Unbiased stereological analysis of the fate of oligodendrocyte progenitor cells in the adult mouse brain and effect of reference memory training

2017 ◽  
Vol 329 ◽  
pp. 127-139 ◽  
Author(s):  
Jenna J. Boulanger ◽  
Claude Messier
Keyword(s):  
Progenitor Cells ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Reference Memory ◽  
Memory Training ◽  
Oligodendrocyte Progenitor Cells ◽  
Adult Mouse Brain ◽  
Oligodendrocyte Progenitor ◽  
Stereological Analysis

scholarly journals Comparative Analysis of the Frequency and Distribution of Stem and Progenitor Cells in the Adult Mouse Brain

Stem Cells ◽  
2008 ◽  
Vol 26 (4) ◽  
pp. 979-987 ◽  
Author(s):  
Mohammad G. Golmohammadi ◽  
Daniel G. Blackmore ◽  
Beatrice Large ◽  
Hassan Azari ◽  
Ebrahim Esfandiary ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Progenitor Cells ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Adult Mouse Brain ◽  
Stem And Progenitor Cells

scholarly journals A Novel Pharmacogenetic Model for Highly Efficient Ablation of Oligodendrocyte Progenitor Cells in the Adult Mouse CNS

2021 ◽  
Author(s):  
Yao Lulu Xing ◽  
Bernard H.A. Chuang ◽  
Jasmine Poh ◽  
Kaveh Moradi ◽  
Stanislaw Mitew ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Adult Mouse ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Cell Ablation ◽  
Novel Approach ◽  
Anterior Forebrain ◽  
Health And Disease ◽  
The Brain ◽  
Advance Knowledge

Approaches to investigate adult oligodendrocyte progenitor cells (OPCs) by targeted cell ablation in the rodent central nervous system have been limited by methodological challenges resulting in only partial and transient OPC depletion. We have developed a novel pharmacogenetic model of conditional OPC ablation, resulting in the elimination of 99.7% of all OPCs throughout the brain. By combining recombinase-based transgenic and viral strategies for targeting of OPCs and ventricular-subventricular zone (V-SVZ)-derived neural precursor cells (NPCs), we found that new PDGFRα-expressing cells born in the V-SVZ repopulated the OPC-deficient brain starting 12 days after OPC ablation. Our data reveal that OPC depletion induces V-SVZ-derived NPCs to generate vast numbers of PDGFRα+/NG2+ cells with the capacity to migrate and proliferate extensively throughout the dorsal anterior forebrain. Further application of this novel approach to ablate OPCs will advance knowledge of the function of both OPCs and oligodendrogenic NPCs in health and disease.

Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid

2006 ◽  
Vol 27 (4) ◽  
pp. 606-613 ◽  
Author(s):  
M. Calafiore ◽  
G. Battaglia ◽  
A. Zappalà ◽  
E. Trovato-Salinaro ◽  
F. Caraci ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Adult Mouse Brain ◽  
Neuronal Phenotype ◽  
Β Amyloid

scholarly journals Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain

2011 ◽  
Vol 117 (3) ◽  
pp. 208-212 ◽  
Author(s):  
Koichi Kawada ◽  
Masayuki Kaneko ◽  
Yasuyuki Nomura ◽  
Seisuke Mimori ◽  
Hiroshi Hamana ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mouse Brain ◽  
Ubiquitin Ligase ◽  
Adult Mouse ◽  
Adult Mouse Brain ◽  
Neural Stem Progenitor Cells

scholarly journals Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain

2020 ◽  
Author(s):  
Rebecca M. Beiter ◽  
Anthony Fernández-Castañeda ◽  
Courtney Rivet-Noor ◽  
Andrea Merchak ◽  
Robin Bai ◽  
...  
Keyword(s):  
Brain Function ◽  
Adult Mouse ◽  
Adult Brain ◽  
Oligodendrocyte Progenitor Cells ◽  
Biological Processes ◽  
Adult Mouse Brain ◽  
Oligodendrocyte Progenitor ◽  
Active Population ◽  
Rna In Situ Hybridization

ABSTRACTOligodendrocyte progenitor cells (OPCs) are a mitotically active population of glia that comprise approximately 5% of the adult brain. OPCs maintain their proliferative capacity and ability to differentiate in oligodendrocytes throughout adulthood, but relatively few mature oligodendrocytes are produced following developmental myelination. Recent work has begun to demonstrate that OPCs likely perform multiple functions in both homeostasis and disease, and can significantly impact behavioral phenotypes such as food intake and depressive symptoms. However, the exact mechanisms through which OPCs might influence brain function remains unclear. In this work, we demonstrate that OPCs are transcriptionally diverse and separate into three distinct populations in the homeostatic brain. These three groups show distinct transcriptional signatures and enrichment of biological processes unique to individual OPC populations. We have validated these OPC populations using multiple methods, including multiplex RNA in situ hybridization and RNA flow cytometry. This study provides an important resource that profiles the transcriptome of adult OPCs and will provide a significant foundation for further investigation into novel OPC functions.

scholarly journals Lectins as a Tool for Detecting Neural Stem/Progenitor Cells in the Adult Mouse Brain

2010 ◽  
Vol 294 (2) ◽  
pp. 305-321 ◽  
Author(s):  
Masaaki Kitada ◽  
Yasumasa Kuroda ◽  
Mari Dezawa
Keyword(s):  
Progenitor Cells ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Adult Mouse Brain ◽  
Neural Stem Progenitor Cells
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