A Comparative Analysis of Graft Composition and Outcome with the Use of Single Dose Plerixafor as an Adjunct to GCSF Based PBSC Mobilisation for T Replete Haploidentical PBSC Transplantation with Post Transplantation Cyclophosphamide : A Pilot Study

IntroductionSexual dysfunction is one of the most common side effects of allogeneic haematopoietic stem cell transplantation (HSCT) for haematological cancers. Problems can persist between 5 and 10 years post-transplant and impact mood, couple intimacy and relationship satisfaction. Few intervention studies, however, target sexual dysfunction in patients post-HSCT. This pilot study aims to examine the feasibility and acceptability of implementing a psychosexual intervention for HSCT survivors and their partners post-transplantation.Methods and analysisFifteen allogeneic HSCT survivors and their partners will be recruited. Patients who are more than 3 months post-transplantation will be sent invitation letters describing the couples’ psychosexual intervention that will be offered through this study. The intervention will comprise two components: (1) psychosexual education about medical and behavioural treatment options for sexual dysfunction delivered by a haematology nurse consultant; (2) emotionally focused therapy-based relationship education programme for couples delivered by a clinical psychologist (four sessions of 1.5 hours each). Couples who consent to participate will be administered a series of measures assessing mood, relationship satisfaction and sexual dysfunction preintervention and post-intervention, as well as satisfaction with the intervention postintervention. Feasibility of the intervention will be examined via recording enrolment rate, adherence, compliance with completing outcome measures and fidelity of intervention delivery.Ethics and disseminationEthics approval has been obtained at the Peter MacCallum Cancer Centre in Melbourne, Australia. Results will be presented at national and international conferences and published in a peer-reviewed journal so that in can be accessed by clinicians involved in the care of allogeneic HSCT patients. If this intervention is found to be feasible and acceptable, its impact will be examined in a future randomised controlled trial and subsequently implemented as part of routine care in the allogeneic HSCT population.

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Single dose, extended-release epidural morphine compared to morphine equivalents for post-laparotomy pain in the gynecologic-oncology patient; A pilot study

Gynecologic Oncology ◽

10.1016/j.ygyno.2011.12.304 ◽

2012 ◽

Vol 125 ◽

pp. S125-S126

Author(s):

R. Stephenson ◽

A. Williams ◽

R. Taylor ◽

T. Denehy

Keyword(s):

Single Dose ◽

Pilot Study ◽

Epidural Morphine ◽

Extended Release ◽

Gynecologic Oncology ◽

Oncology Patient

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Comparative Analysis between Linear Measures from Bidimensional and Three-dimensional Images of the Face for Human Identification Purpose: A Pilot Study

Journal of Orofacial Sciences ◽

10.4103/jofs.jofs_289_20 ◽

2021 ◽

Vol 13 (1) ◽

pp. 19

Author(s):

RicardoH.A Silva ◽

PauloH.V Pinto ◽

Victor Jacometti ◽

JúliaG.D Pereira ◽

MarcoA.M.R Silva

Keyword(s):

Comparative Analysis ◽

Pilot Study ◽

Three Dimensional ◽

Human Identification ◽

The Face ◽

Three Dimensional Images

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Use of prostaglandin synthetic analogue E1 for uterus cervix preparation and labor induction

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2003-3-75-80 ◽

2003 ◽

Vol 2 (3) ◽

pp. 75-80

Author(s):

I. D. Yevtushenko ◽

A. Sh. Makhmutkhodzhayev ◽

T. V. Ivanova ◽

O. V. Parshina ◽

I. A. Ryzhova ◽

...

Keyword(s):

Single Dose ◽

Comparative Analysis ◽

Pregnant Women ◽

Perinatal Outcomes ◽

Labor Induction ◽

Prostaglandin E ◽

Synthetic Analogue ◽

Symptom Development ◽

Labor Duration ◽

The One

A clinical prospective examination of 90 women with complete pregnancy and indications for labor induction because of unsatisfactory maturity of uterus cervix has been made. The aim was to create a comparative analysis of efficiency of intravaginal introduction of prostaglandin synthetic analogue E1 misoprostol («Sytotec») and intracervical introduction of prostaglandin E2 dinoprostone («Prepidil» gel) for uterus cervix preparation and labor induction at complete pregnancy. Misoprostol in a dose of 25 mkg has been introduced to pregnant women of the 1 group (n=44), every 4 hours not more than 3 times. In case of discharge of waters or labor activity the second introduction has not been done. Dinoprostone has been introduced intracervically in a single dose to pregnant women of the 2 group (n=46). The use of misoprostol has been accompanied by spontaneous beginning of labor activity by 2 times more often than the use of dinoprostone. The quantity of vaginal births within 12 and 24 hours of observation has been surely greater and the duration of time between the beginning of introduction and labor has been surely smaller in the group of women received misoprostol as compared to the one received dinoprostone. It has not been revealed any differences between examined groups by the frequency of uterus hyperstimulation symptom development, labor duration, frequency of abdominal and vaginal labor, as well as perinatal outcomes.

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Progression of Endothelial Dysfunction, Atherosclerosis, and Arterial Stiffness in Stable Kidney Transplant Patients: A Pilot Study

10.21203/rs.2.16074/v1 ◽

2019 ◽

Author(s):

Joey Junarta ◽

Nina Hojs ◽

Robin Ramphul ◽

Racquel Lowe-Jones ◽

Juan C Kaski ◽

...

Keyword(s):

Pilot Study ◽

Kidney Transplant ◽

Cardiovascular Event ◽

Intima Media Thickness ◽

Post Transplantation ◽

Vascular Abnormalities ◽

Transplant Patients ◽

Diabetes Status ◽

Kidney Transplant Patients ◽

Event Rates

Abstract Background Kidney transplant patients suffer from vascular abnormalities and high cardiovascular event rates, despite initial improvements post-transplantation. The nature of the progression of vascular abnormalities in the longer term is unknown. This pilot study investigated changes in vascular abnormalities over time in stable kidney transplant patients long after transplantation. Methods Brachial artery flow-mediated dilation (FMD), nitroglycerin-mediated dilation, carotid-femoral pulse wave velocity (cf-PWV), ankle-brachial pressure index, and common carotid artery intima-media thickness (CCA-IMT) were assessed in 18 kidney transplant patients and 17 controls at baseline and 3-6 months after. Results There was no difference in age (51±13 vs. 46±11; P=0.19), body mass index (26±5 vs. 25±3; P=0.49), serum cholesterol (4.54±0.96 vs. 5.14±1.13; P=0.10), systolic blood pressure (BP) (132±12 vs. 126±12; P=0.13), diastolic BP (82±9 vs. 77±8; P=0.10), or diabetes status (3 vs. 0; P=0.08) between transplant patients and controls. No difference existed in vascular markers between patients and controls at baseline. In transplant patients, FMD decreased (-1.52±2.74; P=0.03), cf-PWV increased (0.62±1.06; P=0.03), and CCA-IMT increased (0.35±0.53; P=0.02). No changes were observed in controls. Conclusions Markers of vascular structure and function worsen in the post-transplant period on long-term follow-up, which may explain the continued high cardiovascular event rates in this population.

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