Diurnal cortisol levels predict improvement in functional outcomes in older adults in a post-acute rehabilitation setting

2010 ◽  
Vol 24 ◽  
pp. S33-S34
Author(s):  
L. Fiorentino ◽  
D. Saxbe ◽  
K. Josephson ◽  
S. Jouldjian ◽  
C.A. Alessi ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Outcomes ◽  
Diurnal Cortisol ◽  
Cortisol Levels ◽  
Acute Rehabilitation

scholarly journals Salivary Cortisol Patterns in People Living With Dementia

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 437-437
Author(s):  
Fanghong Dong ◽  
Liming Huang ◽  
Subhash Aryal ◽  
G Adriana Perez ◽  
Nancy Hodgson ◽  
...  
Keyword(s):  
Older Adults ◽  
Circadian Rhythm ◽  
Salivary Cortisol ◽  
Cortisol Awakening Response ◽  
Circadian Pattern ◽  
Clinical Dementia Rating ◽  
Diurnal Cortisol ◽  
The Mean ◽  
Cortisol Levels

Abstract Salivary cortisol has a well-documented circadian pattern in older adults. Yet, the pattern of salivary cortisol in persons living with dementia (PLWD) due to circadian rhythm disturbances is unknown. This study examined diurnal salivary cortisol patterns in 176 PLWD (mean age 73.6±8.8, 33.3% male, clinical dementia rating >=0.5) by collecting saliva at waking (AM1), 30 minutes after waking (AM2) and bedtime (PM) over two consecutive days. Cortisol awakening response (CAR) was calculated as the change between AM2 and AM1 cortisol levels. The mean baseline salivary cortisol levels (ug/dl) were 0.35 (SD:0.3) at AM1, 0.40 (SD:0.39) at AM2, and 0.19 (SD:0.4) at PM. On average, cortisol levels decreased from morning to evening, with 58% exhibiting a positive CAR (mean 0.05; SD:0.34). There were no significant associations between cortisol levels with age, sex, obesity, and comorbidities. The findings demonstrated that diurnal cortisol rhythms are maintained in PLWD with a flattened CAR.

scholarly journals Diurnal Cortisol and Functional Outcomes in Post-Acute Rehabilitation Patients

2012 ◽  
Vol 67A (6) ◽  
pp. 677-682 ◽  
Author(s):  
L. Fiorentino ◽  
D. Saxbe ◽  
C. A. Alessi ◽  
D. L. Woods ◽  
J. L. Martin
Keyword(s):  
Functional Outcomes ◽  
Diurnal Cortisol ◽  
Acute Rehabilitation

Biopsychosocial Patterning of Multimorbidity and Its Consequences

2018 ◽  
pp. 220-236
Author(s):  
Elliot Friedman ◽  
Beth LeBreton ◽  
Lindsay Fuzzell ◽  
Elizabeth Wehrpsann
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Functional Outcomes ◽  
The United States ◽  
Chronic Medical Conditions ◽  
Quality Of Life Research ◽  
Increased Risk ◽  
Over Time

By many estimates the majority of adults over age 65 have two or more chronic medical conditions (multimorbidity) and are consequently at increased risk of adverse functional outcomes. Nonetheless, many older adults with multimorbidity are able to maintain high levels of function and retain good quality of life. Research presented here is designed to understand the influences that help ensure better functional outcomes in these older adults. This chapter presents findings that draw on data from the Midlife in the United States study. The independent and interactive contributions of diverse factors to multimorbidity and changes in multimorbidity over time are reviewed. The degree that multimorbidity increases risk of cognitive impairment and disability is examined. The role of inflammation as a mediator is considered. Multimorbidity is increasingly the norm for older adults, so better understanding of factors contributing to variability in multimorbidity-related outcomes can lead to improved quality of life.

scholarly journals The influence of comorbid depression and overweight status on peripheral inflammation and cortisol levels

2021 ◽  
pp. 1-8
Author(s):  
Anna P. McLaughlin ◽  
Naghmeh Nikkheslat ◽  
Caitlin Hastings ◽  
Maria A. Nettis ◽  
Melisa Kose ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Significant Risk ◽  
Normal Weight ◽  
Cortisol Awakening Response ◽  
Peripheral Inflammation ◽  
Comorbid Depression ◽  
Diurnal Cortisol ◽  
Overweight Status ◽  
Multivariable Logistic Regression ◽  
Cortisol Levels

Abstract Background Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent to which depressive symptoms and overweight status contributed to increased inflammation and abnormal cortisol levels. Methods Participants were recruited through the Wellcome Trust NIMA Consortium. The sample of 216 participants consisted of 69 overweight patients with depression; 35 overweight controls; 55 normal-weight patients with depression and 57 normal-weight controls. Peripheral inflammation was measured as high-sensitivity C-Reactive Protein (hsCRP) in serum. Salivary cortisol was collected at multiple points throughout the day to measure cortisol awakening response and diurnal cortisol levels. Results Overweight patients with depression had significantly higher hsCRP compared with overweight controls (p = 0.042), normal-weight depressed patients (p < 0.001) and normal-weight controls (p < 0.001), after controlling for age and gender. Multivariable logistic regression showed that comorbid depression and overweight significantly increased the risk of clinically elevated hsCRP levels ⩾3 mg/L (OR 2.44, 1.28–3.94). In a separate multivariable logistic regression model, overweight status contributed most to the risk of having hsCRP levels ⩾3 mg/L (OR 1.52, 0.7–2.41), while depression also contributed a significant risk (OR 1.09, 0.27–2). There were no significant differences between groups in cortisol awakening response and diurnal cortisol levels. Conclusion Comorbid depression and overweight status are associated with increased hsCRP, and the coexistence of these conditions amplified the risk of clinically elevated hsCRP levels. Overweight status contributed most to the risk of clinically elevated hsCRP levels, but depression also contributed to a significant risk. We observed no differences in cortisol levels between groups.

scholarly journals Long‐term individual and population functional outcomes in older adults with atrial fibrillation

2021 ◽  
Author(s):  
Anna L. Parks ◽  
Sun Y. Jeon ◽  
W. John Boscardin ◽  
Michael A. Steinman ◽  
Alexander K. Smith ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Older Adults ◽  
Functional Outcomes

scholarly journals Socioeconomic Status, Race/Ethnicity, and Diurnal Cortisol Trajectories in Middle-Aged and Older Adults

2016 ◽  
pp. gbw080 ◽  
Author(s):  
Laura J. Samuel ◽  
David L. Roth ◽  
Brian S. Schwartz ◽  
Roland J. Thorpe ◽  
Thomas A. Glass
Keyword(s):  
Older Adults ◽  
Socioeconomic Status ◽  
Middle Aged ◽  
Diurnal Cortisol ◽  
Race Ethnicity

scholarly journals Effect of Improving Depression Care on Pain and Functional Outcomes Among Older Adults With Arthritis

JAMA ◽  
2003 ◽  
Vol 290 (18) ◽  
pp. 2428 ◽  
Author(s):  
Elizabeth H. B. Lin ◽  
Wayne Katon ◽  
Michael Von Korff ◽  
Lingqi Tang ◽  
John W. Williams, Jr ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Outcomes ◽  
Depression Care

scholarly journals Postoperative Functional Outcomes in Older Adults

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Zabecca S. Brinson ◽  
Victoria L. Tang ◽  
Emily Finlayson
Keyword(s):  
Older Adults ◽  
Functional Outcomes

scholarly journals IS VITAMIN D ASSOCIATED TO FUNCTIONAL OUTCOMES IN OLDER ADULTS ADMITTED TO REHABILITATION UNITS?

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 813-814
Author(s):  
D Lelli ◽  
L Pérez ◽  
A Calle ◽  
G Onder ◽  
A Morandi ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Functional Outcomes
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