Emergency department visits for outpatient adverse drug events: Demonstration for a national surveillance system

2005 ◽  
Vol 45 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Daniel S. Budnitz ◽  
Daniel A. Pollock ◽  
Aaron B. Mendelsohn ◽  
Kelly N. Weidenbach ◽  
Arthur K. McDonald ◽  
...  
2008 ◽  
Vol 152 (3) ◽  
pp. 416-421.e2 ◽  
Author(s):  
Adam L. Cohen ◽  
Daniel S. Budnitz ◽  
Kelly N. Weidenbach ◽  
Daniel B. Jernigan ◽  
Thomas J. Schroeder ◽  
...  

JAMA ◽  
2006 ◽  
Vol 296 (15) ◽  
pp. 1858 ◽  
Author(s):  
Daniel S. Budnitz ◽  
Daniel A. Pollock ◽  
Kelly N. Weidenbach ◽  
Aaron B. Mendelsohn ◽  
Thomas J. Schroeder ◽  
...  

2018 ◽  
Vol 8 (5) ◽  
pp. 384-391 ◽  
Author(s):  
Maribeth C Lovegrove ◽  
Andrew I Geller ◽  
Katherine E Fleming-Dutra ◽  
Nadine Shehab ◽  
Mathew R P Sapiano ◽  
...  

Abstract Background Antibiotics are among the most commonly prescribed medications for children; however, at least one-third of pediatric antibiotic prescriptions are unnecessary. National data on short-term antibiotic-related harms could inform efforts to reduce overprescribing and to supplement interventions that focus on the long-term benefits of reducing antibiotic resistance. Methods Frequencies and rates of emergency department (ED) visits for antibiotic adverse drug events (ADEs) in children were estimated using adverse event data from the National Electronic Injury Surveillance System–Cooperative Adverse Drug Event Surveillance project and retail pharmacy dispensing data from QuintilesIMS (2011–2015). Results On the basis of 6542 surveillance cases, an estimated 69464 ED visits (95% confidence interval, 53488–85441) were made annually for antibiotic ADEs among children aged ≤19 years from 2011 to 2015, which accounts for 46.2% of ED visits for ADEs that results from systemic medication. Two-fifths (40.7%) of ED visits for antibiotic ADEs involved a child aged ≤2 years, and 86.1% involved an allergic reaction. Amoxicillin was the most commonly implicated antibiotic among children aged ≤9 years. When we accounted for dispensed prescriptions, the rates of ED visits for antibiotic ADEs declined with increasing age for all antibiotics except sulfamethoxazole-trimethoprim. Amoxicillin had the highest rate of ED visits for antibiotic ADEs among children aged ≤2 years, whereas sulfamethoxazole-trimethoprim resulted in the highest rate among children aged 10 to 19 years (29.9 and 24.2 ED visits per 10000 dispensed prescriptions, respectively). Conclusions Antibiotic ADEs lead to many ED visits, particularly among young children. Communicating the risks of antibiotic ADEs could help reduce unnecessary prescribing. Prevention efforts could target pediatric patients who are at the greatest risk of harm.


2021 ◽  
pp. 105394
Author(s):  
Ralciane P. Menezes ◽  
Sávia G.O. Melo ◽  
Murilo B. Oliveira ◽  
Felipe F. Silva ◽  
Priscila G.V. Alves ◽  
...  

2013 ◽  
Vol 58 (4) ◽  
Author(s):  
Rusłan Sałamatin ◽  
Tamara Pavlikovska ◽  
Olga Sagach ◽  
Svitlana Nikolayenko ◽  
Vadim Kornyushin ◽  
...  

AbstractThe filarial nematode Dirofilaria repens is currently considered to be one of the most extensively spreading human and animal parasites in Europe. In Ukraine, reporting cases of dirofilariasis has been mandatory since 1975, and the disease was included in the national surveillance system for notifiable diseases. Up until December 31st 2012, a total of 1533 cases have been registered, with 1465 cases occurring within the previous 16 years. Most of the cases of dirofilariasis were registered in 6 regions: Kyiv, and the Donetsk, Zaporizhzhya, Dnipropetrovsk, Kherson and Chernihiv oblasts. In the years 1997–2002 the highest incidence rate was noted in the Kherson oblast in the south of the country (9.79 per 100 000 people), and the lowest in western Ukraine (0.07–1.68 per 100 000 people). D. repens infections were registered in all oblasts. Parasitic lesions were most often located in the head, the subconjunctival tissue and around the eyes. D. repens lesions were also found in the limbs, torso, male sexual organs, and female mammary glands. Dirofilariasis was diagnosed in persons aged from 11 months to 90 years old, most often among people between 21–40 years of age. Most patients had only one parasitic skin lesion; the majority of isolated nematodes were female. The results of our analysis point to a constant increase in D. repens dirofilariasis incidence in humans in Ukraine. Despite educational efforts, infections have become more frequent and the territory in which the disease occurs has enlarged to encompass the whole of Ukraine. Nevertheless, the Ukrainian sanitary-epidemiological services managed to achieve some measure of success, e.g. by creating a registration system for D. repens infections and establishing proper diagnostics for the disease.


JAMA ◽  
2016 ◽  
Vol 316 (20) ◽  
pp. 2115 ◽  
Author(s):  
Nadine Shehab ◽  
Maribeth C. Lovegrove ◽  
Andrew I. Geller ◽  
Kathleen O. Rose ◽  
Nina J. Weidle ◽  
...  

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S629-S629
Author(s):  
Niccolo Buetti ◽  
Andrew Atkinson ◽  
Nicolas Troillet ◽  
Marie-Christine Eisenring ◽  
Marcel Zwahlen ◽  
...  

2018 ◽  
Vol 93 (6) ◽  
Author(s):  
Marilyn J. Manco‐Johnson ◽  
Vanessa R. Byams ◽  
Michael Recht ◽  
Becky Dudley ◽  
Brandi Dupervil ◽  
...  

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