The concept of minimum detectable activity of radionuclide activity meters and their suitability for routine quality control of radiopharmaceuticals. An experimental study

2016 ◽  
Vol 113 ◽  
pp. 22-27 ◽  
Author(s):  
F. Zagni ◽  
F. Cesarini ◽  
G. Lucconi ◽  
G. Cicoria ◽  
D. Pancaldi ◽  
...  
Keyword(s):  
Experimental Study ◽  
Quality Control ◽  
Minimum Detectable Activity ◽  
Detectable Activity ◽  
Routine Quality Control ◽  
Radionuclide Activity

Experimental determination of minimum detectable activity for radionuclide activity meters

2014 ◽  
Vol 30 ◽  
pp. e29-e30
Author(s):  
F. Zagni ◽  
F. Cesarini ◽  
G. Lucconi ◽  
G. Cicoria ◽  
D. Pancaldi ◽  
...  
Keyword(s):  
Experimental Determination ◽  
Minimum Detectable Activity ◽  
Detectable Activity ◽  
Radionuclide Activity

UV spectroscopic method for determination of phenytoin in bulk and injection forms

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Spectroscopic Method ◽  
Ich Guidelines ◽  
Precision And Accuracy ◽  
Routine Quality Control

Recent study was conducted to develop a simple UV spectrophotometric method to determine Phenytoin in bulk and injection form according to official requirement and validate as per ICH guidelines. λmax of Phenytoin was found 202 nm. Linearity existed perceived in the concentration assortment 2-8 μg/ml (r2 = 0.999) for the method. The method was validated pertaining to linearity, precision and accuracy studies, LOD and LOQ consistent with ICH guidelines. The existent method was establish to be simple, linear, precise, accurate as well as sensitive and can be applied for routine quality control enquiry for the analysis of Phenytoin in bulk and injection form.

scholarly journals Absence of Detectable Radionuclides in Breast Milk in Sendai, Japan in 2012 Even by High-Sensitivity Determination: Estimated Dose among Infants after the Fukushima Nuclear Disaster

2021 ◽  
Vol 18 (11) ◽  
pp. 5825
Author(s):  
Zhaoqing Lyu ◽  
Sani Rachman Soleman ◽  
Tomoko Fujitani ◽  
Yukiko Fujii ◽  
Manal A. M. Mahmoud ◽  
...  
Keyword(s):  
Breast Milk ◽  
High Sensitivity ◽  
Minimum Detectable Activity ◽  
Activity Level ◽  
Internal Exposure ◽  
Dietary Intakes ◽  
Detectable Activity ◽  
Nuclear Disaster ◽  
Exposure Limit ◽  
Fukushima Nuclear Disaster

The aim of this study was to estimate radionuclide levels in breast milk and the transferred dose to their infants in Sendai (100 km from Fukushima), Japan after the 2011 Fukushima nuclear disaster. Radionuclide concentrations were analyzed in 101 specimens of breast milk collected in 2012. Median values for minimum detectable activities were 0.39, 0.34, 1.1, 1.89, and 17.1 Bq/kg for 137Cs, 134Cs, 131I, 110mAg, and 40K, respectively. Only radionuclides from 40K were detected. To estimate potential exposure and radiocesium dose, we assumed that the samples contained each minimum detectable activity level. The mean minimum detectable activity concentrations (standard deviation) of 137Cs and 134Cs were 0.42 (0.15) and 0.37 (0.14) Bq/kg, respectively. Means of estimated dietary intakes of 137Cs and 134Cs among infants were 0.35 (0.12) and 0.31 (0.11) Bq/day, respectively. The committed effective doses of radiocesium in infants aged 3 and 12 months via breastmilk were estimated at 5.6 (2.1) and 3.3 (1.2) μSv/year, respectively. Dietary intakes of 137Cs and 134Cs in breastfeeding mothers were back-calculated at 1.9 (0.71) and 1.7 (0.65) Bq/day, respectively. The study verified no discernible exposure to radionuclides among infants. The most conservative estimates were below the Japanese internal exposure limit of 1 mSv/year.

DEVELOPMENT OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN AND ORNIDAZOLE IN COMBINED DOSAGE FORM

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (05) ◽  
pp. 36-43
Author(s):  
N. R Dighade ◽  
◽  
M. D Shende ◽  
A. V Kasture
Keyword(s):  
Quality Control ◽  
High Resolution ◽  
Thin Layer ◽  
Mobile Phase ◽  
High Performance ◽  
Dosage Form ◽  
Simultaneous Estimation ◽  
Ich Guidelines ◽  
Hptlc Method ◽  
Routine Quality Control

A simple and accurate high performance thin layer chromatographic (HPLTC) method has been developed and validated as per ICH guidelines for estimations of Ciprofloxacin (CP) and Ornidazole (ORN) in combined dosage form. The mobile phase was acetonitrile: toluene: water and triethylamine (5.5:1.8:1.5:1.6 V/V) was found to be best which gave high resolution with Rf 0.16 and 0.84 for ciprofloxacin and ornidazole respectively. The linearity of ciprofloxacin and ornidazole was found to be in the range of 0.4 to 0.8 µg/mL and 0.4 to 0.8 µg/mL, respectively. The coefficient of correlation (r2 ) was found to be greater than 0.989 for both the components by this method. The tablet analyses result (n = 5) were found to be > 100.84 % by HPTLC for both the components. The proposed method was found to be simple, accurate and suitable for routine quality control of marketed formulations containing these drugs.

scholarly journals Minimum Detectable Activity of Pb-210 in Skull From In vivo Measurements: Insights From the Literature

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiangpeng Meng ◽  
Yuanyuan Liu ◽  
Bin Wu ◽  
Jianping Cheng ◽  
Li Wang ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Minimum Detectable Activity ◽  
Active Area ◽  
Semiconductor Detectors ◽  
Background Count ◽  
Radon Exposure ◽  
Detectable Activity ◽  
Retrospective Assessment ◽  
History Of

To address the urgent need for the retrospective assessment of the health conditions of people with a history of appreciable radon exposure, a novel technique that directly measures the characteristic γ-rays emitted from Pb-210 in the living skull was developed. Since the first pioneering study in 1968, this technique has experienced continued advancement over more than half a century, where the limit of detection of Pb-210 is a common criterion to assess the performance of the measuring devices. However, researchers have defined the limit of detection in assorted ways, and the measurement conditions often greatly differ from study to study, both of which significantly challenge interstudy comparisons and obscure how various factors make their impacts. In this work, we reanalyze the reported results in the literature according to the minimum detectable activity (MDA) defined by Currie and investigate the effects of key elements therein. Firstly, we focus on the reported background count rates and analyze their dependence on detector’s energy resolution and active area. Secondly, we turn to the reported calibration factors and conduct analysis in the same manner. Thirdly, we calculate MDA for each study and monitor its dependence on the active area of detector and measurement duration. In the limit of the largest achievable active area (∼75000 mm2), it is found that the asymptotic MDA is approximately 6 (4) Bq and 15 (11) Bq under 30 (60) min measurement using NaI-CsI scintillator and HPGe semiconductor detectors, respectively. Finally, we discuss these asymptotic MDA in the context of estimated Pb-210 activity in the skull resulted from a hypothetical history of radon exposure.

scholarly journals Análisis inmunofenotípico de muestras normales de médula ósea: aplicaciones en el control de calidad en los laboratorios de citometría

2010 ◽  
Vol 15 (3) ◽  
pp. 206 ◽  
Author(s):  
Diana Carolina Roa-Higuera ◽  
Susana Fiorentino-Gómez ◽  
Viviana Marcela Rodríguez-Pardo ◽  
Alba Myriam Campos-Arenas ◽  
Elvira Antonia Infante-Acosta ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Quality Control ◽  
Reference Values ◽  
Cell Populations ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Cell Subpopulations ◽  
Hematologic Neoplasia ◽  
Routine Quality Control ◽  
Normal Leukocyte

<p><strong></strong><strong>Objective.</strong> To describe a standardized flow cytometry protocol for the relative and absolute quantification of hematopoietic cell subpopulations from normal bone marrow, and to evaluate the expression of different lineage-specific cell markers with a reactivity associated to cell differentiation to be used as part of the routine quality control in cytometry laboratories. <strong>Materials and methods. </strong>The immunophenotypical analysis of different cell subpopulations was done with samples from normal bone marrow using a panel of monoclonal and polyclonal antibodies useful in the characterization of acute leukemias with four different fluorescences, by means of a protocol that combines cell labeling of membrane and cytoplasm antigens. Expression analysis was done in terms of mean fluorescence intensity (MFI). Fluorescent beads at a known concentration were added for calculating the absolute count of cells.  <strong>Results.</strong> The antibody panel used allowed the identification and quantification of different normal leukocyte subpopulations of lymphatic and myeloid origin, including CD34+ stem cells and more differentiated cell populations in the granulocytic, monocytic, and erythroid cell lines. We established reference values for cell populations and cell marker expression ranges as part of routine quality control of cytometry laboratories. <strong>Conclusion.</strong> Immunophenotypic patterns identified as well as absolute and relative reference values for the different normal leukocyte populations from bone marrow can be used by cytometry laboratories as a basis for establishing reference parameters in phenotypic analyses of hematologic neoplasia.<strong> </strong></p> <p><strong>Key words: </strong>multiparametric flow cytometry, immunophenotype, hematologic neoplasia, normal bone marrow, reference values, quality control.</p>

scholarly journals Factors Affecting the Minimum Detectable Activity of Radioactive Noble Gases

2018 ◽  
Vol 16 (3) ◽  
pp. 301-308
Author(s):  
Ji-young Park ◽  
Young Gun Ko ◽  
Hyuncheol Kim ◽  
Jong-Myoung Lim ◽  
Wanno Lee
Keyword(s):  
Noble Gases ◽  
Minimum Detectable Activity ◽  
Factors Affecting ◽  
Detectable Activity
Sign in / Sign up

Export Citation Format

Share Document