FTY720 inhibits S1P-mediated endothelial healing: Relationship to S1P1-receptor surface expression

2008 ◽  
Vol 370 (4) ◽  
pp. 603-608 ◽  
Author(s):  
Vera Krump-Konvalinkova ◽  
Ilona Chwalla ◽  
Wolfgang Siess
Keyword(s):  
Surface Expression ◽  
S1p1 Receptor ◽  
Healing Relationship ◽  
Receptor Surface Expression

Phorbol ester–induced PKCϵ down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation

Blood ◽  
2009 ◽  
Vol 113 (13) ◽  
pp. 3080-3087 ◽  
Author(s):  
Giuliana Gobbi ◽  
Prisco Mirandola ◽  
Cecilia Carubbi ◽  
Cristina Micheloni ◽  
Chiara Malinverno ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Phorbol Ester ◽  
Phorbol Esters ◽  
Surface Expression ◽  
Low Concentrations ◽  
Differentiating Agents ◽  
Receptor Surface Expression ◽  
Induced Apoptosis ◽  
Necrosis Factor ◽  
Made In

AbstractDespite the relevant therapeutic progresses made in these last 2 decades, the prognosis of acute myeloid leukemia (AML) remains poor. Phorbol esters are used at very low concentrations as differentiating agents in the therapy of myeloid leukemias. Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL), in turn, is a death ligand that spares normal cells and is therefore currently under clinical trials for cancer therapy. Emerging evidence, however, suggests that TRAIL is also involved in nonapoptotic functions, like cell differentiation. PKCϵ is differentially modulated along normal hematopoiesis, and its levels modulate the response of hematopoietic precursors to TRAIL. Here, we investigated the effects of the combination of phorbol esters (phorbol ester 4-β-phorbol-12,13-dibutyrate [PDBu]) and TRAIL in the survival/differentiation of AML cells. We demonstrate here that PDBu sensitizes primary AML cells to both the apoptogenic and the differentiative effects of TRAIL via PKCϵ down-modulation, without affecting TRAIL receptor surface expression. We believe that the use of TRAIL in combination with phorbol esters (or possibly more specific PKCϵ down-modulators) might represent a significative improvement of our therapeutic arsenal against AML.

Analysis of Glutamate Receptor Surface Expression in Acute Hippocampal Slices

2002 ◽  
Vol 2002 (137) ◽  
pp. pl8-pl8 ◽  
Author(s):  
D. R. Grosshans ◽  
D. A. Clayton ◽  
S. J. Coultrap ◽  
M. D. Browning
Keyword(s):  
Glutamate Receptor ◽  
Hippocampal Slices ◽  
Surface Expression ◽  
Receptor Surface Expression ◽  
Acute Hippocampal Slices

scholarly journals An Interactive Network of Elastase, Secretases, and PAR-2 Protein Regulates CXCR1 Receptor Surface Expression on Neutrophils

2014 ◽  
Vol 289 (30) ◽  
pp. 20516-20525 ◽  
Author(s):  
Martina Bakele ◽  
Amelie S. Lotz-Havla ◽  
Anja Jakowetz ◽  
Melanie Carevic ◽  
Veronica Marcos ◽  
...  
Keyword(s):  
Surface Expression ◽  
Interactive Network ◽  
Receptor Surface Expression

scholarly journals Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30684 ◽  
Author(s):  
Congcong Zhang ◽  
Saskia Helmsing ◽  
Marta Zagrebelsky ◽  
Thomas Schirrmann ◽  
Andrea L. J. Marschall ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Surface Expression ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Receptor Surface Expression
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