Circulating leukocyte telomere length and oxidative stress: A new target for statin therapy

2011 ◽  
Vol 219 (2) ◽  
pp. 753-760 ◽  
Author(s):  
Sebastien Saliques ◽  
Jean-Raymond Teyssier ◽  
Catherine Vergely ◽  
Luc Lorgis ◽  
Julie Lorin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Statin Therapy ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
And Oxidative Stress

scholarly journals Leukocyte Telomere Length in Major Depression: Correlations with Chronicity, Inflammation and Oxidative Stress - Preliminary Findings

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17837 ◽  
Author(s):  
Owen M. Wolkowitz ◽  
Synthia H. Mellon ◽  
Elissa S. Epel ◽  
Jue Lin ◽  
Firdaus S. Dhabhar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Major Depression ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
And Oxidative Stress

Author response for "Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression"

2020 ◽  
Author(s):  
Katia Martínez‐González ◽  
Azul Islas‐Hernández ◽  
José Darío Martínez‐Ezquerro ◽  
Federico Bermúdez‐Rattoni ◽  
Paola Garcia‐delaTorre
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Telomere Length ◽  
Murine Model ◽  
Author Response ◽  
Model Of Alzheimer’S Disease ◽  
Stress Variations ◽  
And Oxidative Stress

scholarly journals Telomere length and oxidative stress variations in a murine model of Alzheimer’s disease progression

2019 ◽  
Author(s):  
Katia Martínez-González ◽  
Azul Islas-Hernández ◽  
José Darío Martínez-Ezquerro ◽  
Federico Bermúdez-Rattoni ◽  
Paola Garcia-delaTorre
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Telomere Length ◽  
Brain Tissue ◽  
Murine Model ◽  
Blood Cells ◽  
Model Of Alzheimer’S Disease ◽  
And Oxidative Stress

AbstractAlzheimer’s Disease (AD) is the most common cause of dementia and aging is its major risk factor. Changes in telomere length have been associated with aging and some degenerative diseases. Our aim was to explore some of the molecular changes caused by the progression of AD in a transgenic murine model (3xTg-AD; B6; 129-Psen1 <tm1Mpm> Tg (APPSwe, tauP301L) 1Lfa). Telomere length was assessed by qPCR in both brain tissue and peripheral blood cells and compared between three age groups: 5, 9, and 13 months. In addition, a possible effect of oxidative stress on telomere length and AD progression was explored. Shorter telomeres were found in blood cells of older transgenic mice compared to younger and wild type mice but no changes in telomere length in the hippocampus. An increase in oxidative stress with age was found for all strains but no correlation was found between oxidative stress and shorter telomere length for transgenic mice. Telomere length and oxidative stress are affected by AD progression in the 3xTg-AD murine model. Changes in blood cells are more noticeable than changes in brain tissue, suggesting that systemic changes can be detected early in the disease in this murine model.

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