P10.01 EFFECTS OF VEGFR-1 (FLT-1) INHIBITION DURING PREGNANCY ON THE UTERINE CIRCULATION OF THE MOUSE

2011 ◽  
Vol 5 (4) ◽  
pp. 188
Author(s):  
G. Osol ◽  
E. Khankin ◽  
A. Karumanchi
Keyword(s):  
Physiology ◽  
2009 ◽  
Vol 24 (1) ◽  
pp. 58-71 ◽  
Author(s):  
George Osol ◽  
Maurizio Mandala

Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodeling of the entire uterine circulation, as well as the creation of a new fetal vascular organ: the placenta. The process of remodeling involves a number of cellular processes, including hyperplasia and hypertrophy, rearrangement of existing elements, and changes in extracellular matrix. In this review, we provide information on uterine blood flow increases during pregnancy, the influence of placentation type on the distribution of uterine vascular resistance, consideration of the patterns, nature, and extent of maternal uterine vascular remodeling during pregnancy, and what is known about the underlying cellular mechanisms.


2001 ◽  
Vol 185 (3) ◽  
pp. 638-642 ◽  
Author(s):  
Eva E. Fulep ◽  
Yuri P. Vedernikov ◽  
George R. Saade ◽  
Robert E. Garfield

Author(s):  
István Szabó ◽  
László Csabay ◽  
Zorán Belics ◽  
Tibor Fekete ◽  
Zoltán Papp

1996 ◽  
Vol 98 (9) ◽  
pp. 2158-2166 ◽  
Author(s):  
C R Rosenfeld ◽  
B E Cox ◽  
T Roy ◽  
R R Magness

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