This paper has introduced the TOD mode into the optimization design of all levels of urban public transport hubs, and probed TOD mode that effectively combines land use and urban public transport hubs. A TOD planning model for the land use of urban public transport hub was built by means of a multiple objective mathematical programming model. Four objectives were considered: to increase the express public transport capacity, to improve the environment of the planned region, to maximize the returns on investment, to ensure the balance of mixed land use. The model can be used for designing the rate of public transport hub area. The Shisheng public station area in Wuhan is chosen as case study to illustrate the model application and planning results. The result indicates that the model would be efficient in practice.