Poster 255 Microarray study of gene expression profile after acute spinal cord injury Leslie R. Morse DO (Boston Med Ctr, Boston, MA); Ricardo A. Battaglino PhD; Martha Joe; David Meguerdichian; Hajime Sasaki DDS, PhD; Steve Williams MD, [email protected]

2004 ◽  
Vol 85 (9) ◽  
pp. e51
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Acute Spinal Cord Injury ◽  
Microarray Study ◽  
Cord Injury

scholarly journals Bioinformatic analysis of the gene expression profile in muscle atrophy after spinal cord injury

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hui Huang ◽  
Jinju Xue ◽  
Jiaxuan Zheng ◽  
Haiquan Tian ◽  
Yehan Fang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Network Analysis ◽  
Gene Expression Profile ◽  
Muscle Atrophy ◽  
Expression Profile ◽  
Pathway Network ◽  
Cord Injury ◽  
Signal Network

AbstractSpinal cord injury (SCI) is often accompanied by muscle atrophy; however, its underlying mechanisms remain unclear. Here, the molecular mechanisms of muscle atrophy following SCI were investigated. The GSE45550 gene expression profile of control (before SCI) and experimental (14 days following SCI) groups, consisting of Sprague–Dawley rat soleus muscle (n = 6 per group), was downloaded from the Gene Expression Omnibus database, and then differentially expressed gene (DEG) identification and Gene Ontology, pathway, pathway network, and gene signal network analyses were performed. A total of 925 differentially expressed genes, 149 biological processes, and 55 pathways were screened. In the pathway network analysis, the 10 most important pathways were citrate cycle (TCA cycle), pyruvate metabolism, MAPK signalling pathway, fatty acid degradation, propanoate metabolism, apoptosis, focal adhesion, synthesis and degradation of ketone bodies, Wnt signalling, and cancer pathways. In the gene signal network analysis, the 10 most important genes were Acat1, Acadvl, Acaa2, Hadhb, Acss1, Oxct1, Hadha, Hadh, Acaca, and Cpt1b. Thus, we screened the key genes and pathways that may be involved in muscle atrophy after SCI and provided support for finding valuable markers for this disease.

Identifying gene expression profile of spinal cord injury in rat by bioinformatics strategy

2014 ◽  
Vol 41 (5) ◽  
pp. 3169-3177 ◽  
Author(s):  
Lingjing Jin ◽  
Zhourui Wu ◽  
Wei Xu ◽  
Xiao Hu ◽  
Jin Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Cord Injury

scholarly journals Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord Injury

2019 ◽  
Vol 36 (3) ◽  
pp. 411-420 ◽  
Author(s):  
Tsutomu Oshigiri ◽  
Toru Sasaki ◽  
Masanori Sasaki ◽  
Yuko Kataoka-Sasaki ◽  
Masahito Nakazaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Motor Cortex ◽  
Rat Model ◽  
Intravenous Infusion ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss

2001 ◽  
Vol 7 (2) ◽  
pp. 201-213 ◽  
Author(s):  
JASON B. CARMEL ◽  
ANTHONY GALANTE ◽  
PATRICIA SOTEROPOULOS ◽  
PETER TOLIAS ◽  
MICHAEL RECCE ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Large Scale ◽  
Acute Spinal Cord Injury ◽  
Mrna Levels ◽  
Injury Site ◽  
Phosphodiesterase 4 ◽  
Cord Injury ◽  
Specific Mrnas

We have completed the first large-scale gene expression study of acute spinal cord injury (SCI) in rat. Oligonucleotide microarrays containing 1,200 gene-specific probes were used to quantify mRNA levels, relative to uninjured controls, in spinal cords injured using a standard contusion model. Our results revealed a marked loss of neuron-specific mRNAs at the injury site. The surviving cells showed a characteristic inflammatory response that started at the injury site and spread to the distal cord. Changes in several mRNA levels were associated with putative regenerative responses in the spinal cord. Notably, phosphodiesterase 4, nestin, glia-derived neurite promoting factor, and GAP-43 mRNAs increased significantly. Other mRNAs clustered temporally and spatially with these regeneration-associated genes. Thus we have described global patterns of gene expression following acute SCI, and we have identified targets for future study and possible therapeutic intervention.

scholarly journals Quantitative assessment of gene expression following acute spinal cord injury

2008 ◽  
Vol 81 ◽  
pp. 106-107
Author(s):  
J. N. Earnhardt ◽  
B. McCray ◽  
M. Dobrzeniecka ◽  
B. E. Keeler ◽  
A. V. C. Tabernilla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Quantitative Assessment ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

233-LB: Spinal Cord Injury Inhibited-FGF21 Signaling Is Associated with Dysregulation of Metabolic Gene Expression in Mouse Liver and Adipose Tissue

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 233-LB
Author(s):  
XIN-HUA LIU ◽  
LAUREN HARLOW ◽  
ZACHARY GRAHAM ◽  
JOSHUA F. YARROW ◽  
KENNETH CUSI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Mouse Liver ◽  
Metabolic Gene ◽  
Metabolic Gene Expression ◽  
Cord Injury

Vasopressor support in managing acute spinal cord injury: current knowledge

2019 ◽  
Vol 63 (3) ◽  
Author(s):  
John K. Yue ◽  
Rachel E. Tsolinas ◽  
John F. Burke ◽  
Hansen Deng ◽  
Pavan S. Upadhyayula ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Current Knowledge ◽  
Acute Spinal Cord Injury ◽  
Vasopressor Support ◽  
Cord Injury
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