B lymphocytes, the gastrointestinal tract and autoimmunity

2021 ◽  
pp. 102777
Author(s):  
Moncef Zouali
Author(s):  
D.J. Unsworth

The gastrointestinal tract is protected by gut-associated lymphoid tissue that provides an environment where interaction occurs between luminal antigen and specially adapted immune tissue in Peyer’s patches (small intestine only) or lymphoid follicles. T and B lymphocytes primed in the gut migrate into the systemic circulation via the thoracic duct but home preferentially to the lamina propria of the intestine. Plasma cells of the lamina propria secrete immunoglobulin A as a dimer linked by a joining peptide....


Author(s):  
S.S. Terent'ev ◽  
◽  
V.I. Velikanov ◽  
A.V. Kljapnev ◽  
A.V. Gorina ◽  
...  

The purpose of our experiment was to study the effect of the combined administration of an immunomodulator and a synthetic analogue of estrone to cows 3-5 days before calving on the colostral immunity of calves. The result of the work showed that the calves obtained from such cows have a greater number of leukocytes, T-lymphocytes and B-lymphocytes at birth. A synthetic analogue of estrone probably cross the placenta and affect the fetus, which is reflected in the acceleration of the metabolism of the newborn. As a result, there was an accelerated assimilation of colostrum from the gastrointestinal tract, which was reflected in a sharp increase in the fractions of β- and γ-globulins one hour after drinking colostrum. In addition, the number of T-lymphocytes and B-lymphocytes has sharply increased.


1985 ◽  
Vol 6 (2) ◽  
pp. 52-58 ◽  
Author(s):  
Susan T. Bagley

AbstractThe genus Klebsiella is seemingly ubiquitous in terms of its habitat associations. Klebsiella is a common opportunistic pathogen for humans and other animals, as well as being resident or transient flora (particularly in the gastrointestinal tract). Other habitats include sewage, drinking water, soils, surface waters, industrial effluents, and vegetation. Until recently, almost all these Klebsiella have been identified as one species, ie, K. pneumoniae. However, phenotypic and genotypic studies have shown that “K. pneumoniae” actually consists of at least four species, all with distinct characteristics and habitats. General habitat associations of Klebsiella species are as follows: K. pneumoniae—humans, animals, sewage, and polluted waters and soils; K. oxytoca—frequent association with most habitats; K. terrigena— unpolluted surface waters and soils, drinking water, and vegetation; K. planticola—sewage, polluted surface waters, soils, and vegetation; and K. ozaenae/K. rhinoscleromatis—infrequently detected (primarily with humans).


Author(s):  
Dale E. Bockman ◽  
L. Y. Frank Wu ◽  
Alexander R. Lawton ◽  
Max D. Cooper

B-lymphocytes normally synthesize small amounts of immunoglobulin, some of which is incorporated into the cell membrane where it serves as receptor of antigen. These cells, on contact with specific antigen, proliferate and differentiate to plasma cells which synthesize and secrete large quantities of immunoglobulin. The two stages of differentiation of this cell line (generation of B-lymphocytes and antigen-driven maturation to plasma cells) are clearly separable during ontogeny and in some immune deficiency diseases. The present report describes morphologic aberrations of B-lymphocytes in two diseases in which second stage differentiation is defective.


2001 ◽  
Vol 120 (5) ◽  
pp. A552-A552
Author(s):  
M CURRY ◽  
T DEIGNAN ◽  
P COSTELLO ◽  
L GOLDENMASON ◽  
M DUFFY ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A695-A695
Author(s):  
M RUEHL ◽  
I SCHOENFELDER ◽  
R FARNDALE ◽  
G KNIGHT ◽  
R SOMASUNDARAM ◽  
...  

1963 ◽  
Vol 45 (5) ◽  
pp. 625-632 ◽  
Author(s):  
Margot Shiner ◽  
T.E. Waters ◽  
J.D. Allan Gray ◽  
R.A. Lambert

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