scholarly journals Early Stable Sinus Rhythm Associated With Greater Success 5 Years After Surgical Ablation

2018 ◽  
Vol 105 (5) ◽  
pp. 1370-1376 ◽  
Author(s):  
Niv Ad ◽  
Sari D. Holmes
2004 ◽  
Vol 26 (2) ◽  
pp. 323-329 ◽  
Author(s):  
Jan Pirk ◽  
Jan Bytesnik ◽  
Josef Kautzner ◽  
Petr Peichl ◽  
Vlastimil Vancura ◽  
...  

Author(s):  
Davy C. H. Cheng ◽  
Niv Ad ◽  
Janet Martin ◽  
Eva E. Berglin ◽  
Byung-Chul Chang ◽  
...  

Objectives This meta-analysis sought to determine whether surgical ablation improves clinical outcomes and resource utilization compared with no ablation in adult patients with persistent and permanent atrial fibrillation (AF) undergoing cardiac surgery. Methods A comprehensive search was undertaken to identify all randomized (RCT) and nonrandomized (non-RCT) controlled trials of surgical ablation versus no ablation in patients with AF undergoing cardiac surgery up to April 2009. The primary outcome was sinus rhythm. Secondary outcomes included survival and any other reported clinically relevant outcome or indicator of resource utilization. Odds ratios (OR) and weighted mean differences (WMD) and their 95% confidence intervals (95% CI) were analyzed as appropriate using the random effects model. Heterogeneity was measured using the I2 statistic. Meta-regression was performed to explore the relationship between the benefit from surgical AF and duration of follow-up. Results Thirty-three studies met the inclusion criteria (10 RCTs and 23 non-RCTs) for a total of 4647 patients. The number of patients in sinus rhythm was significantly improved at discharge in the surgical AF ablation group versus (68.6%) the surgery alone group (23.0%) in RCTs (OR 10.1, 95% CI 4.5–22.5) and non-RCTs (OR 7.15, 95% CI 3.42–14.95). This effect on sinus rhythm (74.6% vs. 18.4%) remained at follow-up of 1 to 5 years (OR 6.7, 95% CI 2.8–15.7 for RCT, and OR 15.5, 95% CI 6.6–36.7 for non-RCT). The risk of all-cause mortality at 30 days was not different between the groups in RCT (OR 1.20, 95% CI 0.52–3.16) or non-RCT studies (OR 0.99, 95% CI 0.52–1.87). In studies reporting all-cause mortality at 1 year or more (up to 5 years), mortality did not differ in RCT studies (OR 1.21, 95% CI 0.59–2.51) but was significantly reduced in non-RCT studies (OR 0.54, 95% CI 0.31–0.96). Stroke incidence was not reduced significantly; however, in meta-regression, the risk of stroke decreased significantly with longer follow-up. Other clinical outcomes were similar between groups. Operation time was significantly increased with surgical AF ablation; however, overall impact on length of stay was variable. Conclusions In patients with persistent or permanent AF who present for cardiac surgery, the addition of surgical AF ablation led to a significantly higher rate of sinus rhythm in RCT and non-RCT studies compared with cardiac surgery alone, and this effect remains robust over the longer term (1–5 years). Although non-RCT studies suggest the possibility of reduced risk of stroke and death, this remains to be proven in prospective RCTs with adequate power and follow-up.


Author(s):  
Albert L. Waldo

Based on data from several clinical trials, either rate control or rhythm control is an acceptable primary therapeutic strategy for patients with atrial fibrillation. However, since atrial fibrillation tends to recur no matter the therapy, rate control should almost always be a part of the treatment. If a rhythm control strategy is selected, it is important to recognize that recurrence of atrial fibrillation is common, but not clinical failure per se. Rather, the frequency and duration of episodes, as well as severity of symptoms during atrial fibrillation episodes should guide treatment decisions. Thus, occasional recurrence of atrial fibrillation despite therapy may well be clinically acceptable. However, for some patients, rhythm control may be the only strategy that is acceptable. In short, for most patients, either a rate or rhythm control strategy should be considered. However, for all patients, there are two main goals of therapy. One is to avoid stroke and/or systemic embolism, and the other is to avoid a tachycardia-induced cardiomyopathy. Also, because of the frequency of atrial fibrillation recurrence despite the treatment strategy selected, patients with stroke risks should receive anticoagulation therapy despite seemingly having achieved stable sinus rhythm. For patients in whom a rate control strategy is selected, a lenient approach to the acceptable ventricular response rate is a resting heart rate of 110 bpm, and probably 90 bpm. The importance of achieving and maintaining sinus rhythm in patients with atrial fibrillation and heart failure remains to be clearly established.


2020 ◽  
Vol 12 (3) ◽  
pp. 108-113
Author(s):  
Gilda Belli ◽  
Mattia Giovannini ◽  
Giulio Porcedda ◽  
Marco Moroni ◽  
Giancarlo la Marca ◽  
...  

Supraventricular tachyarrhythmia (SVT) is the most common type of arrhythmia in childhood. Management can be challenging with an associated risk of mortality. A female neonate was diagnosed with episodes of SVT, controlled antenatally with digoxin. Flecainide was commenced prophylactically at birth. Despite treatment, the infant developed a narrow complex tachycardia at 5 days of age. The electrocardiogram features were suggestive of either re-entry tachycardia or of automatic atrial tachycardia (AAT). Following several unsuccessful treatments, a wide complex tachycardia developed. A transesophageal electrophysiological study led to a diagnosis of AAT. Stable sinus rhythm was finally achieved through increasing daily administrations of flecainide up to six times a day, in association with nadolol. The shortening of intervals to this extent has never been reported before and supports the evidence of a personal, age-specific variability in pharmacokinetics of flecainide. Larger studies are needed to better define the appropriate dose and timing of administration.


Circulation ◽  
2012 ◽  
Vol 125 (18) ◽  
pp. 2175-2177 ◽  
Author(s):  
William G. Stevenson ◽  
Usha B. Tedrow

Circulation ◽  
2022 ◽  
Vol 145 (1) ◽  
pp. 84-86
Author(s):  
Jaya Batra ◽  
Angelo Biviano ◽  
Hirad Yarmohammadi

2021 ◽  
Author(s):  
Alexey Evtushenko ◽  
Vladimir Evtushenko ◽  
Anna Gusakova ◽  
Tatiana Suslova ◽  
Yulia Varlamova ◽  
...  

Abstract Background. The autonomic nervous system (ANS) plays an important role in modulation of cardiac electrophysiology and arrhythmogenesis. Disorders of the ANS components can be a prognostic factor of an unfavorable course of cardiovascular diseases. The aim of the study was to evaluate the association between efficacy of radiofrequency (RF) surgical ablation of long-standing persistent atrial fibrillation (AF) and neurohumoral transmitter levels as well as correlation between these data with myocardial iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake.Methods. Two groups of patients with acquired valvular heart disease were compared: patients with surgical AF ablation and patients with sinus rhythm.Results. The decrease of norepinephrine (NE) level in coronary sinus has a direct association with the heart-to-mediastinum ratio (p=0.02) and negative correlation with 123I-MIBG uptake defect (p=0.01). NE level decreased significantly after the main stage of surgery, both in patients with AF (p=0.0098) and sinus rhythm (p=0.0039). Furthermore, the significance (p=0.001) of the aortic root and coronary sinus gradient of NE level 0.405 pg/mL was determined as a cut-off value for efficacy evaluation of the RF denervation.Conclusion. The practical significance of the obtained results lies in the possibility of using the technique to predict the efficacy of the ‘Maze-IV’ procedure, which will allow assessing the risk of AF recurrence after ablation.


2020 ◽  
Vol 12 (3) ◽  
pp. 1-6
Author(s):  
Gilda Belli ◽  
Mattia Giovannini ◽  
Giulio Porcedda ◽  
Marco Moroni ◽  
Giancarlo la Marca ◽  
...  

Supraventricular tachyarrhythmia (SVT) is the most common type of arrhythmia in childhood. Management can be challenging with an associated risk of mortality. A female neonate was diagnosed with episodes of SVT, controlled antenatally with digoxin. Flecainide was commenced prophylactically at birth. Despite treatment, the infant developed a narrow complex tachycardia at 5 days of age. The electrocardiogram features were suggestive of either re-entry tachycardia or of automatic atrial tachycardia (AAT). Following several unsuccessful treatments, a wide complex tachycardia developed. A transesophageal electrophysiological study led to a diagnosis of AAT. Stable sinus rhythm was finally achieved through increasing daily administrations of flecainide up to six times a day, in association with nadolol. The shortening of intervals to this extent has never been reported before and supports the evidence of a personal, age-specific variability in pharmacokinetics of flecainide. Larger studies are needed to better define the appropriate dose and timing of administration.


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