#19 Anterior cingulate activation and error processing during interferon-α treatment: A pathway to cytokine-induced behavioral symptoms

Abstract The ability to detect and correct errors is a critical aspect of human cognition. Neuronal dysfunction in error processing has been reported in addictive disorders. The aim of this study was to investigate neural systems underlying error processing using event-related potentials (ERPs) and current source localization as well as neurocognitive executive function tests in patients with Internet gaming disorder (IGD). A total of 68 individuals (34 patients with IGD and 34 healthy controls [HCs]) were included, and two ERP components, error-related negativity (ERN) and error positivity (Pe), were extracted during a GoNogo task. Patients with IGD exhibited significantly reduced ERN and Pe amplitudes compared with HCs. Standardized low-resolution brain electromagnetic tomography (sLORETA) in between-group comparisons revealed that patients with IGD had decreased source activations of the Pe component in the anterior cingulate cortex (ACC) under the Nogo condition. These ERP changes were associated with deficits in decision-making and response inhibition in IGD patients. The results suggest that IGD may be associated with functional abnormalities in the ACC and alterations in neural activity related to both the early unconscious and the later conscious stages of error processing, as well as deficits in area of decision-making.

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Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia

Brain ◽

10.1093/brain/awg056 ◽

2003 ◽

Vol 126 (3) ◽

pp. 610-622 ◽

Cited By ~ 116

Author(s):

K. R. Laurens

Keyword(s):

Anterior Cingulate Cortex ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Error Processing ◽

Rostral Anterior Cingulate Cortex

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Maturational Changes in Anterior Cingulate and Frontoparietal Recruitment Support the Development of Error Processing and Inhibitory Control

Cerebral Cortex ◽

10.1093/cercor/bhn012 ◽

2008 ◽

Vol 18 (11) ◽

pp. 2505-2522 ◽

Cited By ~ 166

Author(s):

Katerina Velanova ◽

Mark E. Wheeler ◽

Beatriz Luna

Keyword(s):

Inhibitory Control ◽

Anterior Cingulate ◽

Error Processing

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Differential patterns of brain activation between hoarding disorder and obsessive-compulsive disorder during executive performance

Psychological Medicine ◽

10.1017/s0033291719000515 ◽

2019 ◽

Vol 50 (4) ◽

pp. 666-673

Author(s):

Maria Suñol ◽

Ignacio Martínez-Zalacaín ◽

Maria Picó-Pérez ◽

Clara López-Solà ◽

Eva Real ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Brain Activation ◽

Anterior Cingulate ◽

Error Processing ◽

Obsessive Compulsive ◽

Hoarding Disorder ◽

Compulsive Disorder ◽

Executive Performance ◽

Response Switching ◽

The Right

AbstractBackgroundPreliminary evidence suggests that hoarding disorder (HD) and obsessive-compulsive disorder (OCD) may show distinct patterns of brain activation during executive performance, although results have been inconclusive regarding the specific neural correlates of their differential executive dysfunction. In the current study, we aim to evaluate differences in brain activation between patients with HD, OCD and healthy controls (HCs) during response inhibition, response switching and error processing.MethodsWe assessed 17 patients with HD, 18 patients with OCD and 19 HCs. Executive processing was assessed inside a magnetic resonance scanner by means of two variants of a cognitive control protocol (i.e. stop- and switch-signal tasks), which allowed for the assessment of the aforementioned executive domains.ResultsOCD patients performed similar to the HCs, differing only in the number of successful go trials in the switch-signal task. However, they showed an anomalous hyperactivation of the right rostral anterior cingulate cortex during error processing in the switch-signal task. Conversely, HD patients performed worse than OCD and HC participants in both tasks, showing an impulsive-like pattern of response (i.e. shorter reaction time and more commission errors). They also exhibited hyperactivation of the right lateral orbitofrontal cortex during successful response switching and abnormal deactivation of frontal regions during error processing in both tasks.ConclusionsOur results support that patients with HD and OCD present dissimilar cognitive profiles, supported by distinct neural mechanisms. Specifically, while alterations in HD resemble an impulsive pattern of response, patients with OCD present increased error processing during response conflict protocols.

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Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment

Biological Psychiatry ◽

10.1016/j.biopsych.2005.03.033 ◽

2005 ◽

Vol 58 (3) ◽

pp. 190-196 ◽

Cited By ~ 152

Author(s):

Lucile Capuron ◽

Giuseppe Pagnoni ◽

Marina Demetrashvili ◽

Bobbi J. Woolwine ◽

Charles B. Nemeroff ◽

...

Keyword(s):

Interferon Alpha ◽

Anterior Cingulate ◽

Error Processing ◽

Interferon Alpha Treatment

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Intracerebral Error-Related Negativity in a Simple Go/NoGo Task

Journal of Psychophysiology ◽

10.1027/0269-8803.19.4.244 ◽

2005 ◽

Vol 19 (4) ◽

pp. 244-255 ◽

Cited By ~ 59

Author(s):

Milan Brázdil ◽

Robert Roman ◽

Pavel Daniel ◽

Ivan Rektor

Keyword(s):

Error Detection ◽

Intractable Epilepsy ◽

Event Related Potentials ◽

Anterior Cingulate ◽

Error Processing ◽

Supramarginal Gyrus ◽

Error Related Negativity ◽

Depth Electrodes ◽

Related Potentials ◽

Temporal Neocortex

Abstract: Performance monitoring represents a critical executive function of the human brain. In an effort to identify its anatomical and physiological aspects, a negative component of event-related potentials (ERPs), which occurs only on incorrect trials, has been used in the extensive investigation of error processing. This component has been termed “error-negativity” (Ne) or error-related negativity (ERN) and has been interpreted as a correlate of error detection. The aim of the present intracerebral ERP study was to contribute knowledge of the sources of the Ne/ERN, with a particular focus on the involvement of a frontomedian wall (FMW) in the genesis of this negativity. Seven patients with intractable epilepsy participated in the study. Depth electrodes were implanted to localize the seizure origin prior to surgical treatment. A total of 574 sites in the frontal, temporal, and parietal lobes were investigated. A simple Go/NoGo task was performed and EEG epochs with correct and erroneous motor responses were averaged independently using the response as the trigger. Ne/ERN was generated in multiple cortical structures, with the most consistent involvement being that of the FMW structures. Ne/ERN generators were revealed there in both the rostral and caudal anterior cingulate cortex (ACC), but also in the pre-SMA and in the parts of the medial frontal gyrus adjacent to the ACC. Different timing of activations between the rostral and caudal anterior cingulate Ne/ERN sources was observed in this study. Other neural sources of the Ne/ERN were found in the dorsolateral prefrontal cortex, in the orbitofrontal cortex, in the lateral temporal neocortex, and in one isolated case in the supramarginal gyrus. Our findings support the key role of the FMW in the genesis of Ne/ERN. At the same time, our findings suggest a different functional significance for the rostral and caudal ACC involvement in error processing. In addition to the FMW, the other prefrontal cortical sites, the lateral temporal neocortex, and the supramarginal gyrus seem to represent integral components of the brain's error monitoring system.

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Effect of interferon-α on cortical glutamate in patients with hepatitis C: a proton magnetic resonance spectroscopy study

Psychological Medicine ◽

10.1017/s0033291713001062 ◽

2013 ◽

Vol 44 (4) ◽

pp. 789-795 ◽

Cited By ~ 12

Author(s):

M. J. Taylor ◽

B. Godlewska ◽

J. Near ◽

D. Christmas ◽

J. Potokar ◽

...

Keyword(s):

Hepatitis C ◽

Major Depression ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Depressive Symptomatology ◽

Anterior Cingulate ◽

Interferon Α ◽

Resonance Spectroscopy ◽

Magnetic Resonance Spectroscopy Study ◽

Before And After

BackgroundThe development of depressive symptomatology is a recognized complication of treatment with the cytokine interferon-α (IFN-α) and has been seen as supporting inflammatory theories of the pathophysiology of major depression. Major depression has been associated with changes in glutamatergic activity and recent formulations of IFN-induced depression have implicated neurotoxic influences that could also lead to changes in glutamate function. The present study used magnetic resonance spectroscopy (MRS) to measure glutamate and its major metabolite glutamine in patients with hepatitis C who received treatment with pegylated IFN-α and ribavirin.MethodMRS measurements of glutamate and glutamine were taken from a 25 × 20 × 20 mm voxel including the pregenual anterior cingulate cortex in 12 patients before and after 4–6 weeks of treatment with IFN.ResultsIFN treatment led to an increase in cortical levels of glutamine (p = 0.02) and a significant elevation in the ratio of glutamine to glutamate (p < 0.01). Furthermore, changes in glutamine level correlated significantly with ratings of depression and anxiety at the time of the second scan.ConclusionsWe conclude that treatment with IFN-α is associated with MRS-visible changes in glutamatergic metabolism. However, the changes seen differ from those reported in major depression, which suggests that the pathophysiology of IFN-induced depression may be distinct from that of major depression more generally.

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