scholarly journals Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells

2021 ◽  
Author(s):  
Yan Li ◽  
Panpan Wang ◽  
Zhuoling Zou ◽  
Qi Pan ◽  
Xiaoyun Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells

2021 ◽  
pp. 114081
Author(s):  
Min-Gu Lee ◽  
Yun-Suk Kwon ◽  
Kyung-Soo Nam ◽  
Seo Yeon Kim ◽  
In Hyun Hwang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Mushroom Extract

Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway

2013 ◽  
Vol 220 (3) ◽  
pp. 219-228 ◽  
Author(s):  
Hongzhong Li ◽  
Bing Yang ◽  
Jing Huang ◽  
Tingxiu Xiang ◽  
Xuedong Yin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Growth Potential

Tumor suppressive activity of miR-424-5p in breast cancer cells through targeting PD-L1 and modulating PTEN/PI3K/AKT/mTOR signaling pathway

Life Sciences ◽  
2020 ◽  
Vol 259 ◽  
pp. 118239 ◽  
Author(s):  
Narges Dastmalchi ◽  
Mohammad Ali Hosseinpourfeizi ◽  
Seyed Mahdi Banan Khojasteh ◽  
Behzad Baradaran ◽  
Reza Safaralizadeh
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Mtor Signaling ◽  
Suppressive Activity ◽  
Mtor Signaling Pathway

SIK2 Promotes Cisplatin Resistance Induced by Aerobic Glycolysis in Breast Cancer Cells through PI3K/AKT/mTOR Signaling Pathway

2020 ◽  
Author(s):  
Shoukai Zong ◽  
Wei Dai ◽  
Wencheng Fang ◽  
Xiangting Guo ◽  
Kai Wang
Keyword(s):  
Breast Cancer ◽  
Western Blot ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Breast Cancer Cells ◽  
Cisplatin Resistance ◽  
Aerobic Glycolysis ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Protein Levels

Abstract Objective This study aimed to investigate the effect of SIK2 on cisplatin resistance induced by aerobic glycolysis in breast cancer cells and its potential mechanism. Methods qRT-PCR and Western blot were used to detect SIK2 mRNA and protein levels. Cisplatin (DDP) resistant cell lines of breast cancer cells were established, CCK-8 was used to measure and evaluate the viability, and Transwell was used to evaluate the cell invasion capability. Flow cytometry was adopted to evaluate the apoptosis rate. The glycolysis level was evaluated by measuring glucose consumption and lactic acid production. The protein levels of p-PI3K, p- protein kinase B (Akt) and p-mTOR were determined by western blot. Results SIK2 is highly expressed in breast cancer tissues and cells compared with adjacent tissues and normal human breast epithelial cells, and has higher diagnostic value for breast cancer. Silencing SIK2 expression can inhibit proliferation and invasion of breast cancer cells and induce their apoptosis. In addition, SIK2 knockdown inhibits glycolysis, reverses the resistance of drug-resistant cells to cisplatin, and inhibits PI3K/AKT/mTOR signaling pathway. When LY294002 is used to inhibit PI3K/AKT/mTOR signaling pathway, the effect of Sh-SIK2 on aerobic glycolysis of breast cancer cells can be reversed. Conclusion SIK2 can promote cisplatin resistance caused by aerobic glycolysis of breast cancer cells through PI3K/AKT/mTOR signaling pathway, which may be a new target to improve cisplatin resistance of breast cancer cells.

scholarly journals Protective effect of hsa‐miR ‐570‐3p targeting CD274 on triple negative breast cancer by blocking PI3K / AKT / mTOR signaling pathway

2020 ◽  
Vol 36 (8) ◽  
pp. 581-591 ◽  
Author(s):  
Li‐Li Wang ◽  
Wei‐Wei Huang ◽  
Jing Huang ◽  
Rong‐Fang Huang ◽  
Na‐Ni Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

scholarly journals Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153155 ◽  
Author(s):  
Chakrabhavi Dhananjaya Mohan ◽  
V. Srinivasa ◽  
Shobith Rangappa ◽  
Lewis Mervin ◽  
Surender Mohan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Mtor Signaling ◽  
Human Breast Cancer Cells ◽  
Mtor Signaling Pathway ◽  
Human Breast

scholarly journals Expression of mTOR Signaling Pathway Molecules in Triple-Negative Breast Cancer

Pathobiology ◽  
2019 ◽  
Vol 86 (5-6) ◽  
pp. 315-321 ◽  
Author(s):  
Kei Ito ◽  
Hideaki Ogata ◽  
Naoko Honma ◽  
Kazutoshi Shibuya ◽  
Tetuo Mikami
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells

APOPTOSIS ◽  
2014 ◽  
Vol 19 (7) ◽  
pp. 1148-1164 ◽  
Author(s):  
Shweta Shrivastava ◽  
Prasad Kulkarni ◽  
Dinesh Thummuri ◽  
Manish Kumar Jeengar ◽  
V. G. M. Naidu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Mtor Signaling ◽  
Signaling Axis
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