Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells

2015 ◽  
Vol 106 ◽  
pp. 213-219 ◽  
Author(s):  
Akira Sato ◽  
Tasuku Itoh ◽  
Shoji Imamichi ◽  
Sota Kikuhara ◽  
Hiroaki Fujimori ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neutron Capture ◽  
Proteomic Analysis ◽  
Cellular Response ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Human Squamous Cell Carcinoma ◽  
Boron Neutron Capture

scholarly journals Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Ying Sun
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Locally Recurrent ◽  
Recurrent Head

Abstract Locally recurrent head and neck squamous cell carcinoma (HNSCC) is often unresectable, and a repeat course of radiotherapy is associated with incremental toxicities. Boron neutron capture therapy (BNCT) is a novel targeted radiotherapy modality that can achieve a high dose gradient between cancerous and adjacent normal tissues. However, the relationships among the dose resulting from BNCT, tumor response to BNCT, and survival are not completely understood. Recently, a study published in Radiotherapy and Oncology investigated the efficacy of BNCT in the treatment of patients with locally recurrent HNSCC and the factors associated with favorable treatment response and survival. In this article, the findings, strengths and limitations of this study are discussed in depth, and the significance of the study and motivations for future research are highlighted.

Effect of neutron capture therapy on the cell cycle of human squamous cell carcinoma cells

2008 ◽  
Vol 84 (3) ◽  
pp. 191-199 ◽  
Author(s):  
Akitoshi Kamida ◽  
Yusei Fujita ◽  
Itsuro Kato ◽  
Soichi Iwai ◽  
Koji Ono ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neutron Capture ◽  
Carcinoma Cells ◽  
Neutron Capture Therapy ◽  
Human Squamous Cell Carcinoma

Boron neutron capture therapy (BNCT) for the treatment of spontaneous nasal planum squamous cell carcinoma in felines

2007 ◽  
Vol 47 (1) ◽  
pp. 147-155 ◽  
Author(s):  
Verónica A. Trivillin ◽  
Elisa M. Heber ◽  
Monica Rao ◽  
María A. Cantarelli ◽  
Maria E. Itoiz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals Boron Neutron Capture Therapy for Squamous Cell Carcinoma of the Skull Base

2012 ◽  
Vol 147 (2_suppl) ◽  
pp. P148-P148
Author(s):  
Takaki Inui ◽  
Shin-Ichi Haginomori ◽  
Takahiro Ichihara ◽  
Atsuko Takamaki ◽  
Ryo Kawata
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Skull Base ◽  
Squamous Cell ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

Characterization of the Eugenol Effects on the Bioenergetic Profile of SCC-4 Human Squamous Cell Carcinoma Cell Line

2018 ◽  
Vol 69 (9) ◽  
pp. 2567-2570 ◽  
Author(s):  
Oana M. Duicu ◽  
Ioana Z. Pavel ◽  
Florin Borcan ◽  
Danina M. Muntean ◽  
Adelina Cheveresan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Squamous Cell Carcinoma Cell ◽  
Human Squamous Cell Carcinoma ◽  
Extracellular Flux ◽  
Transport Chain

Eugenol (EU), the active ingredient in clove oil, is commonly used as successful therapeutic compound in dentistry due to its antiseptic and anti-inflammatory effects. Recent research studies suggest that eugenol has also a potential anti-cancer effect. This study was thereby purported to assess the effects of EU on the bioenergetic profile of the SCC-4 human squamous cell carcinoma cell line. To this aim, SCC-4 cells were treated for 24 hours with free EU and EU incorporated in polyurethane structures (50 �M each). Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were measured using the Seahorse XF-24e extracellular flux analyzer (Agilent Technologies Inc.). Analysis of the SCC-4 bioenergetic profile was performed in the presence of the classic modulators of the electron transport chain: oligomycin, FCCP, and antimycin A+rotenone. Our data showed that cells stimulated with free EU induced a decrease of OCR linked parameters and an increase of ECAR, effects that were abolished by the incorporation of EU in polyurethane structures. In conclusion, free eugenol elicits inhibitory effects on mitochondrial respiration in the SCC-4 cell line, a result that might be suggestive for its anti-tumoral effects.

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