Autocrine motility factor secreted by HeLa cells inhibits the growth of many cancer cells by regulating AKT/ERK signaling

2020 ◽  
Vol 525 (3) ◽  
pp. 557-562 ◽  
Author(s):  
Hee Sung Park ◽  
Nam Ho Jeoung
Keyword(s):  
Cancer Cells ◽  
Hela Cells ◽  
Erk Signaling ◽  
Autocrine Motility Factor ◽  
Motility Factor

scholarly journals Hexokinase 2 Promotes Cell Growth and Tumor Formation Through the Raf/MEK/ERK Signaling Pathway in Cervical Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Nan Cui ◽  
Lu Li ◽  
Qian Feng ◽  
Hong-mei Ma ◽  
Dan Lei ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Hela Cells ◽  
Tumor Formation ◽  
Erk Signaling ◽  
Cyclin A1 ◽  
Hexokinase 2 ◽  
Cervical Cancer Cells

Hexokinase 2 (HK2) is a member of the hexokinases (HK) that has been reported to be a key regulator during glucose metabolism linked to malignant growth in many types of cancers. In this study, stimulation of HK2 expression was observed in squamous cervical cancer (SCC) tissues, and HK2 expression promoted the proliferation of cervical cancer cells in vitro and tumor formation in vivo by accelerating cell cycle progression, upregulating cyclin A1, and downregulating p27 expression. Moreover, transcriptome sequencing analysis revealed that MAPK3 (ERK1) was upregulated in HK2-overexpressing HeLa cells. Further experiments found that the protein levels of p-Raf, p-MEK1/2, ERK1/2, and p-ERK1/2 were increased in HK2 over-expressing SiHa and HeLa cells. When ERK1/2 and p-ERK1/2 expression was blocked by an inhibitor (FR180204), reduced cyclin A1 expression was observed in HK2 over-expressing cells, with induced p27 expression and inhibited cell growth. Therefore, our data demonstrated that HK2 promoted the proliferation of cervical cancer cells by upregulating cyclin A1 and down-regulating p27 expression through the Raf/MEK/ERK signaling pathway.

scholarly journals Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

2002 ◽  
Vol 86 (12) ◽  
pp. 1914-1919 ◽  
Author(s):  
H Niizeki ◽  
M Kobayashi ◽  
I Horiuchi ◽  
N Akakura ◽  
J Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
Autocrine Motility Factor ◽  
Motility Factor ◽  
Pancreatic Cancer Cells

scholarly journals Autocrine Motility Factor Promotes HER2 Cleavage and Signaling in Breast Cancer Cells

2012 ◽  
Vol 73 (4) ◽  
pp. 1411-1419 ◽  
Author(s):  
Dhong Hyo Kho ◽  
Pratima Nangia-Makker ◽  
Vitaly Balan ◽  
Victor Hogan ◽  
Larry Tait ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Autocrine Motility Factor ◽  
Motility Factor

scholarly journals Expression of Gp78/Autocrine Motility Factor Receptor and Endocytosis of Autocrine Motility Factor in Human Thyroid Cancer Cells

Cureus ◽  
2019 ◽  
Author(s):  
Sam M Wiseman ◽  
Liliana D Kojic ◽  
Katayoon Kassian ◽  
Steven J Jones ◽  
Bharat Joshi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Human Thyroid ◽  
Autocrine Motility Factor ◽  
Motility Factor ◽  
Thyroid Cancer Cells
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