scholarly journals Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure

2011 ◽  
Vol 408 (3) ◽  
pp. 388-392 ◽  
Author(s):  
Elizabeth L. Lockamy ◽  
Razvan L. Cornea ◽  
Christine B. Karim ◽  
David D. Thomas
Keyword(s):  
Heart Failure ◽  
Gene Therapy ◽  
Molecular Mechanism ◽  
Insight Into

Artificial RNA Editing with ADAR for Gene Therapy

2020 ◽  
Vol 20 (1) ◽  
pp. 44-54 ◽  
Author(s):  
Sonali Bhakta ◽  
Toshifumi Tsukahara
Keyword(s):  
Gene Therapy ◽  
Genetic Code ◽  
Molecular Mechanism ◽  
Rna Editing ◽  
Comparative Studies ◽  
Genetic Diseases ◽  
Adenosine Deaminases ◽  
Family Protein ◽  
Hydrolytic Deamination

Editing mutated genes is a potential way for the treatment of genetic diseases. G-to-A mutations are common in mammals and can be treated by adenosine-to-inosine (A-to-I) editing, a type of substitutional RNA editing. The molecular mechanism of A-to-I editing involves the hydrolytic deamination of adenosine to an inosine base; this reaction is mediated by RNA-specific deaminases, adenosine deaminases acting on RNA (ADARs), family protein. Here, we review recent findings regarding the application of ADARs to restoring the genetic code along with different approaches involved in the process of artificial RNA editing by ADAR. We have also addressed comparative studies of various isoforms of ADARs. Therefore, we will try to provide a detailed overview of the artificial RNA editing and the role of ADAR with a focus on the enzymatic site directed A-to-I editing.

scholarly journals Hypocalcemic cardiomyopathy after parathyroidectomy in a patient with uremia: A case report and literature review

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052094211
Author(s):  
Wei Zhang ◽  
Feng Xue ◽  
Quandong Bu ◽  
Xuemei Liu
Keyword(s):  
Heart Failure ◽  
Case Report ◽  
Secondary Hyperparathyroidism ◽  
Calcium Supplementation ◽  
Severe Heart Failure ◽  
Cardiac Complications ◽  
Refractory Heart Failure ◽  
First Case ◽  
Insight Into

Hypocalcemia is a rare, but reversible, cause of dilated cardiomyopathy. Although cardiomyopathy may cause severe heart failure, calcium supplementation can reverse heart failure. We report here a patient with uremia and secondary hyperparathyroidism, who was complicated by persistent hypocalcemia and refractory heart failure. The cardiac failure was refractory to treatment with digitalis and diuretics, but dramatically responded to calcium therapy and restoration of normocalcemia. As a result, the patient was eventually diagnosed with hypocalcemic cardiomyopathy. To the best of our knowledge, this is the first case of this disease to be reported in a patient with uremia. Findings from our case may help clinicians to better understand hypocalcemic cardiomyopathy. Our case might also provide new insight into long-term cardiac complications and prognoses of patients undergoing parathyroidectomy due to secondary hyperparathyroidism.

scholarly journals AAV Gene Therapy Prevents and Reverses Heart Failure in a Murine Knockout Model of Barth Syndrome

2020 ◽  
Vol 126 (8) ◽  
pp. 1024-1039 ◽  
Author(s):  
Suya Wang ◽  
Yifei Li ◽  
Yang Xu ◽  
Qing Ma ◽  
Zhiqiang Lin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gene Therapy ◽  
Barth Syndrome ◽  
Knockout Model

Insight into the molecular mechanism of a herbal injection by integrating network pharmacology and in vitro

2015 ◽  
Vol 173 ◽  
pp. 91-99 ◽  
Author(s):  
Yi-min Ma ◽  
Xin-zhuang Zhang ◽  
Zhen-zhen Su ◽  
Na Li ◽  
Liang Cao ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Network Pharmacology ◽  
Insight Into

Tailoring diuretic therapy in acute heart failure: insight into early diuretic response predictors

2013 ◽  
Vol 102 (10) ◽  
pp. 745-753 ◽  
Author(s):  
João Pedro Ferreira ◽  
Mário Santos ◽  
Sofia Almeida ◽  
Irene Marques ◽  
Paulo Bettencourt ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Diuretic Therapy ◽  
Response Predictors ◽  
Diuretic Response ◽  
Insight Into

scholarly journals Molecular mechanism of defective intracellular calcium release in heart failure and lethal arrhythmia

2012 ◽  
Vol 140 (6) ◽  
pp. 250-254
Author(s):  
Masafumi Yano ◽  
Takeshi Yamamoto ◽  
Shigeki Kobayashi ◽  
Masunori Matsuzaki
Keyword(s):  
Heart Failure ◽  
Intracellular Calcium ◽  
Molecular Mechanism ◽  
Calcium Release ◽  
Lethal Arrhythmia ◽  
Intracellular Calcium Release

Quantitative proteomic analysis of global effect of LLL12 on U87 cell's proteome: An insight into the molecular mechanism of LLL12

2015 ◽  
Vol 113 ◽  
pp. 127-142 ◽  
Author(s):  
Rekha Jain ◽  
Prajakta Kulkarni ◽  
Snigdha Dhali ◽  
Srikanth Rapole ◽  
Sanjeeva Srivastava
Keyword(s):  
Molecular Mechanism ◽  
Proteomic Analysis ◽  
Global Effect ◽  
Quantitative Proteomic Analysis ◽  
Insight Into
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