scholarly journals 474P Prognostic and predictive role of Consensus Molecular Subtypes (CMS) determined by immunohistochemistry in metastatic colorectal cancer (mCRC)

2020 ◽  
Vol 31 ◽  
pp. S442-S443
Author(s):  
O. Higuera Gomez ◽  
V. Heredia Soto ◽  
I. Machado ◽  
M.C. Mendez ◽  
M. Cuatrecasas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Molecular Subtypes ◽  
Predictive Role

scholarly journals Prognostic and predictive role of neutrophil/lymphocytes ratio in metastatic colorectal cancer: a retrospective analysis of the TRIBE study by GONO

2018 ◽  
Vol 29 (4) ◽  
pp. 924-930 ◽  
Author(s):  
E. Dell’Aquila ◽  
C. Cremolini ◽  
T. Zeppola ◽  
S. Lonardi ◽  
F. Bergamo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Retrospective Analysis ◽  
Predictive Role

The Predictive Role of ERCC1 Status in Oxaliplatin Based Neoadjuvant Therapy for Metastatic Colorectal Cancer (mCRC) to the Liver

2015 ◽  
Vol 33 (4) ◽  
pp. 89-97 ◽  
Author(s):  
Ravit Geva ◽  
Sivan Shamai ◽  
Eli Brazowsky ◽  
Michael Paoulas ◽  
Mendi Ben-Haim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Neoadjuvant Therapy ◽  
Predictive Role

Prognostic and Predictive Role of CXC Chemokine Receptor 4 in Metastatic Colorectal Cancer Patients

2020 ◽  
Vol 28 (10) ◽  
pp. 755-760 ◽  
Author(s):  
Alessandro Ottaiano ◽  
Stefania Scala ◽  
Nicola Normanno ◽  
Gerardo Botti ◽  
Fabiana Tatangelo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Chemokine Receptor ◽  
Cxc Chemokine Receptor 4 ◽  
Cxc Chemokine ◽  
Predictive Role ◽  
Colorectal Cancer Patients ◽  
Chemokine Receptor 4

The Predictive Role of Primary Tumour Sidedness in Metastatic Colorectal Cancer Treated With Targeted Agents

2019 ◽  
Vol 39 (10) ◽  
pp. 5645-5652
Author(s):  
ONDREJ FIALA ◽  
PAVEL OSTASOV ◽  
PETR HOSEK ◽  
ONDREJ SOREJS ◽  
VACLAV LISKA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Primary Tumour ◽  
Targeted Agents ◽  
Predictive Role

Association of a polymorphism in amphiregulin with worse prognosis in metastatic colorectal cancer patients treated with cetuximab.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e14543-e14543
Author(s):  
Peter M. D. Wilson ◽  
Takeru Wakatsuki ◽  
Fotios Loupakis ◽  
Wu Zhang ◽  
Dongyun Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Progression Free Survival ◽  
Direct Dna Sequencing ◽  
Predictive Role ◽  
Third Line ◽  
Colorectal Cancer Patients ◽  
Gene Expression Levels

e14543 Background: Accumulating data suggests that Amphiregulin (AREG) and Epiregulin (EREG), ligands of the EGFR pathway, are potential prognostic and predictive markers in metastatic colorectal cancer (mCRC). Elevated AREG and EREG gene expression levels are predictive of improved response rates in mCRC patients treated with cetuximab and longer overall survival (OS) in patients with mCRC who did not receive cetuximab. Since polymorphisms in AREG and EREG may affect their expression or function, we tested whether AREG and EREG polymorphisms were associated with clinical outcome in mCRC patients treated with cetuximab. Methods: Seventy-three patients (n=73) with histopathologically-confirmed mCRC with Kras/Braf wild type were enrolled in Italy. These patients were treated with cetuximab monotherapy or irinotecan plus cetuximab as second or third line treatment. Genomic DNA was extracted from blood and 4 SNPs in AREG and 5 SNPs in EREG were analyzed by direct DNA-sequencing. Results: The median follow-up period was 13.3 months in this cohort. The median progression-free survival (PFS) and OS were 5.2 and 12.9 months respectively. The results indicate that the intronic AREG polymorphism rs28364983 A/C was associated with shorter PFS and OS. Patients with homozygous C/C (n=2) showed a median PFS of 2.3 months vs. 5.3 months for patients harboring at least one-A allele (n=71) (HR: 4.26 [95%CI: 0.98-18.5], p=0.05). Patients with homozygous C/C showed a median OS of 3.0 months vs. 13.1 months for patients harboring at least one-A allele (HR: 3.98 [95%CI: 0.93-16.9], p=0.062). An independent cohort of thirty-three patients was used to validate these initial findings and showed that patients with homozygous C/C (n=3) had a median PFS of 2.3 months vs. 3.8 months for patients harboring at least one-A allele (n=103) (HR: 3.79 [95%CI: 1.16-12.3], p=0.027) and a median OS of 3.0 months vs. 8.4 months (HR: 3.01 [95%CI: 0.93-9.71], p=0.065), respectively. Conclusions: AREG rs28364983 predicted worse outcome in mCRC patients treated with cetuximab; however, further analyses are necessary to understand the mechanism and further validate the prognostic and/or predictive role of this polymorphism.

scholarly journals Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study

2012 ◽  
Vol 10 (1) ◽  
pp. 87 ◽  
Author(s):  
Paola Ulivi ◽  
Laura Capelli ◽  
Martina Valgiusti ◽  
Wainer Zoli ◽  
Emanuela Scarpi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Single Center ◽  
Multiple Gene ◽  
Single Center Study ◽  
Predictive Role ◽  
Gene Alterations ◽  
Center Study

scholarly journals Prognostic and predictive role of body mass index (BMI) in metastatic colorectal cancer (mCRC): A pooled analisys of TRIBE and TRIBE-2 studies by GONO

2019 ◽  
Vol 30 ◽  
pp. v218-v219
Author(s):  
E. Dell’Aquila ◽  
D. Rossini ◽  
M. Stellato ◽  
F. Bergamo ◽  
G. Aprile ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Metastatic Colorectal Cancer ◽  
Body Mass ◽  
Predictive Role

WITHDRAWN: Predictive role of body composition on survival and treatment toxicity in metastatic colorectal cancer patients

2017 ◽  
Vol 31 (2) ◽  
pp. 162
Author(s):  
C. Vandeputte ◽  
J. Krygier ◽  
L. Ameye ◽  
A. Hendlisz ◽  
N. Charette
Keyword(s):  
Colorectal Cancer ◽  
Body Composition ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Treatment Toxicity ◽  
Predictive Role ◽  
Colorectal Cancer Patients

scholarly journals Prognostic and predictive role of neutrophils/lymphocytes ratio in metastatic colorectal cancer: A retrospective analysis of the TRIBE study by Gono

2017 ◽  
Vol 28 ◽  
pp. iii141-iii142
Author(s):  
Emanuela Dell' Aquila ◽  
Chiara Cremolini ◽  
Tea Zeppola ◽  
Sara Lonardi ◽  
Francesca Bergamo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Retrospective Analysis ◽  
Predictive Role

Prognostic and predictive role of circulating eNOS and EPHB4 in metastatic colorectal cancer patients receiving bevacizumab.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e23083-e23083 ◽  
Author(s):  
Giorgia Marisi ◽  
Emanuela Scarpi ◽  
Alessandro Passardi ◽  
Oriana Nanni ◽  
Angela Ragazzini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Predictive Role ◽  
Colorectal Cancer Patients
Sign in / Sign up

Export Citation Format

Share Document