Neurodevelopmental outcomes in young children exposed to dental amalgam

2021 ◽  
Vol 61 ◽  
pp. 20
Author(s):  
GE Watson ◽  
GJ Myers ◽  
SW Thurston ◽  
D Harrington ◽  
CF Shamlaye ◽  
...  
Keyword(s):  
Young Children ◽  
Dental Amalgam ◽  
Neurodevelopmental Outcomes

Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy.

1994 ◽  
Vol 12 (6) ◽  
pp. 1212-1216 ◽  
Author(s):  
A Gajjar ◽  
R K Mulhern ◽  
R L Heideman ◽  
R A Sanford ◽  
E C Douglass ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Young Children ◽  
Surgical Resection ◽  
Residual Disease ◽  
Young Patients ◽  
Primary Chemotherapy ◽  
Neurodevelopmental Outcomes ◽  
Response To Chemotherapy ◽  
Disease Free

PURPOSE To evaluate survival and neurodevelopmental outcomes following radiation therapy in infants and young children with residual or progressive medulloblastoma after primary chemotherapy. PATIENTS AND METHODS Thirteen young patients (< or = 36 months old) with medulloblastoma were treated with preirradiation multiagent chemotherapy and maximal surgical resection. Patients were scheduled to receive radiation therapy at the time of documented disease progression or upon completion of chemotherapy with residual disease. All patients underwent neurodevelopmental evaluation at the time of diagnosis, before receiving radiation therapy, and at yearly intervals posttreatment. RESULTS Two patients completed the scheduled chemotherapy with residual disease and received delayed radiation therapy. The remaining 11 patients had either local or leptomeningeal progression during chemotherapy (median time to progression, 5 months). Six patients had a complete response (CR) to radiation therapy, and three of these children are alive 48 to 104 months postdiagnosis. Of the five patients who had progressive disease (PD) during radiation therapy or residual imaging abnormalities after treatment, only one is alive (with stable enhancing leptomeningeal abnormalities) 48 months postirradiation. Two additional survivors were rendered disease-free by surgical resection before radiation therapy and are without evidence of disease at 91 and 107 months after diagnosis. Thus, six of 13 patients are alive at 48 to 107 months postdiagnosis. Neurodevelopmental scores tended to be below age norms at diagnosis; scores improved during chemotherapy, but then decreased during posttreatment follow-up evaluation. CONCLUSION Radiation therapy appears to produce long-term disease-free survival in a proportion of very young patients who have progressive or residual medulloblastoma during or after primary chemotherapy. However, neurodevelopmental deficits are frequent among long-term survivors.

scholarly journals Prenatal exposure to dental amalgam in the Seychelles Child Development Nutrition Study: Associations with neurodevelopmental outcomes at 9 and 30 months

2012 ◽  
Vol 33 (6) ◽  
pp. 1511-1517 ◽  
Author(s):  
Gene E. Watson ◽  
Katie Evans ◽  
Sally W. Thurston ◽  
Edwin van Wijngaarden ◽  
Julie M.W. Wallace ◽  
...  
Keyword(s):  
Child Development ◽  
Prenatal Exposure ◽  
Dental Amalgam ◽  
Neurodevelopmental Outcomes ◽  
Nutrition Study

Neurodevelopmental outcomes in young children born to HIV-positive mothers in rural Yunnan, China

2018 ◽  
Vol 60 (7) ◽  
pp. 618-625 ◽  
Author(s):  
Jie Wu ◽  
Jing Li ◽  
Yan Li ◽  
Kek Khee Loo ◽  
Haixia Yang ◽  
...  
Keyword(s):  
Young Children ◽  
Hiv Positive ◽  
Neurodevelopmental Outcomes ◽  
Hiv Positive Mothers

scholarly journals Neurodevelopmental outcomes at 5 years in children exposed prenatally to maternal dental amalgam: The Seychelles Child Development Nutrition Study

2013 ◽  
Vol 39 ◽  
pp. 57-62 ◽  
Author(s):  
Gene E. Watson ◽  
Edwin van Wijngaarden ◽  
Tanzy M.T. Love ◽  
Emeir M. McSorley ◽  
Maxine P. Bonham ◽  
...  
Keyword(s):  
Child Development ◽  
Dental Amalgam ◽  
Neurodevelopmental Outcomes ◽  
Nutrition Study

scholarly journals Neurodevelopmental performance among pre-schoolers treated for severe anaemia at Lira Regional Referral Hospital, Uganda

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0240694
Author(s):  
Andrew S. Ssemata ◽  
Robert O. Opoka ◽  
John M. Ssenkusu ◽  
Noeline Nakasujja ◽  
Chandy C. John ◽  
...  
Keyword(s):  
Young Children ◽  
Severe Anaemia ◽  
Referral Hospital ◽  
Sub Saharan Africa ◽  
Motor Deficits ◽  
Community Control ◽  
Long Term Effects ◽  
Neurodevelopmental Outcomes ◽  
Regional Referral Hospital ◽  
Z Scores

Background Severe anaemia is a common clinical problem among young children in sub-Saharan Africa. However, the effect of severe anaemia on neurodevelopment of these children is not well described. Therefore, we assessed the neurodevelopmental performance of preschool children diagnosed with severe anaemia in Northern Uganda. Methods We conducted a prospective cohort study among children < 5 years of age 14 days post discharge after an episode of severe anaemia (Hb < 5.0 g/dl; n = 171; mean Hb = 3.9g/dl) at Lira Regional Referral Hospital, Uganda. Neurodevelopmental outcomes (cognitive, language and motor) were assessed using Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III). Age-adjusted z-scores for each domain were calculated using scores from healthy community control children (n = 88) recruited from the same environment for each age category. Multiple linear regression was used to compare z-scores in the cognitive, language and motor scales between the two groups after adjusting for weight-for-age z-score, socioeconomic status, mother’s education, and father’s employment on all the scales. Results The prevalence of neurodevelopmental impairment was 2.3% (95% CI: 0.8–6.1) for cognition, 1.7% (95%: 0.6–5.3) for language and 3.5% (95% CI: 1.6–7.6) for motor scales and 4.6% (95% CI: 2.3–9.1) for deficits in ≥1 area of neurodevelopment. Significant differences were observed between the two groups with the SA group performing worse on cognition [adjusted mean score, (Standard error, SE), P-value] [-0.20, (0.01) vs. 0.00, (0.01), P = 0.02]; language [-0.25, (0.01) vs. 0.00, (0.01), P< 0.001]; and motor [-0.17, (0.01) vs. 0.00, (0.01), P = 0.05] scales. Conclusion In children < 5 years of age, severe anaemia was associated with neurocognitive (cognition, language and motor) deficits in the immediate period post treatment. Further research is needed to identify risk factors and determine the long-term effects of poor neurodevelopment in young children with severe anaemia.

scholarly journals Hospitalization For Iron Deficiency Anemia In Young Children: A Multicenter Analysis

2021 ◽  
Author(s):  
Julia Segal ◽  
Molly Mack ◽  
Meghan McCormick ◽  
Ram Kalpatthi
Keyword(s):  
Iron Deficiency ◽  
Young Children ◽  
Iron Deficiency Anemia ◽  
Health Information System ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Blood Product Transfusion ◽  
Index Hospitalization ◽  
Neurodevelopmental Outcomes ◽  
Factors Associated

Background Iron deficiency anemia (IDA) is detrimental to growth and neurodevelopmental outcomes in young children. IDA is primarily managed in the outpatient setting, though children with severe anemia may require admission. No prior studies of children with severe IDA admitted to US children’s hospitals exist. The objective is to describe characteristics of children requiring admission for IDA. Procedure Using the Pediatric Health Information system database, we identified children age 0-5 years admitted from 2004-2018 with a primary diagnosis of IDA. Patient characteristics were compared by chi-square test or t-test of means. Univariate logistic regression was used to identify factors associated with readmission. We also performed a retrospective review of primary care records. Results A total of 4963 unique patients were identified, with 5202 unique hospitalizations. The mean age at admission at index hospitalization was 1.5 years with no gender difference. A trend towards an increasing number of admissions was noted in recent years. The majority of the patients received blood transfusions (87.3%) and oral iron (61.4%), whereas only 4.9% of patients received intravenous iron. Overall, 13.1% of patients required ICU admission, which was more common in female patients and children of Black or Asian race. Factors associated with decreased odds of readmission included blood product transfusion and use of oral iron during the index hospitalization. Conclusions IDA is a preventable condition, with potential for detrimental long-term outcomes. Trends in the number of admissions over time are concerning in light of the substantial use of hospital resources.

The Modification of Hypernasality in Young Children

1984 ◽  
Vol 15 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Moya L. Andrews ◽  
Sarah J. Tardy ◽  
Lisa G. Pasternak
Keyword(s):  
Young Children ◽  
Voice Therapy

This paper presents an approach to voice therapy programming for young children who are hypernasal. Some general principles underlying the approach are presented and discussed.

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