Brain aging, memory impairment and oxidative stress: A study in Drosophila melanogaster

2014 ◽  
Vol 259 ◽  
pp. 60-69 ◽  
Author(s):  
Mohammad Haddadi ◽  
Samaneh Reiszadeh Jahromi ◽  
B.K. Chandrasekhar Sagar ◽  
Rajashekhar K. Patil ◽  
T. Shivanandappa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Memory Impairment ◽  
Brain Aging ◽  
And Oxidative Stress

A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer's disease

2019 ◽  
Vol 109 ◽  
pp. 107-117 ◽  
Author(s):  
Franciele Martini ◽  
Suzan Gonçalves Rosa ◽  
Isabella Pregardier Klann ◽  
Bruna Cruz Weber Fulco ◽  
Fabiano Barbosa Carvalho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Sporadic Alzheimer’S Disease ◽  
And Oxidative Stress

scholarly journals Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Jung-Eun Lee ◽  
Hye-Jin Kwon ◽  
Juli Choi ◽  
Ji-Seon Seo ◽  
Pyung-Lim Han
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Chronic Stress ◽  
Brain Aging ◽  
Aged Mice ◽  
Upstream Regulator ◽  
Underlying Mechanisms ◽  
Old Mice ◽  
And Oxidative Stress ◽  
Young Mice

AbstractBrain aging proceeds with cellular and molecular changes in the limbic system. Aging-dependent changes might affect emotion and stress coping, yet the underlying mechanisms remain unclear. Here, we show aged (18-month-old) mice exhibit upregulation of NADPH oxidase and oxidative stress in the hippocampus, which mirrors the changes in young (2-month-old) mice subjected to chronic stress. Aged mice that lack p47phox, a key subunit of NADPH oxidase, do not show increased oxidative stress. Aged mice exhibit depression-like behavior following weak stress that does not produce depressive behavior in young mice. Aged mice have reduced expression of the epigenetic factor SUV39H1 and its upstream regulator p-AMPK, and increased expression of Ppp2ca in the hippocampus—changes that occur in young mice exposed to chronic stress. SUV39H1 mediates stress- and aging-induced sustained upregulation of p47phox and oxidative stress. These results suggest that aging increases susceptibility to stress by upregulating NADPH oxidase in the hippocampus.

Scopolamine-Induced Memory Impairment Is Alleviated by Xanthotoxin: Role of Acetylcholinesterase and Oxidative Stress Processes

2018 ◽  
Vol 9 (5) ◽  
pp. 1184-1194 ◽  
Author(s):  
Krystyna Skalicka-Wozniak ◽  
Barbara Budzynska ◽  
Grazyna Biala ◽  
Anna Boguszewska-Czubara
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
And Oxidative Stress

The Effects of Age on Radiation Resistance and Oxidative Stress in Adult Drosophila melanogaster

2008 ◽  
Vol 169 (6) ◽  
pp. 707-711 ◽  
Author(s):  
Vijay Parashar ◽  
Stewart Frankel ◽  
Alan G. Lurie ◽  
Blanka Rogina
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Radiation Resistance ◽  
And Oxidative Stress ◽  
Adult Drosophila

scholarly journals Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Harquin Simplice Foyet ◽  
Hervé Hervé Ngatanko Abaïssou ◽  
Eglantine Wado ◽  
Emmanuel Asongalem Acha ◽  
Ciobica Alin
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
Cholinergic Dysfunction ◽  
Stress Damage ◽  
And Oxidative Stress

scholarly journals Acupuncture Reduces Memory Impairment and Oxidative Stress and Enhances Cholinergic Function in an Animal Model of Alcoholism

2015 ◽  
Vol 8 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Nattaporn Phunchago ◽  
Jintanaporn Wattanathorn ◽  
Kowit Chaisiwamongkol ◽  
Supaporn Muchimapura ◽  
Wipawee Thukham-mee
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Memory Impairment ◽  
Cholinergic Function ◽  
And Oxidative Stress

scholarly journals Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice

2009 ◽  
Vol 157 (7) ◽  
pp. 1270-1277 ◽  
Author(s):  
P Lu ◽  
T Mamiya ◽  
LL Lu ◽  
A Mouri ◽  
LB Zou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Memory Impairment ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
And Oxidative Stress
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