scholarly journals Chiral mesoporous silica nano-screws as an efficient biomimetic oral drug delivery platform through multiple topological mechanisms

2021 ◽  
Author(s):  
Yumei Wang ◽  
Jia Ke ◽  
Xianmou Guo ◽  
Kaijun Gou ◽  
Zhentao Sang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Delivery Platform

Effects of surface modification and size on oral drug delivery of mesoporous silica formulation

2018 ◽  
Vol 513 ◽  
pp. 736-747 ◽  
Author(s):  
Ying Wang ◽  
Yu Cui ◽  
Yating Zhao ◽  
Qinfu Zhao ◽  
Bing He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Mesoporous Silica ◽  
Oral Drug Delivery ◽  
Oral Drug

Evaluation of mesoporous silica nanoparticles for oral drug delivery – current status and perspective of MSNs drug carriers

Nanoscale ◽  
2017 ◽  
Vol 9 (40) ◽  
pp. 15252-15277 ◽  
Author(s):  
Justyna Florek ◽  
Romain Caillard ◽  
Freddy Kleitz
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Current Status ◽  
Oral Drug ◽  
Future Perspectives ◽  
Oral Drug Delivery Systems

Mesoporous silica nanocarriers are discussed as potential oral drug delivery systems, focusing on their advantages and limitations, and future perspectives.

What is the future for nanocrystal-based drug-delivery systems?

2020 ◽  
Vol 11 (4) ◽  
pp. 225-229 ◽  
Author(s):  
Zhongjian Chen ◽  
Wei Wu ◽  
Yi Lu
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Water Soluble ◽  
Oral Drug ◽  
Particle Properties ◽  
Novel Approach ◽  
The Future ◽  
Water Soluble Drugs ◽  
Delivery Platform

Nanocrystals are used as a drug-delivery platform for poorly water-soluble drugs and have had commercial success in oral drug delivery. We assert that the future of this technique is with cancer treatment and in the development of parenteral preparations. Advances in techniques for uniform and high-quality nanocrystals as well as deciphering the in vivo fate of nanocrystals are critical. The bottom-up technique allows for better control of particle properties, while the hybrid nanocrystal technique provides a novel approach to explore the in vivo fate of nanocrystals. Breakthroughs in these two techniques to further the development of nanocrystals are also discussed.

scholarly journals Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Tatyana Dyakonov ◽  
Chue Hue Yang ◽  
Derek Bush ◽  
Saujanya Gosangari ◽  
Shingai Majuru ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silk Fibroin ◽  
Conformational Changes ◽  
Oral Drug Delivery ◽  
Controlled Drug Delivery ◽  
Release Profile ◽  
Oral Drug ◽  
Delivery Platform ◽  
Model Drug

The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated. Attenuated total reflectance Fourier transform infrared spectroscopy (FTIR) has been used to observe conformational changes in SF- and drug-containing compositions. SF-based films, spray-dried microparticles, and matrixes loaded with naproxen were prepared. Both FTIR spectra and in vitro dissolution data demonstrated that SF β-sheet conformation regulates the release profile of naproxen. The controlled release characteristics of the SF-containing compositions were evaluated as a function of SF concentration, temperature, and exposure to dehydrating solvents. The results suggest that SF may be an attractive polymer for use in controlled drug delivery systems.

scholarly journals Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin

Pharmaceutics ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 4 ◽  
Author(s):  
Wei Zhang ◽  
Nan Zheng ◽  
Lu Chen ◽  
Luyao Xie ◽  
Mingshu Cui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Small Angle ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Pharmacokinetic Studies

The use of mesoporous silica nanoparticles (MSNs) in the field of oral drug delivery has recently attracted greater attention. However, there is still limited knowledge about how the shape of MSNs affects drug delivery capacity. In our study, we fabricated mesoporous silica nanorods (MSNRs) to study the shape effects of MSNs on oral delivery. MSNRs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and small-angle X-ray diffraction (small-angle XRD). Indomethacin (IMC), a non-steroidal anti-inflammatory agent, was loaded into MSNRs as model drug, and the drug-loaded MSNRs resulted in an excellent dissolution-enhancing effect. The cytotoxicity and in vivo pharmacokinetic studies indicated that MSNRs can be applied as a safe and efficient candidate for the delivery of insoluble drugs. The use of MSNs with a rod-like shape, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.

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