Nine subjects performed a visual search task for two 100-minute sessions using microfiche with positive appearing images and small, portable microfiche readers. During one session the subjects performed the task with a reader having a screen with highly visible scintillation. During the other they used a reader equipped with a screen that was nearly free from scintillation. Dependent variables were subjective visual fatigue, general fatigue, and number of targets located. Subjects reported significantly greater visual fatigue after viewing the “high” scintillation screen for 50–100 minutes than after viewing the “low” scintillation screen for the same length of time. When the high-scintillation screen was used, the subjects also reported an increase in general fatigue. Screen scintillation did not affect the subjects' performance on the search task, however.