Clostridium difficile toxin B induces senescence in enteric glial cells: A potential new mechanism of Clostridium difficile pathogenesis

Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways

Scientific Reports ◽

10.1038/srep45569 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 10

Author(s):

Lara Macchioni ◽

Magdalena Davidescu ◽

Katia Fettucciari ◽

Maya Petricciuolo ◽

Leonardo Gatticchi ◽

...

Keyword(s):

Clostridium Difficile ◽

Nadph Oxidase ◽

Glial Cells ◽

Caspase 3 ◽

Toxin B ◽

Enteric Glial Cells ◽

NOX4 inhibition protects enteric glial cells against Clostridium difficile toxin B toxicity via attenuating oxidative and Endoplasmic reticulum stresses

Free Radical Research ◽

10.1080/10715762.2019.1649670 ◽

2019 ◽

Vol 53 (8) ◽

pp. 932-940 ◽

Cited By ~ 1

Author(s):

Yanmin Jiang ◽

Lan Xu ◽

Lin Yu ◽

Xiang Xu ◽

Chen Feng ◽

...

Keyword(s):

Endoplasmic Reticulum ◽

Clostridium Difficile ◽

Glial Cells ◽

Toxin B ◽

Enteric Glial Cells ◽

Enteric glial cells are susceptible to Clostridium difficile toxin B

Cellular and Molecular Life Sciences ◽

10.1007/s00018-016-2426-4 ◽

2016 ◽

Vol 74 (8) ◽

pp. 1527-1551 ◽

Cited By ~ 14

Author(s):

Katia Fettucciari ◽

Pamela Ponsini ◽

Davide Gioè ◽

Lara Macchioni ◽

Camilla Palumbo ◽

...

Keyword(s):

Clostridium Difficile ◽

Glial Cells ◽

Toxin B ◽

Enteric Glial Cells ◽

Faculty Opinions recommendation of Human alpha-defensins inhibit Clostridium difficile toxin B.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119826.575921 ◽

2008 ◽

Author(s):

Nur Alam

Keyword(s):

Clostridium Difficile ◽

Toxin B ◽

Faculty Opinions recommendation of Human alpha-defensins inhibit Clostridium difficile toxin B.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119826.575141 ◽

2008 ◽

Author(s):

Paul Kelly

Keyword(s):

Clostridium Difficile ◽

Toxin B ◽

Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultured cells

Experimental Cell Research ◽

10.1016/0014-4827(88)90156-5 ◽

1988 ◽

Vol 174 (1) ◽

pp. 215-229 ◽

Cited By ~ 50

Author(s):

Michael E. Ottlinger ◽

Shin Lin

Keyword(s):

Clostridium Difficile ◽

Cultured Cells ◽

Toxin B ◽

The small GTP-binding protein Rho is affected by Clostridium difficile toxin B

Toxicon ◽

10.1016/0041-0101(94)90261-5 ◽

1994 ◽

Vol 32 (4) ◽

pp. 399

Keyword(s):

Clostridium Difficile ◽

Binding Protein ◽

Gtp Binding Protein ◽

Toxin B ◽

Gtp Binding ◽

Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B

FEBS Journal ◽

10.1111/febs.14681 ◽

2018 ◽

Vol 286 (5) ◽

pp. 874-881 ◽

Cited By ~ 4

Author(s):

Peng Chen ◽

Liang Tao ◽

Zheng Liu ◽

Min Dong ◽

Rongsheng Jin

Keyword(s):

Clostridium Difficile ◽

Wnt Signaling ◽

Toxin B ◽

Structural Insight ◽

Clostridium Difficile Toxin B ◽

Insight Into

Biochemical studies on the effect of Clostridium difficile toxin B on actin in vivo and in vitro.

Infection and Immunity ◽

10.1128/iai.55.7.1610-1615.1987 ◽

1987 ◽

Vol 55 (7) ◽

pp. 1610-1615 ◽

Cited By ~ 28

Author(s):

M J Mitchell ◽

B E Laughon ◽

S Lin

Keyword(s):

Clostridium Difficile ◽

Toxin B ◽

Biochemical Studies ◽

The Effect of Lactoferrin and Pepsin-Treated Lactoferrin on IEC-6 Cell Damage Induced by Clostridium Difficile Toxin B

Shock ◽

10.1097/shk.0000000000000990 ◽

2018 ◽

Vol 50 (1) ◽

pp. 119-125 ◽

Cited By ~ 4

Author(s):

Kosuke Otake ◽

Norio Sato ◽

Ayako Kitaguchi ◽

Takayuki Irahara ◽

Satoru Murata ◽

...

Keyword(s):

Clostridium Difficile ◽

Cell Damage ◽

Toxin B ◽