Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction

2018 ◽  
Vol 350 ◽  
pp. 31-43 ◽  
Author(s):  
L. Rajagopal ◽  
D. Soni ◽  
H.Y. Meltzer
2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 419-419
Author(s):  
J. Kang ◽  
J. Hyun ◽  
M. Sliwinski ◽  
J.A. Mogle

2021 ◽  
Author(s):  
Shuji Tsuda ◽  
Hiroki Inagaki ◽  
Tsuyoshi Okamura ◽  
Mika Sugiyama ◽  
Madoka Ogawa ◽  
...  

Abstract BackgroundEffective strategies to develop dementia-friendly communities (DFCs) are needed in aging societies. We aimed to propose a strategy to develop DFCs from a Japanese perspective and to evaluate an intervention program that adopted the strategy.MethodsThis study implemented a multi-level intervention that emphasized nurturing community social capital in a large apartment complex in the Tokyo metropolitan area in 2017. We offered an inclusive café that was open for extended hours as a place to socialize and a center for activities that included monthly public lectures. Individual consultation on daily life issues was also available for free at the café. Postal surveys were sent out to all older residents aged 70 years and older in 2016 and 2019. With a one-group pre-test and post-test design, we assessed changes in the proportion of older residents who had social interaction with friends and those who were confident about living in the community, even if they were living with dementia.ResultsTotals of 2,633 and 2,696 residents completed the pre and post-intervention surveys, respectively. The mean age of the pre-intervention respondents was 77.4 years; 45.7% lived alone and 7.7% reported living with impaired cognitive function. The proportion of men who had regular social interaction and were confident about living in their community with dementia increased significantly from 38.8–44.5% (p=0.008) and from 34.1–38.3% (p=0.045), respectively. Similar significant increases were observed in the subgroup of men living with impaired cognitive function, but not in the same subgroup for women.ConclusionsThe intervention benefitted male residents who were less likely to be involved in the community’s web of social networks at baseline. A strategy to create DFCs that emphasizes nurturing community social capital can form a foundation for DFCs.Trial registrationThis study was retrospectively registered in the University hospital Medical Information Network (UMIN) Clinical Trial Registry (registry number: UMIN000038193, date of registration: Oct 3, 2019).


2017 ◽  
Vol 1 (6) ◽  
Author(s):  
Fransiska YD Mardiyanto ◽  
Dedeh S Jahja ◽  
Yenni Limyati

Each year in the world, especially in Indonesia, many elderly people exposed to higher risk of dementia due to an increased number of the elderly population and the incidence of mild cognitive impairment in the elderly. The aim of this study is to find out what factors are related with cognitive function in the elderly population. The study used analytic method with cross sectional study design. Subjects were 60 elderly people; male or female ≥ 60 years old. Data were analysed with Chi Square Test (α = 0.05). Cognitive function was measured by MMSE test. The result were found a significant relation between age and cognitive function ( p = 0.014), level of education and cognitive function (p value = 0.000), physical activity and cognitive function (p value = 0.003), cognitive activity and cognitive function (p value = 0.002), and social interaction and cognitive function (p value = 0.000). Gender variable did not have relation with cognitive function (p value = 0.343). This study conclude that there was a relation between age, education level, physical activity, cognitive activity and social interaction with cognitive function in the elderly population. There was no relation between gender and cognitive function in the elderly population.Keywords: cognitive function, cognitive impairment, elderly, MMSE


2019 ◽  
Vol 8 (2) ◽  
pp. 105-123 ◽  
Author(s):  
Ya.K. Smirnova ◽  
A. Makashova ◽  
M. Kharitonova

The article deals with the problem of the ability to use ideas about other’s knowledge and the ways of changing it, the ability to de-center thinking in the process of communication in the example of understanding deception in typically developing preschoolers and preschoolers with mental retardation. The recognition of deception is considered as a cognitive function, taking into account the specific techniques of the implementation of the mental model. Empirical sample of research: 72 children of pre-school age from 5 to 6 years. Contrast samples show the specificity of the lack of social interaction tools based on the mental model. Analyzed that in a game with deceit, a child is required to use signs to anticipate events that made it known about the nascent action of another person. In children with mental retardation in a game with deceptive action, shown a situational mode of action without taking into account the model of a mental interaction partner due to the lack of ability to decentration. The data reflects the relationship between the cognitive level of development and the level of the mental model in the process of forming the basis of social cognition and social experience in the early stages of ontogenesis.


2017 ◽  
Vol 2 (2) ◽  
pp. 1
Author(s):  
Dewi Sukma Nurul Aziz ◽  
Diah Krinatuti

<p>The final stage of life in the elderly experienced changes of physical, psychological, or social that can effect instability of self concept. The aim of this research was to analyzed the effect of cognitive function, social interaction to self concept of elderly widows and widowers. The location of this research in Timbulharjo village, Sewon sub-district, Bantul district, Yogyakarta who chosen purposively with the consideration of the region which have the most elderly. The sample of this research was the elderly people aged more than 60 years old that have been abandoned by partner of life during grater than or equal to 2 years a go. Sample total of this research were 30 elderly widows and 30 elderly widowers. This research showed that there were not difference of cognitive function and social interaction between of elderly widows and elderly widowers, however there was difference of self concept between of elderly widows and widowers. In addition, ages and education have correlation with cognitive function, and social interaction have correlation with self concept. Meanwhile, marital status have negative influence and social interaction have positive influence to self concept so that widows status can decrease self concept of elderly, and better social interaction than better of self concept of elderly.</p>


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