Noninvasive brain stimulation over dorsolateral prefrontal cortex for pain perception and executive function in aging

2019 ◽  
Vol 81 ◽  
pp. 252-257
Author(s):  
JaeHyuk Lee ◽  
Yan Jin ◽  
SeJun Oh ◽  
TaeHyun Lim ◽  
BumChul Yoon
Keyword(s):  
Prefrontal Cortex ◽  
Executive Function ◽  
Brain Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Pain Perception ◽  
Noninvasive Brain Stimulation ◽  
Dorsolateral Prefrontal

scholarly journals Locations for noninvasive brain stimulation in treating depressive disorders: A combination of meta-analysis and resting-state functional connectivity analysis

2020 ◽  
Vol 54 (6) ◽  
pp. 582-590 ◽  
Author(s):  
Binlong Zhang ◽  
Jiao Liu ◽  
Tuya Bao ◽  
Georgia Wilson ◽  
Joel Park ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Brain Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Resting State Functional Connectivity ◽  
Noninvasive Brain Stimulation ◽  
Brain Surface ◽  
Dorsolateral Prefrontal

Objective: Many noninvasive brain stimulation techniques have been applied to treat depressive disorders. However, the target brain region in most noninvasive brain stimulation studies is the dorsolateral prefrontal cortex. Exploring new stimulation locations may improve the efficacy of noninvasive brain stimulation for depressive disorders. We aimed to explore potential noninvasive brain stimulation locations for depressive disorders through a meta-analysis and a functional connectivity approach. Methods: We conducted a meta-analysis of 395 functional magnetic resonance imaging studies to identify depressive disorder–associated brain regions as regions of interest. Then, we ran resting-state functional connectivity analysis with three different pipelines in 40 depression patients to find brain surface regions correlated with these regions of interest. The 10–20 system coordinates corresponding to these brain surface regions were considered as potential locations for noninvasive brain stimulation. Results: The 10–20 system coordinates corresponding to the bilateral dorsolateral prefrontal cortex, bilateral inferior frontal gyrus, medial prefrontal cortex, supplementary motor area, bilateral supramarginal gyrus, bilateral primary motor cortex, bilateral operculum, left angular gyrus and right middle temporal gyrus were identified as potential locations for noninvasive brain stimulation in depressive disorders. The coordinates were: posterior to F3, posterior to F4, superior to F3, posterior to F7, anterior to C4, P3, midpoint of F7–T3, posterior to F8, anterior to C3, midpoint of Fz–Cz, midpoint of Fz–Fp1, anterior to T4, midpoint of C3–P3, and anterior to C4. Conclusion: Our study identified several potential noninvasive brain stimulation locations for depressive disorders, which may serve as a basis for future clinical investigations.

Noninvasive Brain Stimulation of the Dorsolateral Prefrontal Cortex During Aesthetic Appreciation

2021 ◽  
pp. 97-101
Author(s):  
Marcos Nadal ◽  
Zaira Cattaneo ◽  
Camilo J. Cela-Conde
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Brain Stimulation ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Aesthetic Appreciation ◽  
Causal Association ◽  
Noninvasive Brain Stimulation ◽  
Dorsolateral Prefrontal ◽  
Stimulation Of

Several neuroimaging studies had shown that activity in the left dorsolateral prefrontal cortex (lDLPFC) was associated with aesthetic appreciation. But, was this a causal association? In the article under discussion, the authors used transcranial direct current stimulation (tDCS) to determine whether lDLPFC activity actually caused increased aesthetic appreciation. Their results showed that tDCS over lDLPFC caused liking for artworks and photographs to increase. They therefore concluded that the lDLPFC plays a causal role in visual aesthetic appreciation. The authors suggested that lDLPFC activity contributes to disengaging from a pragmatic orientation to stimuli, consisting mainly in identifying objects, adopting an aesthetic orientation, and focusing on those objects’ aesthetic qualities.

scholarly journals Transcranial Direct Current Stimulation May Improve Cognitive-Motor Function in Functionally Limited Older Adults

2018 ◽  
Vol 32 (9) ◽  
pp. 788-798 ◽  
Author(s):  
Brad Manor ◽  
Junhong Zhou ◽  
Rachel Harrison ◽  
On-Yee Lo ◽  
Thomas G. Travison ◽  
...  
Keyword(s):  
Older Adults ◽  
Prefrontal Cortex ◽  
Executive Function ◽  
Direct Current ◽  
Dual Task ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Dual Tasking ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal

Objective. To determine the effects of a transcranial direct current stimulation (tDCS) intervention with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) and cathode over the right supraorbital region, on cognition, mobility, and “dual-task” standing and walking in older adults with mild-to-moderate motor and cognitive impairments. Methods. A double-blinded, block-randomized, sham-controlled trial was conducted in 18 nondemented, ambulatory adults aged ⩾65 years with slow walking speed (⩽1.0 m/s) and “executive” dysfunction (Trail Making Test B score ⩽25th percentile of age- and education-matched norms). Interventions included ten 20-minute sessions of tDCS or sham stimulation. Cognition, mobility, and dual-task standing and walking were assessed at baseline, postintervention, and 2 weeks thereafter. Dual tasking was also assessed immediately before and after the first tDCS session. Results. Intervention compliance was high (mean ± SD = 9.5 ± 1.1 sessions) and no unexpected or serious side effects were reported. tDCS, compared with sham, induced improvements in the Montreal Cognitive Assessment total score ( P = .03) and specifically within the executive function subscore of this test ( P = .002), and in several metrics of dual-task standing and walking ( P < .05). Each of these effects persisted for 2 weeks. tDCS had no effect on the Timed Up-and-Go test of mobility or the Geriatric Depression Scale. Those participants who exhibited larger improvements in dual-task standing posture following the first tDCS session exhibited larger cognitive-motor improvements following 2 weeks of tDCS ( P < .04). Interpretation. tDCS intervention designed to stimulate the left dorsolateral prefrontal cortex may improve executive function and dual tasking in older adults with functional limitations.

Low-frequency brain stimulation to the left dorsolateral prefrontal cortex increases the negative impact of social exclusion among those high in personal distress

2016 ◽  
Vol 12 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Bernadette Mary Fitzgibbon ◽  
Melissa Kirkovski ◽  
Neil Wayne Bailey ◽  
Richard Hilton Thomson ◽  
Naomi Eisenberger ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Social Exclusion ◽  
Brain Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Negative Impact ◽  
Low Frequency ◽  
Personal Distress ◽  
Dorsolateral Prefrontal

The contribution of the dorsolateral prefrontal cortex to executive function

2007 ◽  
Vol 58 ◽  
pp. S62
Author(s):  
Ji Hyun Ko ◽  
Oury Monchi ◽  
Alain Ptito ◽  
Michael Petrides ◽  
Antonio_P. Strafella
Keyword(s):  
Prefrontal Cortex ◽  
Executive Function ◽  
Dorsolateral Prefrontal Cortex ◽  
Dorsolateral Prefrontal

Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments

2009 ◽  
Vol 2 (4) ◽  
pp. 234-237 ◽  
Author(s):  
Paul B. Fitzgerald ◽  
Jerome J. Maller ◽  
Kate E. Hoy ◽  
Richard Thomson ◽  
Zafiris J. Daskalakis
Keyword(s):  
Prefrontal Cortex ◽  
Brain Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Dorsolateral Prefrontal ◽  
Stimulation Experiments ◽  
Optimal Site

scholarly journals Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease

2016 ◽  
Vol 41 (8) ◽  
pp. 2171-2177 ◽  
Author(s):  
Robin J Borchert ◽  
Timothy Rittman ◽  
Luca Passamonti ◽  
Zheng Ye ◽  
Saber Sami ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prefrontal Cortex ◽  
Executive Function ◽  
Executive Functions ◽  
Dorsolateral Prefrontal Cortex ◽  
Anterior Cingulate ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
The Brain

Abstract Cognitive impairment is common in Parkinson’s disease (PD), but often not improved by dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits are therefore of growing interest. Imaging the brain at rest (‘task-free’) provides the opportunity to examine the impact of a candidate drug on many of the brain networks that underpin cognition, while minimizing task-related performance confounds. We test this approach using atomoxetine, a selective noradrenaline reuptake inhibitor that modulates the prefrontal cortical activity and can facilitate some executive functions and response inhibition. Thirty-three patients with idiopathic PD underwent task-free fMRI. Patients were scanned twice in a double-blind, placebo-controlled crossover design, following either placebo or 40-mg oral atomoxetine. Seventy-six controls were scanned once without medication to provide normative data. Seed-based correlation analyses were used to measure changes in functional connectivity, with the right inferior frontal gyrus (IFG) a critical region for executive function. Patients on placebo had reduced connectivity relative to controls from right IFG to dorsal anterior cingulate cortex and to left IFG and dorsolateral prefrontal cortex. Atomoxetine increased connectivity from the right IFG to the dorsal anterior cingulate. In addition, the atomoxetine-induced change in connectivity from right IFG to dorsolateral prefrontal cortex was proportional to the change in verbal fluency, a simple index of executive function. The results support the hypothesis that atomoxetine may restore prefrontal networks related to executive functions. We suggest that task-free imaging can support translational pharmacological studies of new drug therapies and provide evidence for engagement of the relevant neurocognitive systems.

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