Comment on “COVID-19 infection in children: A systematic review and meta-analysis of clinical features and laboratory findings”

Abstract Background Few studies have focused on exploring the clinical characteristics and outcomes of COVID-19 in older patients. We conducted this systematic review and meta-analysis to have a better understanding of the clinical characteristics of older COVID-19 patients. Methods A systematic search of PubMed and Scopus was performed from December 2019 to May 3rd, 2020. Observational studies including older adults (age ≥ 60 years) with COVID-19 infection and reporting clinical characteristics or outcome were included. Primary outcome was assessing weighted pooled prevalence (WPP) of severity and outcomes. Secondary outcomes were clinical features including comorbidities and need of respiratory support. Result Forty-six studies with 13,624 older patients were included. Severe infection was seen in 51% (95% CI– 36-65%, I2–95%) patients while 22% (95% CI– 16-28%, I2–88%) were critically ill. Overall, 11% (95% CI– 5-21%, I2–98%) patients died. The common comorbidities were hypertension (48, 95% CI– 36-60% I2–92%), diabetes mellitus (22, 95% CI– 13-32%, I2–86%) and cardiovascular disease (19, 95% CI – 11-28%, I2–85%). Common symptoms were fever (83, 95% CI– 66-97%, I2–91%), cough (60, 95% CI– 50-70%, I2–71%) and dyspnoea (42, 95% CI– 19-67%, I2–94%). Overall, 84% (95% CI– 60-100%, I2–81%) required oxygen support and 21% (95% CI– 0-49%, I2–91%) required mechanical ventilation. Majority of studies had medium to high risk of bias and overall quality of evidence was low for all outcomes. Conclusion Approximately half of older patients with COVID-19 have severe infection, one in five are critically ill and one in ten die. More high-quality evidence is needed to study outcomes in this vulnerable patient population and factors affecting these outcomes.

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Clinical features and treatment strategy of paraspinal arteriovenous shunt (PAVS): a systematic review with individual participants data meta-analysis

European Spine Journal ◽

10.1007/s00586-021-06831-2 ◽

2021 ◽

Author(s):

Jang Hun Kim ◽

Sang Hoon Yoon ◽

Suhk Que Park ◽

Seung-Pil Ban ◽

Byung-Kyu Cho

Keyword(s):

Systematic Review ◽

Clinical Features ◽

Treatment Strategy ◽

Meta Analysis ◽

Arteriovenous Shunt

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Epidemiology and clinical features of COVID-19 outbreaks in aged care facilities: A systematic review and meta-analysis

EClinicalMedicine ◽

10.1016/j.eclinm.2021.100771 ◽

2021 ◽

Vol 33 ◽

pp. 100771 ◽

Cited By ~ 1

Author(s):

Mohammad Rashidul Hashan ◽

Nicolas Smoll ◽

Catherine King ◽

Hannah Ockenden-Muldoon ◽

Jacina Walker ◽

...

Keyword(s):

Systematic Review ◽

Clinical Features ◽

Meta Analysis ◽

Aged Care ◽

Care Facilities ◽

Aged Care Facilities

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Indian scenario of IgA nephropathy: a systematic review and meta-analysis

African Health Sciences ◽

10.4314/ahs.v21i1.21 ◽

2021 ◽

Vol 21 (1) ◽

pp. 159-65

Author(s):

Anju Khairwa

Keyword(s):

Systematic Review ◽

Iga Nephropathy ◽

Clinical Features ◽

Meta Analysis ◽

Microscopic Hematuria ◽

Macroscopic Hematuria ◽

Female Ratio ◽

Cochrane Database ◽

Male Female Ratio ◽

Indian Scenario

Background: IgA nephropathy (IgAN) is most common primary glomerulopathy. There are variations in prevalence of IgAN and its clinical features in different studies from India. Aim: To summarize overall scenario of IgAN in India. Methods: In this systematic review, studies related to IgAN and related renal disease were included. Data searched were PubMed, EMBASE, Google scholar, and Cochrane Database from inception to 31st January 2019. Results: Total 49 studies (N=2480) were included: 21studies (N=2309) of primary IgAN; 19 studies (N=21) of Secondary IgAN; four studies (N=133) of IgA vasculitis nephropathy (IgAVN); and five studies (N=17) of IgA dominant nephropathy (IgADN). Prevalence of IgAN was 16.5% in India. Age of affected persons was ranging from 27.2±16.7 to 48.6±21.3 years . Male female ratio was 1.8:1. Clinical features of Primary IgAN, IgAVN, IgADN & Secondary IgAN were microscopic hematuria (49.6%, 44.4%, 15.6% & 59.5%), macroscopic hematuria (5.1%, 0.4%,40.9%,& 35.7%), Subnephrotic proteinuria (42.1%, 29.4%, 23.2%, & 52.3%), nephrotic proteinuria (16.0%, 4.4%, 76.8%,& 47.6%), and hypertension (25.8%,18.3%, 35.5%,& 47.6%).. The 24 hours proteinuria was ranging from 2.6±1.5 to 4.7±2.3 gm/day and serum creatinine (mg/dl) was ranging from 0.9±0 to 3.5±3.9 mg/dl. Histolomorphologically, all type of IgAN showed mesangial hypercellularity and Immunofluorescence revealed IgA deposition. Conclusion: The overall prevalence of primary IgAN in India was 16.5%. The subnephrotic proteinuria and microscopic hematuria were common clinical features. Keywords: IgA Nephropathy; histomorphology; prevalence; India.

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