P-58 CONCORDANCE BETWEEN ECOGRAPHY AND THE CONTINUOUS ATTENUATION PARAMETER (CAP) BY TRANSIENT ELASTOGRAPHY FOR THE DIAGNOSIS OF LIVER STEATOSIS

Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP) is used as a non-invasive method for evaluating liver steatosis and fibrosis simultaneously. In this prospective study, we aimed to assess the prevalence of liver steatosis and fibrosis, as well as the associated risk factors in Romanian medical students by VCTE and CAP score. We used a cut-off CAP score of ≥248 dB/m for the diagnosis of mild steatosis (S1), ≥268 dB/m for moderate steatosis (S2), and ≥280 dB/m to identify severe steatosis (S3). For liver fibrosis, the cut-off values were: ≤5.5 kPa, indicating no fibrosis (F0), 5.6 kPa for mild fibrosis (F1), 7.2 kPa for significant fibrosis (F2), 9.5 kPa for advanced fibrosis (F3), and 12.5 kPa for cirrhosis (F4). In total, 426 Romanian medical students (67.8% females, mean age of 22.22 ± 1.7 years) were evaluated. Among them, 352 (82.6%) had no steatosis (S0), 32 (7.5%) had mild steatosis (S1), 13 (3.1%) had a moderate degree of steatosis (S2), and 29 (6.8%) had severe steatosis (S3). Based on liver stiffness measurements (LSM), 277 (65%) medical students did not have any fibrosis (F0), 136 (31.9%) had mild fibrosis (F1), 10 (2.4%) participants were identified with significant fibrosis (F2), 3 (0.7%) with advanced fibrosis (F3), and none with cirrhosis (F4). In conclusion, the prevalence of liver steatosis and fibrosis is low among Romanian medical students.

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Changes in liver steatosis evaluated by transient elastography with the controlled attenuation parameter in HIV-infected patients

HIV Medicine ◽

10.1111/hiv.12384 ◽

2016 ◽

Vol 17 (10) ◽

pp. 766-773 ◽

Cited By ~ 17

Author(s):

J Macías ◽

LM Real ◽

A Rivero-Juárez ◽

N Merchante ◽

A Camacho ◽

...

Keyword(s):

Transient Elastography ◽

Liver Steatosis ◽

Controlled Attenuation Parameter ◽

Attenuation Parameter

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Vibration-Controlled Transient Elastography and Controlled Attenuation Parameter for the Diagnosis of Liver Steatosis and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

Diagnostics ◽

10.3390/diagnostics11050787 ◽

2021 ◽

Vol 11 (5) ◽

pp. 787

Author(s):

Sebastian Zenovia ◽

Carol Stanciu ◽

Catalin Sfarti ◽

Ana-Maria Singeap ◽

Camelia Cojocariu ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Hepatic Steatosis ◽

Fatty Liver Disease ◽

Transient Elastography ◽

Liver Steatosis ◽

Controlled Attenuation Parameter ◽

Nonalcoholic Fatty Liver ◽

Attenuation Parameter

Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP) is a widely used non-invasive technique for concomitant assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the level both of hepatic steatosis and fibrosis as well as the associated risk factors in patients referred to our unit with clinically suspected NAFLD or diagnosed by abdominal ultrasonography. Two hundred four patients were prospectively included in this study and assessed by VCTE with CAP. The final analysis included 181 patients with reliable liver stiffness measurements (LSMs) (53% female, mean age 57.62 ± 11.8 years and BMI 29.48 ± 4.85 kg/m2). According to the cut-off values for steatosis grading, there were 10 (5.5%) patients without steatosis (S0), 30 (16.6%) with mild (S1), 45 (24.9%) moderate (S2), and 96 (53%) severe (S3) steatosis. Based on LSM, there were 73 (40.3%) patients without fibrosis (F0), 42 (23.2%) with mild (F1), 32 (17.7%) significant (F2), 19 (10.5%) advanced (F3) fibrosis, and 15 (8.3%) with cirrhosis (F4). In addition, we found an association between several metabolic components and hepatic steatosis and fibrosis. Thus, in the multivariate analysis, higher BMI, fasting plasma glucose, triglycerides, low-density lipoprotein cholesterol, and serum uric were associated with increased CAP. Furthermore, higher serum uric acid and alpha-fetoprotein together with lower platelets count and albumin levels were associated with increased LSM. The assessment of steatosis and fibrosis using VCTE and CAP should be performed in all patients with suspected or previously diagnosed NAFLD in units with available facilities.

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Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg

Russian Journal of Gastroenterology Hepatology Coloproctology ◽

10.22416/1382-4376-2021-31-1-31-38 ◽

2021 ◽

Vol 31 (1) ◽

pp. 31-38

Author(s):

V. P. Kovyazina ◽

K. L. Raikhelson ◽

M. K. Prashnova ◽

E. V. Pazenko ◽

L. K. Palgova ◽

...

Keyword(s):

Structural Changes ◽

Transient Elastography ◽

Liver Steatosis ◽

Laboratory Data ◽

Controlled Attenuation Parameter ◽

Non Invasive ◽

Attenuation Parameter ◽

High Incidence ◽

Liver Changes ◽

High Degree

Aim. Estimation of the liver steatosis and fibrosis incidence with transient elastography and the controlled attenuation parameter in residents of St. Petersburg.Materials and methods. A prospective open single-centre population study included history, anthropometric and laboratory data on 318 outpatients aged 24—89 years (mean age 52.6 ± 14.6 years). The degrees of steatosis (assessed with the controlled attenuation parameter as ultrasound amplitude dropdown quantification in liver) and fibrosis were determined with a Fibroscan 502 Touch unit (Echosens, France).Results. Hepatic steatosis of predominantly high degree was revealed in 44.7%, combined fibrosis and steatosis — in 28%; isolated fibrosis of various stage — in 2.5%, no structural changes — in 24.8% individuals. The growth of body mass index and waist circumference significantly correlated in women with pronounced liver changes. Serum transaminase activity increased with more severe liver changes, being statistically significant for aspartic transaminase only.Conclusion. A high incidence of primary liver steatosis and fibrosis in residents of St. Petersburg warrants improved diagnostic algorithms and routine preventive measures. Transient elastography with the controlled attenuation parameter estimation provides a convenient non-invasive screening for hepatic fibrosis and steatosis.

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Diagnostic Accuracy of Controlled Attenuation Parameter Measured by Transient Elastography for the Non-invasive Assessment of Liver Steatosis: a Prospective Study

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.mlp ◽

2015 ◽

Vol 24 (1) ◽

pp. 35-42 ◽

Cited By ~ 20

Author(s):

Monica Lupșor-Platon ◽

Diana Feier ◽

Horia Stefănescu ◽

Attila Tamas ◽

Emil Botan ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Multivariate Regression ◽

Transient Elastography ◽

Liver Steatosis ◽

Chronic Liver Diseases ◽

Controlled Attenuation Parameter ◽

Non Invasive ◽

Attenuation Parameter ◽

Ultrasound Attenuation ◽

A Prospective Study

Background & Aims: A novel non-invasive tool based on the evaluation of ultrasound attenuation using transient elastography (TE) has been developed, called controlled attenuation parameter (CAP). We aim to establish the histopathological parameters that significantly influence CAP, the cutoff values and their performance in predicting each steatosis grade on a group of biopsied patients with chronic liver diseases (CLD) from Romania.Methods. We prospectively analyzed 201 consecutive CLD patients who underwent CAP measurements using TE. Steatosis, liver fibrosis and necroinflammatory activity were staged and graded during the pathological analysis of bioptic specimens. Univariate and multivariate regression analyses were applied to identify the variables correlated with CAP values. The diagnostic performance of CAP for steatosis prediction was assessed using an AUC analysis.Results. Among the histopathological factors correlating with CAP, the multivariate analysis found steatosis as the only factor independently influencing CAP values (p<0.001). Maximal diagnostic accuracy (DA) was obtained for the prediction of ≥34-66% (S2) fatty load and of 67-100% (S3) fatty load (82.06%, respectively 81.59%) while, for the prediction of ≥11-33% (S1) fatty load, DA reached only 76.11%. The negative predictive value for the exclusion of ≥S2 and S3 was 93.5% and 98.7%, respectively. AUCs calculated between each two steatosis grades were: 0.772 (S0 vs S1), 0.874 (S0 vs S2), 0.904 (S0 vs S3), 0.659 (S1vs S2), 0.777 (S1 vs S3), and 0.665 (S2 vs S3).Conclusion. Steatosis is the only histopathological factor independently influencing CAP. Maximal DA could be obtained for the prediction of ≥S2 and S3 (82.06% and 81.59%), while for the prediction of S1, the accuracy reached only 76.11%.

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Transient elastography (FibroScan®) with controlled attenuation parameter in the assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease - Where do we stand?

World Journal of Gastroenterology ◽

10.3748/wjg.v22.i32.7236 ◽

2016 ◽

Vol 22 (32) ◽

pp. 7236 ◽

Cited By ~ 77

Author(s):

Ivana Mikolasevic ◽

Lidija Orlic ◽

Neven Franjic ◽

Goran Hauser ◽

Davor Stimac ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Transient Elastography ◽

Liver Steatosis ◽

Controlled Attenuation Parameter ◽

Nonalcoholic Fatty Liver ◽

Attenuation Parameter

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Prevalence and factors associated with liver steatosis as measured by transient elastography with controlled attenuation parameter in HIV-infected patients

AIDS ◽

10.1097/qad.0000000000000248 ◽

2014 ◽

Vol 28 (9) ◽

pp. 1279-1287 ◽

Cited By ~ 39

Author(s):

Juan Macías ◽

Juan González ◽

Cristina Tural ◽

Enrique Ortega-González ◽

Federico Pulido ◽

...

Keyword(s):

Transient Elastography ◽

Liver Steatosis ◽

Controlled Attenuation Parameter ◽

Factors Associated ◽

Attenuation Parameter

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Non-invasive Assessment of Liver Steatosis and Fibrosis Using Transient Elastography and Controlled Attenuation Parameter in type 2 Diabetes Patients

Acta Endocrinologica (Bucharest) ◽

10.4183/aeb.2018.394 ◽

2018 ◽

Vol 14 (3) ◽

pp. 394-400

Author(s):

A Sima

Keyword(s):

Type 2 Diabetes ◽

Transient Elastography ◽

Liver Steatosis ◽

Controlled Attenuation Parameter ◽

Non Invasive ◽

Attenuation Parameter ◽

Diabetes Patients

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Correlation of Hepatic Steatosis with Hepatic Fibrosis in NAFLD Patients by Fibroscan

Asian Journal of Medical Research ◽

10.47009/ajmr.2020.9.3.me1 ◽

2020 ◽

Vol 9 (3) ◽

pp. 1-7

Author(s):

Rishabh Sehgal ◽

Jyotisterna Mittal ◽

Inderpal Singh

Keyword(s):

Hepatic Steatosis ◽

Hepatic Fibrosis ◽

Transient Elastography ◽

Liver Steatosis ◽

Liver Stiffness ◽

Controlled Attenuation Parameter ◽

Nonalcoholic Fatty Liver ◽

Attenuation Parameter ◽

History Of ◽

The Mean

Introduction: Nonalcoholic fatty liver disease (NAFLD) is a significant cause of liver injury in the world. Transient elastography with controlled attenuation parameter (CAP) is now days commonly used as a non-invasive modality to quantify liver steatosis and stage of Fibrosis in the Liver. This study was done to the correlation of hepatic Steatosis with hepatic Fibrosis in NAFLD Patients by fibroscan. Subjects and Methods: All NAFLD patients coming to DMCH from 1/1/18 to 30/11/18 were retrospectively analysed for the presence of any correlation between Steatosis and Fibrosis using a controlled attenuation parameter (CAP) and liver stiffness measurement (kPa), respectively by Fibroscan. Patients with a history of significant alcohol intake, viral infection, severe weight loss, on TPN, on drugs like amiodarone, diltiazem, steroids were excluded. Along with this history of hypertension, diabetes and smoking were noted from the available data. Results: The mean CAP of all 446 patients was 310.58 53.55 and the mean kPa was 7.14 4.75. Overall there was a significant correlation between CAP and kPa in all NAFLD patients (p <0.000). This was also true in patients who were more than 20 years of age, who have increased levels of triglycerides and were obese. Patients with S0 steatosis had a mean kPa value of 5.33 and as the steatosis stage worsened to S3 mean kPa value also increased to a maximum of 7.63. Conclusion: Quantification of Steatosis by CAP has a significant correlation with the stage of Fibrosis, especially in patients with increasing age, obese and who have high triglyceride levels.

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