scholarly journals Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease

2019 ◽  
Vol 75 ◽  
pp. 60-71 ◽  
Author(s):  
Vinko Palada ◽  
Aisha Siddiqah Ahmed ◽  
Anja Finn ◽  
Svante Berg ◽  
Camilla I. Svensson ◽  
...  
2019 ◽  
Vol 61 (6) ◽  
pp. 568-576 ◽  
Author(s):  
Michael D. Newton ◽  
Abigail A. Marek ◽  
Michael Planalp ◽  
Daniel K. Park ◽  
Kevin C. Baker ◽  
...  

2019 ◽  
Vol 21 (3) ◽  
pp. 187-196 ◽  
Author(s):  
Tomasz Kuligowski ◽  
Agnieszka Dębiec-Bąk ◽  
Anna Skrzek

Background. Low back pain (LBP) currently ranks among the most frequent musculoskeletal pathologies, and the average age of those affected is constantly decreasing. One of the causes of LBP is lumbar disc herniation (LDH). If untreated, it causes disability and leads to socio-economic problems. Traction techniques are a popular method of treating this condition. The stage of LDH (protrusion, extrusion) in young people appears to determine patients’ clinical status, necessitating diversification of treatment methods with regard to the type of damage. Material and methods. The study enrolled 37 people aged 22-35. The subjects underwent radiological evalu­ation (MRI), which constituted the basis for assigning them to one of two groups: a protrusion group (PRO) or an extrusion group (EXT). During the experiment, the patient was in the supine position while the therapist administered three-dimensional traction using a manual therapy belt. The Oswestry questionnaire, MRC scale, NRS, SLR test, PLE test and measurements of lumbar segment mobility were used for clinical evaluation. Statistica 12.5 was used to perform statistical calculations. Results. An analgesic effect was noted with regard to the following two parameters in both groups: ODI (PRO 28 → 14 and EXT 30 → 28, p <0.01) and NRS (PRO 6 → 2 and EXT 6 → 3, p <0.01). The subjects improved clinically, with regard to PLE (EXT 22% → 0%, p <0.04) and SLR (PRO 100% → 29%, p <0.01, and EXT 100% → 57%, p <0.01). Conclusions. 1. The type of intervertebral disc damage determines the functional status of young people with degenerative disc disease. 2. The study demonstrated and confirmed a positive effect of traction on the functional status of subjects with lumbar disc herniation. 3. Traction techniques are safe and can be successfully used in the treatment of LDH.


2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Ryan Indra ◽  
Muhammad Ilyas ◽  
Mirna Muis ◽  
Bachtiar Murtala ◽  
Andi Alfian ◽  
...  

Penelitian ini bertujuan mengetahui hubungan serum lipid darah dengan degenerative disc disease berdasarkan klasifikasi pfirrmann menggunakan magnetic resonance imaging lumbosacral pada pasien nyeri punggung bawah. Penelitian ini dilaksanakan di Departemen Radiologi RS. Dr. Wahidin Sudirohusodo Makassar mulai bulan Oktober 2018 sampai Januari 2019. Subjek sebanyak 52 orang dengan rentang usia 30 - 60 tahun. Metode yang digunakan adalah uji Spearman. Hasil penelitian menunjukkan terdapat korelasi antara kadar low-density lipoprotein (LDL) dan trigliserida serum dengan degenerative disc disease dengan nilai p=0.02 (p0.05). Semakin tinggi kadar LDL dan trigliserida maka derajat degerative disc disease cendereng semakin berat. Tidak terdapat korelasi antara HDL dengan degenerative disc disease. Secara statistik tidak terdapat korelasi antara kolesterol total dengan degenerative disc disease. Namun, didapatkan pada grafik nilai kolesterol total pada setiap derajat degenerative disc disease meningkat.


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