FISH analyses for 1p and 19q status on gliomas: Reporting an 8 years' experience from a tertiary care center in the Middle East

Author(s):  
Elie Massaad ◽  
Abeer Tabbarah ◽  
Mamdouha Barmada ◽  
Jean Rbeiz ◽  
Selim Nasser ◽  
...  
2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Deborah Mukherji ◽  
Marilyne Daher ◽  
Talar Telvizian ◽  
Christelle Dagher ◽  
Zahi Abdul-Sater ◽  
...  

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 73-73
Author(s):  
Mona Hassan ◽  
Talar Telvizian ◽  
Mostafa Abohelwa ◽  
Hadi Skouri ◽  
Deborah Mukherji

73 Background: Androgen deprivation therapy (ADT) is the mainstay of treatment for advanced prostate cancer, improving symptoms and prolonging survival. There is an association between ADT use and cardiovascular events, particularly in men with pre-existing risk factors. There are no definite guidelines to stratify patients based on cardiovascular risk prior to ADT initiation. This is the first study on cardiac risks and events in patients on ADT from Lebanon and the Middle East region, a population known to have a high prevalence of cardiovascular risk factors. Methods: A retrospective chart review of 236 patients with prostate cancer who received ADT therapy at a tertiary care center in Lebanon was performed. 167 had a full set of data and were included in analysis. Cardiovascular risk factors at baseline and cardiovascular events on ADT were reviewed. Results: The median age of our cohort was 68, range 48-92 years. The majority of patients had stage 4 diseases at diagnosis (49.8%) with a median duration of 12 months on ADT. In our cohort 24.4% had body mass index > 30, 52.1% had smoking history, 27.4% were diabetic, 28.8 % had history of coronary artery disease, 10.6% had heart failure history and 54.6% had hypertension. Less than half of the patients had a documented lipid profile at baseline. Twenty two patients (9.5%) had documented cardiac events following ADT initiation. Conclusions: In this cohort of patients from the Middle East we found that one third of the population had established coronary artery disease at baseline and 9.5% had documented cardiac events on ADT initiation. Our study highlights the gaps in cardiovascular risk assessment for this high risk group of patients with prostate cancer. Risk and resource-stratified algorithms are needed before starting ADT therapy for optimal cardiovascular health. Increased awareness, collaboration and referral mechanisms between oncologists, urologist and cardiologists are also needed.


2020 ◽  
Vol 195 ◽  
pp. 105846
Author(s):  
Hazem I. Assi ◽  
Lara Hilal ◽  
Ibrahim Abu-Gheida ◽  
Juliett Berro ◽  
Fares Sukhon ◽  
...  

Hemoglobin ◽  
2020 ◽  
Vol 44 (4) ◽  
pp. 278-283
Author(s):  
Rayan Bou-Fakhredin ◽  
Nadim N. Ghanem ◽  
Firas Kreidieh ◽  
Rami Tabbikha ◽  
Hisham Daadaa ◽  
...  

2021 ◽  
pp. 1-9
Author(s):  
Omar Najjar ◽  
Naji AbouChebel ◽  
Carine Zeeni ◽  
Marwan W. Najjar

<b><i>Background:</i></b> Despite advancements in craniosynostosis surgery, open surgical approaches remain crucial for the management of infants &#x3e;6 months of age and in those with complex synostosis. The clinical features of craniosynostosis remain poorly characterized in the Middle East. This study sought to assess the clinical features and outcomes of infants undergoing craniosynostosis surgery at a tertiary care center in Lebanon. <b><i>Methods:</i></b> A retrospective review was performed of all patients who underwent craniosynostosis surgery from December 2006 to December 2018 at the American University of Beirut Medical Center, Lebanon. Clinicodemographic characteristics, complications, and recurrence outcomes were recorded and evaluated using descriptive statistics. <b><i>Results:</i></b> Thirty-five infants met the inclusion criteria, with a mean age of 9.0 ± 4.0 months. The most common site of suture involvement was metopic (28.6%), followed by unilateral coronal (25.7%), sagittal (20.0%), bicoronal (8.6%), and multiple sites (17.1%). Five patients (14.3%) had syndromic synostosis. Median estimated blood loss was 200 mL, and median volume of transfused packed red blood cells was 180 mL. Two patients (5.7%) experienced postoperative complications, including postoperative blood transfusion (<i>n</i> = 1)and wire protrusion requiring removal (<i>n</i> = 1). Three patients (8.6%) required reoperation: 2 (5.7%) for resynostosis and 1 for traumatic fracture repair. Caregivers of all patients reported high satisfaction with cosmetic outcomes 4 weeks postoperatively. <b><i>Conclusions:</i></b> With appropriate perioperative precautions, open craniosynostosis surgery can be performed with minimal complications, low recurrence rates, and satisfactory cosmetic outcomes. Additional population-level data are needed to better characterize craniosynostosis patterns and outcomes in the Middle East.


2020 ◽  
Vol 197 ◽  
pp. 106170 ◽  
Author(s):  
Charbel Moussalem ◽  
Louna Ftouni ◽  
Zaki Abou Mrad ◽  
Ali Amine ◽  
Dima Hamideh ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document