficacy And Safety

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Faculty Opinions recommendation of House dust mites induce proliferation of severe asthmatic smooth muscle cells via an epithelium-dependent pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725301281.793514991 ◽

2016 ◽

Author(s):

James Martin

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cells ◽

House Dust ◽

Muscle Cells ◽

House Dust Mites ◽

Dust Mites ◽

Severe Asthmatic ◽

Dependent Pathway

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НЕКОТОРЫЕ ОСОБЕННОСТИ РАСПРОСТРАНЕННОСТИ РЕСПИРАТОРНОЙ АЛЛЕРГИИ НА ЮГЕ РОССИИ

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/raj.2019.1-1.53219 ◽

2019 ◽

Author(s):

D.Sh. Macharadze

Keyword(s):

Dominant Role ◽

Pollen Allergy ◽

Respiratory Allergy ◽

House Dust Mites ◽

Dust Mites ◽

The Past ◽

Regional Features ◽

Respiratory Allergies ◽

Southern Russia

В обзорной статье приведены данные по распространенности респираторной аллергии - аллергического ринита и бронхиальной астмы на юге России, опубликованные за последние десятилетия. Показана доминирующая роль пыльцевой аллергии практически во всем южном регионе России. В Чеченской Республике у больных респираторной аллергией обнаружена сходная частота встречаемости сенсибилизации к клещам домашней пыли и пыльце злаковых трав (51,1 и 52,5 соответственно), тогда как сенсибилизация к пыльце амброзии и полыни встречалась в 3 раза реже (26,6 и 20,7 соответственно) по сравнению с соседними регионами юга России. Эти данные демонстрируют климатогеографические, экологические и другие региональные особенности в распространении респираторной аллергии.The review article presents data on the prevalence of respiratory allergy - allergic rhinitis and bronchial asthma in southern Russia, published over the past decades. The dominant role of pollen allergy is shown in almost the entire southern region of Russia. In the Chechen Republic, sensitization to house dust mites and grass pollen was found in patients with respiratory allergy equally (51.1 and 52.5, respectively), whereas ragweed and mugwort sensitization was 3 times less (26.6 and 20.7, respectively) compared with the neighboring regions of southern Russia. These data demonstrate climate-geographical, environmental and other regional features in the prevalence of respiratory allergies.

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Insect Allergens on the Dining Table

Current Protein and Peptide Science ◽

10.2174/1389203720666190715091951 ◽

2020 ◽

Vol 21 (2) ◽

pp. 159-169 ◽

Cited By ~ 2

Author(s):

Kyoung Yong Jeong ◽

Jung-Won Park

Keyword(s):

Food Processing ◽

Adverse Reactions ◽

Arginine Kinase ◽

House Dust Mites ◽

Food Allergies ◽

Edible Insects ◽

Dust Mites ◽

Edible Insect ◽

Respiratory Allergies ◽

Inhalant Allergens

Edible insects are important sources of nutrition, particularly in Africa, Asia, and Latin America. Recently, edible insects have gained considerable interest as a possible solution to global exhaustion of the food supply with population growth. However, little attention has been given to the adverse reactions caused by insect consumption. Here, we provide an overview of the food allergens in edible insects and offer insights for further studies. Most of the edible insect allergens identified to date are highly cross-reactive invertebrate pan-allergens such as tropomyosin and arginine kinase. Allergic reactions to these allergens may be cross-reactions resulting from sensitization to shellfish and/or house dust mites. No unique insect allergen specifically eliciting a food allergy has been described. Many of the edible insect allergens described thus far have counterpart allergens in cockroaches, which are an important cause of respiratory allergies, but it is questionable whether inhalant allergens can cause food allergies. Greater effort is needed to characterize the allergens that are unique to edible insects so that safe edible insects can be developed. The changes in insect proteins upon food processing or cooking should also be examined to enhance our understanding of edible insect food allergies.

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PILOT STUDY OF IFN-γ-INDUCED SPECIFIC HYPOSENSITIZATION FOR HOUSE DUST MITES IN ATOPIC DERMATITIS: IFN-γ-INDUCED IMMUNE DEVIATION AS A NEW THERAPEUTIC CONCEPT FOR ATOPIC DERMATITIS

Cytokine ◽

10.1006/cyto.1999.0589 ◽

2000 ◽

Vol 12 (5) ◽

pp. 472-476 ◽

Cited By ~ 14

Author(s):

Geunwoong Noh ◽

Ki Young Lee

Keyword(s):

Atopic Dermatitis ◽

Pilot Study ◽

House Dust ◽

House Dust Mites ◽

Dust Mites ◽

Immune Deviation ◽

Therapeutic Concept ◽

Specific Hyposensitization ◽

Ifn Γ

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Impact of Polyvalent Mechanical Bacterial Lysate on lymphocyte number and activity in asthmatic children: a randomized controlled trial

Allergy Asthma & Clinical Immunology ◽

10.1186/s13223-020-00503-4 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Małgorzata Bartkowiak-Emeryk ◽

Andrzej Emeryk ◽

Jacek Roliński ◽

Ewelina Wawryk-Gawda ◽

Ewa Markut-Miotła

Keyword(s):

T Lymphocytes ◽

Allergic Asthma ◽

Respiratory Infections ◽

Controlled Trial ◽

Trial Registration ◽

House Dust Mites ◽

Dust Mites ◽

Bacterial Lysate ◽

Clinical Trial Registration ◽

Asthmatic Children

Abstract Background Polyvalent Mechanical Bacterial Lysate (PMBL®) contains antigens of bacteria responsible for respiratory infections. PMBL® has been proven to reduce the number of respiratory infections, and in its use, immunological benefits have been seen in allergic patients. PMBL® activates both innate and specific immune responses. The lysate induces dendritic cells, T and B lymphocytes and IgA secretion, as well as the production of antibodies directed against administered bacterial antigens. Moreover, it increases the response against other bacteria and viruses. The immunologic mechanism of lysate’s action is not yet clearly determined. The objective of this study was to assess the effect of PMBL® on T cells in children with allergic asthma. Methods This study was a part of the EOLIA study. Herein, 49 children with allergic asthma and house dust mites allergy were included: 21 in PMBL® and 28 in the Placebo group, both, drug and placebo were administered sublingually. The tests were done at baseline and 12 weeks after the last tablet intake. The lymphocytes CD45+, lymphocytes T CD3+, CD3+CD25+, CD3+CD69+, Th CD3+CD4+, CD4+CD25+, CD4+CD25+ high, CD4+CD69+, Treg CD4+CD25+FOXP3, Tc CD3+CD8+, CD8+CD25+, CD8+CD69+, NK-like T CD3+CD16+CD56+ and NK cells CD3−CD16+CD56+ were described. Results At baseline, no significant differences between groups relative to blood count cells were observed, except for eosinophils. After 12 weeks, we observed an increase of T lymphocytes count. In addition, CD4+CD25+FOXP3+, CD8+ and CD3−CD16+CD56+ and (insignificantly) Th count increased. However, CD69+ and CD25+ subset of CD3+ significantly decreased. Conclusions The EOLIA study demonstrated that PMBL® administration 10 days per month for 3 months changed the panel of T lymphocytes. Trial registration Clinical Trial Registration: This study was a part of the EOLIA (Efficacy Of mechanical bacterial Lysate In Allergic children), a clinical study NCT02541331. Frederic Durmont, MD Lallemand Pharma International AG. Date of registration 09/08/2013. URL of trial registry record: https://clinicaltrials.gov/ct2/show/study/NCT02541331.

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