Neuroprotective effects of ginseng saponins against L-type Ca2+ channel-mediated cell death in rat cortical neurons

2008 ◽  
Vol 365 (3) ◽  
pp. 399-405 ◽  
Author(s):  
Sunoh Kim ◽  
Seung-Yeol Nah ◽  
Hyewhon Rhim
Keyword(s):  
Cell Death ◽  
Cortical Neurons ◽  
Neuroprotective Effects ◽  
Rat Cortical Neurons

Mechanisms of ammonia-induced cell death in rat cortical neurons: Roles of NMDA receptors and glutathione

2005 ◽  
Vol 47 (1-2) ◽  
pp. 51-57 ◽  
Author(s):  
A KLEJMAN ◽  
M WEGRZYNOWICZ ◽  
E SZATMARI ◽  
B MIODUSZEWSKA ◽  
M HETMAN ◽  
...  
Keyword(s):  
Cell Death ◽  
Nmda Receptors ◽  
Cortical Neurons ◽  
Rat Cortical Neurons

scholarly journals PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons

Channels ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 53-58 ◽  
Author(s):  
James Osei-Owusu ◽  
Junhua Yang ◽  
Maria Del Carmen Vitery ◽  
Mengnan Tian ◽  
Zhaozhu Qiu
Keyword(s):  
Cell Death ◽  
Chloride Channel ◽  
Cortical Neurons ◽  
Rat Cortical Neurons

scholarly journals Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Masahiro Fuwa ◽  
Masaaki Kageyama ◽  
Koji Ohashi ◽  
Masaaki Sasaoka ◽  
Ryuichi Sato ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Nr2b Subunit ◽  
Neuroprotective Effects ◽  
Receptor Antagonism ◽  
Rat Brain Membranes ◽  
Rat Cortical Neurons ◽  
Orally Active ◽  
Related Compounds

AbstractIn addition to its role in the treatment of pancreatitis, the serine protease inhibitor nafamostat exhibits a retinal protective effect. However, the exact mechanisms underlying this effect are unknown. In this study, the neuroprotective effects of nafamostat and its orally active derivative sepimostat against excitotoxicity were further characterised in vitro and in vivo. In primary rat cortical neurons, nafamostat completely suppressed N-methyl-D-aspartate (NMDA)-induced cell death. Intravitreal injection of nafamostat and sepimostat protected the rat retina against NMDA-induced degeneration, whereas the structurally related compounds, gabexate and camostat, did not. The neuroprotective effects of nafamostat and the NR2B antagonist ifenprodil were remarkably suppressed by spermidine, a naturally occurring polyamine that modulates the NR2B subunit. Both nafamostat and sepimostat inhibited [3H]ifenprodil binding to fractionated rat brain membranes. Thus, nafamostat and sepimostat may exert neuroprotective effects against excitotoxic retinal degeneration through NMDA receptor antagonism at the ifenprodil-binding site of the NR2B subunit.

Neuroprotective effects of emodin in rat cortical neurons against β-amyloid-induced neurotoxicity

2010 ◽  
Vol 1347 ◽  
pp. 149-160 ◽  
Author(s):  
Tao Liu ◽  
Hui Jin ◽  
Qin-Ru Sun ◽  
Jie-Hua Xu ◽  
Hai-Tao Hu
Keyword(s):  
Cortical Neurons ◽  
Neuroprotective Effects ◽  
Rat Cortical Neurons ◽  
Β Amyloid

α-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

2001 ◽  
Vol 312 (3) ◽  
pp. 125-128 ◽  
Author(s):  
Lei Zhang ◽  
Gou qaing Xing ◽  
Jeffery L. Barker ◽  
Yoong Chang ◽  
Dragan Maric ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Lipoic Acid ◽  
Cortical Neurons ◽  
Signalling Pathway ◽  
Rat Cortical Neurons

scholarly journals Glutamate Excitotoxicity Is Involved in Cell Death Caused by Tributyltin in Cultured Rat Cortical Neurons

2005 ◽  
Vol 89 (1) ◽  
pp. 235-242 ◽  
Author(s):  
Yusuke Nakatsu ◽  
Yaichiro Kotake ◽  
Kazuya Komasaka ◽  
Hiroko Hakozaki ◽  
Ryota Taguchi ◽  
...  
Keyword(s):  
Cell Death ◽  
Cortical Neurons ◽  
Glutamate Excitotoxicity ◽  
Rat Cortical Neurons
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