Moderate intensity intermittent exercise upregulates neurotrophic and neuroprotective genes expression and inhibits Purkinje cell loss in the cerebellum of ovariectomized rats

2020 ◽  
Vol 382 ◽  
pp. 112481
Author(s):  
Saidah Rauf ◽  
Marsetyawan HNE Soesatyo ◽  
Denny Agustiningsih ◽  
Ginus Partadiredja
Keyword(s):  
Purkinje Cell ◽  
Intermittent Exercise ◽  
Cell Loss ◽  
Ovariectomized Rats ◽  
Moderate Intensity ◽  
Genes Expression ◽  
Purkinje Cell Loss

scholarly journals Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Nartnutda Morakotsriwan ◽  
Jintanaporn Wattanathorn ◽  
Woranan Kirisattayakul ◽  
Kowit Chaisiwamongkol
Keyword(s):  
Oxidative Stress ◽  
Valproic Acid ◽  
Purkinje Cell ◽  
Rat Model ◽  
Cell Loss ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Silkworm Pupae ◽  
Oxidative Stress Status ◽  
Purkinje Cell Loss

Due to the crucial role of oxidative stress on the pathophysiology of autism and the concept of synergistic effect, the benefit of the combined extract of purple rice and silkworm pupae (AP1) for autism disorder was the focus. Therefore, we aimed to determine the effect of AP1 on autistic-like behaviors, oxidative stress status, and histopathological change of cerebellum in valproic acid (VPA) rat model of autism. VPA was injected on postnatal day (PND) 14 and the animals were orally given AP1 at doses of 50, 100, and 200 mg·kg−1BW between PND 14 and PND 40. The autism-like behaviors were analyzed via hot-plate, rotarod, elevated plus-maze, learning, memory, and social behavior tests. Oxidative stress and the histological change in the cerebellum were assessed at the end of study. AP1 treated rats improved behaviors in all tests except that in hot-plate test. The improvement of oxidative stress and Purkinje cell loss was also observed in the cerebellum of VPA-treated rats. Our data suggest that AP1 partially reduced autism-like behaviors by improving oxidative stress and Purkinje cell loss. Further research is required to identify the active ingredients in AP1 and gender difference effect.

Reply: Purkinje cell loss in essential tremor

2014 ◽  
Vol 29 (10) ◽  
pp. 1330-1331 ◽  
Author(s):  
Holly A. Shill ◽  
Charles H. Adler ◽  
Joseph G. Hentz
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Cell Loss ◽  
Purkinje Cell Loss

Does Seizure Activity Produce Purkinje Cell Loss?

Epilepsia ◽  
1984 ◽  
Vol 25 (6) ◽  
pp. 747-751 ◽  
Author(s):  
Mogens Dam ◽  
Tom Bolwig ◽  
Marianne Hertz ◽  
Joseph Bajorec ◽  
Peter Lomax ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Seizure Activity ◽  
Cell Loss ◽  
Purkinje Cell Loss

Cerebellar Purkinje cell loss in aging Hu-Bcl-2 transgenic mice

2004 ◽  
Vol 475 (4) ◽  
pp. 481-492 ◽  
Author(s):  
Hadi Zanjani ◽  
Y. Lemaigre-Dubreuil ◽  
Niranjala J.K. Tillakaratne ◽  
Andrei Blokhin ◽  
Robert P. McMahon ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Purkinje Cell ◽  
Cell Loss ◽  
Cerebellar Purkinje Cell ◽  
Purkinje Cell Loss

scholarly journals Purkinje cell loss causes cerebellar hypoplasia and motor impairment in EBP1 deficient mice

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S104
Author(s):  
Inwoo Hwang ◽  
Hyeonjeong Park ◽  
Seongbong Jo ◽  
Jee-Yin Ahn
Keyword(s):  
Purkinje Cell ◽  
Motor Impairment ◽  
Cell Loss ◽  
Cerebellar Hypoplasia ◽  
Purkinje Cell Loss ◽  
Deficient Mice

scholarly journals Purkinje cell loss in essential tremor

2014 ◽  
Vol 29 (10) ◽  
pp. 1329-1330 ◽  
Author(s):  
Elan D. Louis ◽  
Phyllis L. Faust
Keyword(s):  
Purkinje Cell ◽  
Essential Tremor ◽  
Cell Loss ◽  
Purkinje Cell Loss
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