Acupuncture Reduces Memory Impairment and Oxidative Stress and Enhances Cholinergic Function in an Animal Model of Alcoholism

To date, the effective preventive paradigm against mild cognitive impairment (MCI) is required. Therefore, we aimed to determine whetherMangifera indicafruit extract, a substance possessing antioxidant and cognitive enhancing effects, could improve memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model of mild cognitive impairment. Male Wistar rats, weighing 180–200 g, were orally given the extract at doses of 12.5, 50, and 200 mg·kg−1BW for 2 weeks before and 1 week after the bilateral injection of AF64A (icv). At the end of study, spatial memory, cholinergic neurons density, MDA level, and the activities of SOD, CAT, and GSH-Px enzymes in hippocampus were determined. The results showed that all doses of extract could improve memory together with the decreased MDA level and the increased SOD and GSH-Px enzymes activities. The increased cholinergic neurons density in CA1 and CA3 of hippocampus was also observed in rats treated with the extract at doses of 50 and 200 mg·kg−1BW. Therefore, our results suggested thatM. indica, the potential protective agent against MCI, increased cholinergic function and the decreased oxidative stress which in turn enhanced memory. However, further researches are essential to elucidate the possible active ingredients and detail mechanism.

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Neuroprotective Effect of <i>Phyllanthus acidus</i> L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Advances in Alzheimer s Disease ◽

10.4236/aad.2016.52005 ◽

2016 ◽

Vol 05 (02) ◽

pp. 53-72 ◽

Cited By ~ 15

Author(s):

Md. Sahab Uddin ◽

Abdullah Al Mamun ◽

Md. Saddam Hossain ◽

Muhammad Ashaduzzaman ◽

Md. Ali Asif Noor ◽

...

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Animal Model ◽

Learning And Memory ◽

Memory Impairment ◽

Neuroprotective Effect ◽

Phyllanthus Acidus ◽

And Oxidative Stress

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Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/918426 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 11

Author(s):

Nattaporn Phunchago ◽

Jintanaporn Wattanathorn ◽

Kowit Chaisiwamongkol

Keyword(s):

Oxidative Stress ◽

Memory Impairment ◽

Cognitive Deficit ◽

Brain Dysfunction ◽

Cholinergic Function ◽

Memory Assessment ◽

Neuron Density ◽

Ethanol Dependence ◽

Male Wistar Rats ◽

And Oxidative Stress

Oxidative stress plays an important role in brain dysfunctions induced by alcohol. Since less therapeutic agent against cognitive deficit and brain damage induced by chronic alcohol consumption is less available, we aimed to assess the effect ofTiliacora triandraextract, a plant possessing antioxidant activity, on memory impairment, neuron density, cholinergic function, and oxidative stress in hippocampus of alcoholic rats. Male Wistar rats were induced ethanol dependence condition by semivoluntary intake of alcohol for 15 weeks. Alcoholic rats were orally givenT. triandraat doses of 100, 200, and 400 mg·kg−1BW for 14 days. Memory assessment was performed every 7 days while neuron density, activities of AChE, SOD, CAT, and GSH-Px and, MDA level in hippocampus were assessed at the end of study. Interestingly, the extract mitigated the increased escape latency, AChE and MDA level. The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol. These data suggested that the extract improved memory deficit in alcoholic rats partly via the decreased oxidative stress and the suppression of AChE. Therefore,T. triandrais the potential reagent for treating brain dysfunction induced by alcohol. However, further researches are necessary to understand the detail mechanism and possible active ingredient.

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SHR/NCrl rats as a model of ADHD can be discriminated from controls based on their brain, blood, or urine metabolomes

Translational Psychiatry ◽

10.1038/s41398-021-01344-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Camille Dupuy ◽

Pierre Castelnau ◽

Sylvie Mavel ◽

Antoine Lefevre ◽

Lydie Nadal-Desbarats ◽

...

Keyword(s):

Oxidative Stress ◽

Attention Deficit Hyperactivity Disorder ◽

Animal Model ◽

Metabolic Pathways ◽

Neurodevelopmental Disorder ◽

Hyperactivity Disorder ◽

Pathophysiological Condition ◽

The Brain ◽

And Oxidative Stress ◽

Peripheral Samples

AbstractAttention-Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorder characterized by inattention, impulsivity, and hyperactivity. The neurobiological mechanisms underlying ADHD are still poorly understood, and its diagnosis remains difficult due to its heterogeneity. Metabolomics is a recent strategy for the holistic exploration of metabolism and is well suited for investigating the pathophysiology of diseases and finding molecular biomarkers. A few clinical metabolomic studies have been performed on peripheral samples from ADHD patients but are limited by their access to the brain. Here, we investigated the brain, blood, and urine metabolomes of SHR/NCrl vs WKY/NHsd rats to better understand the neurobiology and to find potential peripheral biomarkers underlying the ADHD-like phenotype of this animal model. We showed that SHR/NCrl rats can be differentiated from controls based on their brain, blood, and urine metabolomes. In the brain, SHR/NCrl rats displayed modifications in metabolic pathways related to energy metabolism and oxidative stress further supporting their importance in the pathophysiology of ADHD bringing news arguments in favor of the Neuroenergetic theory of ADHD. Besides, the peripheral metabolome of SHR/NCrl rats also shared more than half of these differences further supporting the importance of looking at multiple matrices to characterize a pathophysiological condition of an individual. This also stresses out the importance of investigating the peripheral energy and oxidative stress metabolic pathways in the search of biomarkers of ADHD.

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