The lymphoid organ (LO) is an additional, prime target for decapod iridescent virus 1 (DIV1) in Penaeus vannamei

Aquaculture ◽  
2022 ◽  
Vol 547 ◽  
pp. 737482
Author(s):  
Piyachat Sanguanrut ◽  
Dararat Thaiue ◽  
Jumroensri Thawonsuwan ◽  
Diva J. Aldama-Cano ◽  
Timothy W. Flegel ◽  
...  
Author(s):  
Adriana Vallejo Isaza ◽  
Federico Newmark U.

An epizootiological study of the mayor deseases affecting the penaeid shrimp Penaeus vannamei was performed from june 1994 throuh august, 1995 in tree farms located on the colombian Carebbean coast. The presence and prevalence of infectious agents such as bacteria, protozoa, viral inclusions bodies and changes histopatologicals was determinated by means of gross examination and histological analysis.. The relationship between these infection agents and specific disease was also studies. The presence of some viruses such a Baculovirus penaei, IHHNV, TSV and LOVV, were determinated by demostration of the cytopathical effects characteristic of these agent. Additionaly, a logistic regression analysis was used to determine the relationship between some clinical signs and the presence of the infectious agent; the risk factor of having the disease, was also determinated; thus, shrimp with tumors and deformities presented a risk almost two times higher having IHHNV disease, as determined by the presence of inclusion bodies Cowdry A (CAI’s) than those whitout deformities; in an analogous way, the risk factor of presenting alterations in the lymphoid organ (L.O) was higher in organisms that have exposed to the TSV desease, than in those were not. Bacterial infections an infestations by protozoa were also analyzed. Some differences concerning the presence and prevalence of some of the diseases according to the geographical location of the farms and the different climatic conditions in such the cultivation started, wer observed. Some physical-chemical variables such as salinity, where related to the presence and prevalence of some clinical signs.


1999 ◽  
Vol 38 ◽  
pp. 93-105 ◽  
Author(s):  
KW Hasson ◽  
DV Lightner ◽  
LL Mohney ◽  
RM Redman ◽  
B White

2008 ◽  
Vol 32 (6) ◽  
pp. 613-626 ◽  
Author(s):  
Gun Anantasomboon ◽  
Raksawan Poonkhum ◽  
Nusara Sittidilokratna ◽  
Timothy W. Flegel ◽  
Boonsirm Withyachumnarnkul

Author(s):  
Demian Scherer ◽  
Dirk Wentura

Abstract. Recent theories assume a mutual facilitation in case of semantic overlap for concepts being activated simultaneously. We provide evidence for this claim using a semantic priming paradigm. To test for mutual facilitation of related concepts, a perceptual identification task was employed, presenting prime-target pairs briefly and masked, with an SOA of 0 ms (i.e., prime and target were presented concurrently, one above the other). Participants were instructed to identify the target. In Experiment 1, a cue defining the target was presented at stimulus onset, whereas in Experiment 2 the cue was not presented before the offset of stimuli. Accordingly, in Experiment 2, a post-cue task was merged with the perceptual identification task. We obtained significant semantic priming effects in both experiments. This result is compatible with the view that two concepts can both be activated in parallel and can mutually facilitate each other if they are related.


Author(s):  
Umme Hani ◽  
Shivananda Kandagalla ◽  
B.S. Sharath ◽  
K Jyothsna. ◽  
H Manjunatha.

: Hsp90 are molecular chaperones of chronic inflammatory proteins and have emerged as prime target for treatment of inflammation. Principal components from Curcuma longa and Camellia sinensis, Curcumin and EGC respectively possesses anti-inflammatory properties inhibiting cytokines responsible for inflammation. Both act on common pathways in upregulation of heme oxygenase 1 through Pkcδ-Nrf2 pathway and downregulation of Tlr4, which in turn suppress expression of Hsp90. Curcumin and EGC were also found to bind -N and -C terminal domain of Hsp90 respectively. Based on this, work was designed with network pharmacological approach. Hsp90 associated gene targets of Curcumin and EGC were collected from databases, and gene ontology studies were done. PPI were obtained from string database for specific genes involved in Pkcδ-Nrf2 and Tlr4 pathway. Protein interaction network was constructed by cytoscape, and networks of Hsp90, Curcumin and EGC were merged to get common genes involved in Pkcδ-Nrf2 and Tlr4 pathway. Cluego analysis was done for obtained common genes to identify functional behavior in human diseases. Main proteins involved were identified as key regulators in Pkcδ-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation. Docking was performed on main proteins, Hsp90, Pkcδ and Tlr4 with Curcumin and EGC, significant binding energy was obtained for docked complexes. Combinatorial effects of Curcumin and EGC were observed in Pkcδ-Nrf2 and Tlr4pathway. Present study is an attempt to unravel common pathways mediated in intervention of Curcumin and EGC for suppression of Hsp90 associated with inflammation.


Author(s):  
Vijay Kumar Vishvakarma ◽  
Ramesh Chandra ◽  
Prashant Singh

: Fever is a response of human body due to an increase the temperature against the certain stimuli. It may be associated with several reasons and one of the major causes of fever is mosquito bite. Fever due to dengue virus (DENV) infection is being paid most attention out of several other fevers because of a large number of deaths reported worldwide. Dengue virus is transmitted by biting of the mosquitoes, Aedes aegypti and Aedes albopictus. DENV1, DENV2, DENV3 and DENV4 are the four serotypes of dengue virus and these serotypes have 65% similarities in their genomic structure. Genome of DENV is composed of single stranded RNA and it encodes for the polyprotein. Structural and non-structural proteins (nsP) are the two major part of protese. Researchers have paid high attention on the non-structural protease (nsP) of DENV like nsP1, nsP2A, nsP2B, nsP3, nsP4A, nsP4B and nsP5. The NS2B-NS3 protease of DENV is the prime target of the researchers as it is responsible for the catalytic activity. In the present time, Dengvaxia (vaccine) is being recommended to the patients suffering severely due to DENV infection in few countries only. Till date, neither a vaccine nor an effective medicine is available to combat with all four serotypes. This review describes the fever, its causes and studies to cure the infection due to DENV using theoretical and experimental approaches.


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