Corticosteroids and Local Anesthetics Decrease Positive Effects of Platelet-Rich Plasma: An In Vitro Study on Human Tendon Cells

2012 ◽  
Vol 28 (5) ◽  
pp. 711-719 ◽  
Author(s):  
Bradley Carofino ◽  
David M. Chowaniec ◽  
Mary Beth McCarthy ◽  
James P. Bradley ◽  
Steve Delaronde ◽  
...  
Keyword(s):  
Local Anesthetics ◽  
Platelet Rich Plasma ◽  
In Vitro Study ◽  
Vitro Study ◽  
Positive Effects ◽  
Tendon Cells ◽  
Human Tendon

scholarly journals Dexamethasone decreases substance P expression in human tendon cells: an in vitro study

Rheumatology ◽  
2014 ◽  
Vol 54 (2) ◽  
pp. 318-323 ◽  
Author(s):  
R. Mousavizadeh ◽  
L. Backman ◽  
R. G. McCormack ◽  
A. Scott
Keyword(s):  
Substance P ◽  
In Vitro Study ◽  
Vitro Study ◽  
Tendon Cells ◽  
Human Tendon

scholarly journals Plasma Components and Platelet Activation Are Essential for the Antimicrobial Properties of Autologous Platelet-Rich Plasma: An In Vitro Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107813 ◽  
Author(s):  
Lorenzo Drago ◽  
Monica Bortolin ◽  
Christian Vassena ◽  
Carlo L. Romanò ◽  
Silvio Taschieri ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Platelet Rich Plasma ◽  
Antimicrobial Properties ◽  
In Vitro Study ◽  
Vitro Study ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Effects of Local Anesthetics on Smooth Muscle Tissue in Rat Trachea: An In Vitro Study

2020 ◽  
Vol 21 (4) ◽  
pp. 223-227
Author(s):  
Ali Onur Erdem ◽  
◽  
Varlik K. Erel ◽  
Ozlem Girit ◽  
Hasan Erdogan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Tissue ◽  
Local Anesthetics ◽  
In Vitro Study ◽  
Vitro Study ◽  
Smooth Muscle Tissue ◽  
Rat Trachea

scholarly journals Optimizing the safety of intradiscal platelet-rich plasma: an in vitro study with Cutibacterium acnes

2019 ◽  
Vol 14 (10) ◽  
pp. 955-967
Author(s):  
Meredith H Prysak ◽  
Cole G Lutz ◽  
Tyler A Zukofsky ◽  
Jordan M Katz ◽  
Peter A Everts ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Platelet Rich Plasma ◽  
In Vitro Study ◽  
Vitro Study ◽  
Post Inoculation ◽  
Bacterial Colony ◽  
Cutibacterium Acnes ◽  
Intradiscal Injection ◽  
Leukocyte Counts

Aim: The most common risk associated with intradiscal injection of platelet-rich plasma (PRP) is discitis with Cutibacterium acnes. It is hypothesized that antimicrobial activity of PRP can be enhanced through inclusion of leukocytes or antibiotics in the injectate. Materials & methods: Multiple PRP preparations of varying platelet and leukocyte counts were co-cultured with C. acnes with or without cefazolin, with viable bacterial colony counts being recovered at 0, 4, 24 and 48 hours post-inoculation. Results: A direct correlation between C. acnes recovery and granulocyte counts were observed. Conclusion: We observed the greatest antimicrobial activity with the leukocyte-rich, high platelet PRP preparation combined with an antibiotic in the injectate. However, cefazolin did not completely clear the bacteria in this assay.

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