Development and validation of a two-dimensional population balance model for a supercritical CO2 antisolvent batch crystallization process

2020 ◽  
Vol 31 (8) ◽  
pp. 3191-3204
Author(s):  
Indu Muthancheri ◽  
Barry Long ◽  
Kevin M. Ryan ◽  
Luis Padrela ◽  
Rohit Ramachandran
Keyword(s):  
Supercritical Co2 ◽  
Crystallization Process ◽  
Population Balance ◽  
Balance Model ◽  
Population Balance Model ◽  
Two Dimensional ◽  
Batch Crystallization ◽  
Development And Validation

Two-dimensional population balance model with breakage of high aspect ratio crystals for batch crystallization

2008 ◽  
Vol 63 (12) ◽  
pp. 3271-3278 ◽  
Author(s):  
Kazuhiro Sato ◽  
Hidetada Nagai ◽  
Kazuhiro Hasegawa ◽  
Kunihiko Tomori ◽  
H.J.M. Kramer ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
High Aspect Ratio ◽  
Population Balance ◽  
Balance Model ◽  
Population Balance Model ◽  
Two Dimensional ◽  
Batch Crystallization

scholarly journals Comparison of One Dimensional and Two Dimensional Population Balance Model for Optimization of a Crystallization Process

2021 ◽  
Author(s):  
Tamar Rosenbaum ◽  
Victoria Mbachu ◽  
Niall Mitchell ◽  
John Gamble ◽  
Patricia Cho ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Crystallization Process ◽  
Population Balance ◽  
Seed Morphology ◽  
Balance Model ◽  
Population Balance Model ◽  
Two Dimensional ◽  
Population Balance Modeling ◽  
One Dimensional ◽  
The Impact

In this work, the advantage of two-dimensional population balance modeling (2D PBM) for a needle-shaped API is highlighted by comparing the one-dimensional population balance model (1D PBM) developed for an antisolvent crystallization with the 2D PBM. The API utilized for this work had extremely slow desupersaturation, and was not able to achieve solubility concentration despite a ~50 h seed bed age. While the 1D PBM is useful in optimizing the crystallization process to enhance desupersaturation, it is unable to match the particle size quantiles well. 2D PBM was necessary to probe the impact of crystallization process parameters on particle aspect ratio (AR). Simulations utilizing the 2D PBM indicated that regardless of antisolvent addition rate or seed morphology, the final material would still be high aspect ratio. This knowledge saved the investment of much time and efforts in trying to minimize particle AR with changes in crystallization processing parameters alone.

scholarly journals A two-dimensional population balance model for cell growth including multiple uptake systems

2018 ◽  
Vol 132 ◽  
pp. 966-981 ◽  
Author(s):  
V. Quedeville ◽  
H. Ouazaite ◽  
B. Polizzi ◽  
R.O. Fox ◽  
P. Villedieu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Population Balance ◽  
Balance Model ◽  
Population Balance Model ◽  
Two Dimensional

Multidimensional Population Balance Model Development and Validation of a Reactive Detergent Granulation Process

2015 ◽  
Vol 54 (3) ◽  
pp. 842-857 ◽  
Author(s):  
Anwesha Chaudhury ◽  
Ashutosh Tamrakar ◽  
Marek Schöngut ◽  
David Smrčka ◽  
František Štěpánek ◽  
...  
Keyword(s):  
Model Development ◽  
Population Balance ◽  
Balance Model ◽  
Population Balance Model ◽  
Granulation Process ◽  
Development And Validation
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