Arsenic trioxide activates yes-associated protein by lysophosphatidic acid metabolism to selectively induce apoptosis of vascular smooth muscle cells

2022 ◽  
pp. 119211
Author(s):  
Hongchi Yu ◽  
Zhe Hou ◽  
Maolong Xiang ◽  
Fan Yang ◽  
Jia Ma ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Arsenic Trioxide ◽  
Vascular Smooth Muscle Cells ◽  
Lysophosphatidic Acid ◽  
Acid Metabolism ◽  
Muscle Cells

Effects of Lysophosphatidic Acid on Proliferation and Cytosolic Ca++ of Human Adult Vascular Smooth Muscle Cells in Culture

1999 ◽  
Vol 94 (5) ◽  
pp. 317-326 ◽  
Author(s):  
Isabelle Gennero ◽  
Jean-Marie Xuereb ◽  
Marie-Françoise Simon ◽  
Jean-Pierre Girolami ◽  
Jean-Louis Bascands ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Lysophosphatidic Acid ◽  
Muscle Cells ◽  
Cells In Culture ◽  
Human Adult

Preparation of Arsenic Trioxide-Loaded PLGA Nanoparticles and Investigation of its Inhibitory Effects on Proliferation of Rabbit Vascular Smooth Muscle Cells In Vitro

2009 ◽  
Vol 60-61 ◽  
pp. 125-129
Author(s):  
Su Su Zhao ◽  
Qin Lu ◽  
Dong Sheng Zhang
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Arsenic Trioxide ◽  
Vascular Smooth Muscle Cells ◽  
Drug Loading ◽  
Muscle Cells ◽  
Plga Nanoparticles ◽  
Inhibitory Effects

Proliferation and migration of vascular smooth muscle cells(VSMCs) into the sub-intimal space play an important role in intimal thickening in atherosclerosis and in-stent restenosis. Arsenic compounds are natural substances that have been used in the treatment of patients with acute promyelocytic leukemia (APL).And Arsenic trioxide (As2O3) is known to be a potent inhibitor of cell proliferation.The aim of this study was to prepare arsenic trioxide (As2O3) -loaded PLGA nanoparticles(As2O3-PLGA-NP) and investigate its general properties, preservation of As2O3 bioactivity and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(RVSMCs) in vitro. With PLGA as carrier,As2O3 drug delivery nanoparticles were prepared by w /o /w double-emulsion evaporation technique，and their inhibitory effects on Rabbit Vascular Smooth Muscle Cells(VSMCs) in vitro was investigated.The results of the experiment show the self-prepared As2O3-PLGA-NP were approximately spherical,with the mean diameter of 90±25.03 nm, and the average drug loading was 1.72% .The As2O3-PLGA-NP has drug sustained-release character and can prolong the phase of the inhibitory effect of As2O3 against RVSMCs.The As2O3-PLGA-NP do not reduce the biological activity of As2O3.

Mechanisms of Lysophosphatidic Acid–induced DNA Synthesis in Vascular Smooth Muscle Cells

2003 ◽  
Vol 41 (3) ◽  
pp. 381-387 ◽  
Author(s):  
Yan-Jun Xu ◽  
Satyajeet S. Rathi ◽  
Donald C. Chapman ◽  
Amarjit S. Arneja ◽  
Naranjan S. Dhalla
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Dna Synthesis ◽  
Vascular Smooth Muscle Cells ◽  
Lysophosphatidic Acid ◽  
Muscle Cells
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