Molecular mechanism of high altitude respiration: primary structure of a minor hemoglobin component from Tufted duck (Aythya fuligula, Anseriformes)

2004 ◽  
Vol 326 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Ghosia Lutfullah ◽  
Syed Abid Ali ◽  
Atiya Abbasi
Keyword(s):  
High Altitude ◽  
Molecular Mechanism ◽  
Primary Structure ◽  
Tufted Duck ◽  
A Minor

Crystal Structure Determination of N-(para-Chlorophenyl) Phthalimide and Analysis of its Formation from N-(para-Chlorophenyl) Phthalanilic Acid

1974 ◽  
Vol 29 (11-12) ◽  
pp. 769-779 ◽  
Author(s):  
B. L. Farmer ◽  
J. B. Lando
Keyword(s):  
Crystal Structure ◽  
Molecular Mechanism ◽  
Structure Determination ◽  
Crystalline Phase ◽  
Molecular Motion ◽  
High Energy ◽  
Cyclization Reaction ◽  
Bond Rotation ◽  
A Minor

Crystalline N-(para-chlorophenyl) phthalanilic acid undergoes a topochemical cyclization reaction with the elimination of water yielding crystalline N-(para-chlorophenyl) phthalimide. The crystal structure of the imide product has been determined and compared to the previously determined structure of the reactant. The reaction from this particular crystalline phase of N-(para-chlorophenyl) phthalanilic acid is enhanced by the presence of a high energy molecular conformer of the acid, little molecular motion necessary for reaction, and only a minor rearrangement required to pack into the imide structure after the reaction. A detailed molecular mechanism for this reaction is proposed involving some bond rotation, but little movement of the molecule as a whole.

scholarly journals Neuroendocrine-like prostate cancer cells: neuroendocrine transdifferentiation of prostate adenocarcinoma cells

2007 ◽  
Vol 14 (3) ◽  
pp. 531-547 ◽  
Author(s):  
Ta-Chun Yuan ◽  
Suresh Veeramani ◽  
Ming-Fong Lin
Keyword(s):  
Prostate Cancer ◽  
Molecular Mechanism ◽  
Biochemical Properties ◽  
Normal Prostate ◽  
Independent State ◽  
Epithelial Compartment ◽  
Neuroendocrine Transdifferentiation ◽  
A Minor

Neuroendocrine (NE) cells represent a minor cell population in the epithelial compartment of normal prostate glands and may play a role in regulating the growth and differentiation of normal prostate epithelia. In prostate tumor lesions, the population of NE-like cells, i.e., cells exhibiting NE phenotypes and expressing NE markers, is increased that correlates with tumor progression, poor prognosis, and the androgen-independent state. However, the origin of those NE-like cells in prostate cancer (PCa) lesions and the underlying molecular mechanism of enrichment remain an enigma. In this review, we focus on discussing the distinction between NE-like PCa and normal NE cells, the potential origin of NE-like PCa cells, and in vitro and in vivo studies related to the molecular mechanism of NE transdifferentiation of PCa cells. The data together suggest that PCa cells undergo a transdifferentiation process to become NE-like cells, which acquire the NE phenotype and express NE markers. Thus, we propose that those NE-like cells in PCa lesions were originated from cancerous epithelial cells, but not from normal NE cells, and should be defined as ‘NE-like PCa cells’. We further describe the biochemical properties of newly established, stable NE-like lymph node carcinoma of the prostate (LNCaP) cell lines, transdifferentiated from androgen-sensitive LNCaP cells under androgen-deprived conditions. Knowledge of understanding NE-like PCa cells will help us to explore new therapeutic strategies for treating PCa.

Primary Structure of a Minor Ribonuclease from Aspergillus saitoi1

1982 ◽  
Vol 91 (5) ◽  
pp. 1495-1509 ◽  
Author(s):  
Hideaki WATANABE ◽  
Kazuko OHGI ◽  
Masachika IRIE
Keyword(s):  
Primary Structure ◽  
A Minor

scholarly journals Primary structure of the histone H2A and H2B genes and their flanking sequences in a minor histone gene cluster of Xenopus laevis

FEBS Letters ◽  
1982 ◽  
Vol 144 (2) ◽  
pp. 235-241 ◽  
Author(s):  
A.F.M. Moorman ◽  
P.A.J. De Boer ◽  
R.T.M. De Laaf ◽  
O.H.J. Destrée
Keyword(s):  
Xenopus Laevis ◽  
Gene Cluster ◽  
Primary Structure ◽  
Histone Gene ◽  
Histone H2a ◽  
Flanking Sequences ◽  
A Minor

Primary structure of the histone H3 and H4 genes and their flanking sequences in a minor histone gene cluster of Xenopus laevis

FEBS Letters ◽  
1981 ◽  
Vol 136 (1) ◽  
pp. 45-52 ◽  
Author(s):  
A.F.M. Moorman ◽  
P.A.J. De Boer ◽  
R.T.M. De Laaf ◽  
W.M.A.M. Van Dongen ◽  
O.H.J. Destrée
Keyword(s):  
Xenopus Laevis ◽  
Gene Cluster ◽  
Primary Structure ◽  
Histone H3 ◽  
Histone Gene ◽  
Flanking Sequences ◽  
A Minor

scholarly journals The diurnal and seasonal variability of ice nucleating particles at the High Altitude Station Jungfraujoch (3580 m a.s.l.), Switzerland

2021 ◽  
Author(s):  
Cyril Brunner ◽  
Benjamin Tobias Brem ◽  
Martine Collaud Coen ◽  
Franz Conen ◽  
Martin Steinbacher ◽  
...  
Keyword(s):  
High Altitude ◽  
Diurnal Cycle ◽  
Radiative Properties ◽  
Saharan Dust ◽  
High Time Resolution ◽  
Research Station ◽  
Data Set ◽  
Diurnal Variability ◽  
Special Events ◽  
A Minor

Abstract. Cloud radiative properties, cloud lifetime, and precipitation initiation are strongly influenced by the cloud phase. Between ~ 235 and 273 K, ice nucleating particles (INPs) are responsible for the initial phase transition from the liquid to the ice phase in cloud hydrometeors. This study analyzes immersion-mode INP concentrations measured at 243 K at the High Altitude Research Station Jungfraujoch (3580 m a.s.l.) between February 2020 and January 2021, thereby presenting the longest continuous, high-resolution (20 min) data set of online INP measurements to date. The high time resolution and continuity allow to study the seasonal and the diurnal variability of INPs. After exclusion of special events, like Saharan dust events (SDEs), we found a seasonal cycle of INPs, highest in April (median in spring 3.1 INP std L−1), followed by summer (median: 1.6 INP std L−1) and lowest in fall and winter (median: 0.5 INP std L−1 and 0.7 INP std L−1, respectively). Pollen or subpollen particles were deemed unlikely to be responsible for elevated INP concentrations in spring and summer, as periods with high pollen loads from nearby measurement stations do not coincide with the periods of high INP concentrations. Furthermore, for days when the site was purely in the free troposphere (FT), no diurnal cycle in INP concentrations was observed, while days with boundary layer intrusions (BLI) showed a diurnal cycle. The seasonal and diurnal variability of INPs during periods excluding SDEs is with a factor of 7 and 3.3, respectively, significantly lower than the overall variability observed in INP concentration including SDEs of more than three orders of magnitude, when peak values result from SDEs. The median INP concentration over the analyzed 12 months was 1.2 INP std L−1 for FT periods excluding SDEs, and 1.4 INP std L−1 for both FT and BLI, and incl. SDEs, reflecting that despite SDEs showing strong but comparatively brief INP signals, they have a minor impact on the observed annual median INP concentration.

scholarly journals Observations of fluorescent aerosol–cloud interactions in the free troposphere at the High-Altitude Research Station Jungfraujoch

2016 ◽  
Vol 16 (4) ◽  
pp. 2273-2284 ◽  
Author(s):  
I. Crawford ◽  
G. Lloyd ◽  
E. Herrmann ◽  
C. R. Hoyle ◽  
K. N. Bower ◽  
...  
Keyword(s):  
High Altitude ◽  
Pseudomonas Syringae ◽  
Wide Band ◽  
Cloud Microphysics ◽  
Research Station ◽  
Air Masses ◽  
Hierarchical Agglomerative Cluster ◽  
Aerosol Fraction ◽  
Aerosol Cloud Interactions ◽  
A Minor

Abstract. The fluorescent nature of aerosol at a high-altitude Alpine site was studied using a wide-band integrated bioaerosol (WIBS-4) single particle multi-channel ultraviolet – light-induced fluorescence (UV-LIF) spectrometer. This was supported by comprehensive cloud microphysics and meteorological measurements with the aims of cataloguing concentrations of bio-fluorescent aerosols at this high-altitude site and also investigating possible influences of UV–fluorescent particle types on cloud–aerosol processes. Analysis of background free tropospheric air masses, using a total aerosol inlet, showed there to be a minor increase in the fluorescent aerosol fraction during in-cloud cases compared to out-of-cloud cases. The size dependence of the fluorescent aerosol fraction showed the larger aerosol to be more likely to be fluorescent with 80 % of 10 μm particles being fluorescent. Whilst the fluorescent particles were in the minority (NFl∕NAll  =  0.27 ± 0.19), a new hierarchical agglomerative cluster analysis approach, Crawford et al. (2015) revealed the majority of the fluorescent aerosols were likely to be representative of fluorescent mineral dust. A minor episodic contribution from a cluster likely to be representative of primary biological aerosol particles (PBAP) was also observed with a wintertime baseline concentration of 0.1 ± 0.4 L−1. Given the low concentration of this cluster and the typically low ice-active fraction of studied PBAP (e.g. pseudomonas syringae), we suggest that the contribution to the observed ice crystal concentration at this location is not significant during the wintertime.

scholarly journals Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Neena Amatya Gorkhali ◽  
Kunzhe Dong ◽  
Min Yang ◽  
Shen Song ◽  
Adiljian Kader ◽  
...  
Keyword(s):  
High Altitude ◽  
Molecular Mechanism ◽  
Genomic Analysis ◽  
High Altitude Adaptation ◽  
Altitude Adaptation
Sign in / Sign up

Export Citation Format

Share Document