Characterization of cholesteryl ester-loaded human coronary vascular smooth muscle cell secretome. A source of potential biomarkers of coronary artery disease

2021 ◽  
Vol 331 ◽  
pp. e67-e68
Author(s):  
J.E.G. Rodríguez ◽  
A. Benitez Amaro ◽  
L. Claudi ◽  
J. Ni ◽  
C. Pallara ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Cholesteryl Ester ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Artery Disease ◽  
Potential Biomarkers

scholarly journals Associations between Vaspin Levels and Coronary Artery Disease

2020 ◽  
Vol 4 (3) ◽  
pp. 211-216
Author(s):  
Lutfu Askin ◽  
Okan Tanriverdi ◽  
Hakan Tibilli ◽  
Serdar Turkmen
Keyword(s):  
Coronary Artery Disease ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Foam Cell ◽  
Foam Cell Formation ◽  
Artery Disease

The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers. Although adipokine concentrations have been shown to be increased significantly in atherosclerotic lesions, the role adipokines in the atherosclerotic process remains to be elucidated. Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity. Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease. Vascular inflammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation. Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio. The therapeutic goal concerning vaspin is to fight atherosclerosis and related diseases, as well as to maintain vascular health.

scholarly journals TCF7L2 Regulation of GATA6-dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia

2018 ◽  
Author(s):  
Roshni Srivastava ◽  
Harshavardhan Rolyan ◽  
Yi Xie ◽  
Na Li ◽  
Neha Bhat ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Intimal Hyperplasia ◽  
Adult Stem Cells ◽  
Artery Disease

AbstractGenetic variations in Wnt-coreceptor LRP6 and Wnt-regulated transcription factor TCF7L2 have been among the strongest genetic signals for type2 diabetes (T2DM) and coronary artery disease (CAD). Mice with a CAD-linked LRP6 mutation exhibit obstructive coronary artery disease characterized by reduced TCF7L2 expression and dedifferentiation of vascular smooth muscle cell (VSMC). While TCF7L2 maintains stemness and promotes proliferation in embryonic tissues and adult stem cells, its role and mechanisms of action in VSMC differentiation is not understood. Using multiple mouse models, we demonstrate here that TCF7L2 promotes differentiation and inhibits proliferation of VSMCs. TCF7L2 accomplishes these effects by stabilization of GATA6 and upregulation of SM-MHC and cell cycle inhibitors. Accordingly, TCF7L2 haploinsufficient mice exhibited increased susceptibility to, while mice overexpressing TCF7L2 were protected against injury-induced intimal hyperplasia compared to wildtype littermates. Consequently, the overexpression of TCF7L2 in LRP6 mutant mice rescued the injury induced intimal hyperplasia. These novel findings imply cell type-specific functional role of TCF7L2 and provide critical insight into poorly understood mechanisms underlying pathogenesis of intimal hyperplasia.

scholarly journals Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease

Cell Reports ◽  
2015 ◽  
Vol 13 (4) ◽  
pp. 746-759 ◽  
Author(s):  
Roshni Srivastava ◽  
Jiasheng Zhang ◽  
Gwang-woong Go ◽  
Anand Narayanan ◽  
Timothy P. Nottoli ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Plasticity ◽  
Artery Disease

scholarly journals Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

PLoS Genetics ◽  
2018 ◽  
Vol 14 (11) ◽  
pp. e1007755 ◽  
Author(s):  
Vivek Nanda ◽  
Ting Wang ◽  
Milos Pjanic ◽  
Boxiang Liu ◽  
Trieu Nguyen ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Regulatory Mechanism ◽  
Disease Locus ◽  
Artery Disease

scholarly journals Erratum: Lazar-Karsten, P., et al. Generation and Characterization of Vascular Smooth Muscle Cell Lines Derived from a Patient with a Bicuspid Aortic Valve. Cells 2016, 5, 19.

Cells ◽  
2016 ◽  
Vol 5 (3) ◽  
pp. 36
Author(s):  
Pamela Lazar-Karsten ◽  
Gazanfer Belge ◽  
Detlev Schult-Badusche ◽  
Tim Focken ◽  
Arlo Radtke ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Aortic Valve ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Lines ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Bicuspid Aortic Valve
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